Toxicological evaluation of Sargassum polycystum in mice with loperamide-induced constipation by Chittipong Tipbunjong, Tanaporn Hengpratom, Saranya Peerakietkhajorn, Jaruwan Mayakun, Nawiya Huipao, Pissared Khuituan, Piyaporn Surinlert, Chumpol Pholpramool

“…Constipation gradually increases in people after the age of 50 years leading to difficulty in stool passage. Until now, there have been no effective drugs without side effects. …”
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Presence of IgG antibodies is not a reliable marker of Toxoplasma gondii infection in feral mice by Lignereux, Louis, Tong, Wen Han, Tan, Sijie, Vyas, Ajai, O'handley, Ryan

“…We postulate that both the transmission route, horizontal or vertical, and natural selection processes could lead to this discordance which has been observed elsewhere in wild mice. …”
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Adeno-associated virus mediated rhodopsin delivery in preventing secondary cone degeneration in rhodopsin knockout mice by Dauletbekov, D

“…</p> <p>Subretinal injection of the vector into three-week pups of rhodopsin knockout mice with cones expressing green fluorescent protein showed restoration of rod-derived electroretinogram (ERG) responses, and preservation of cone- driven ERG responses three months after injection. …”

Effect of Pueraria mirifica subchronic treatments on ameliorating depression by increasing tryptophan hydroxylase immunoreactive neurons via estrogen receptors in ovariectomized mi... by Nattawut Tadsaichol, Wandee Udomuksorn, Ekkasit Kumarnsit, Uraporn Vongvatcharanon, Surapong Vongvatcharanon

“…Estrogen depletion leads to menopause-associated depression. Pueraria mirifica (PM) contains phytoestrogen that has been used for rejuvenating in aged women. …”
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Serotonin transporter function and emotional behaviour by Lima, J

“…Moreover, 5-HTTKO mice exhibited superior aversive learning via augmented BLA function. …”

Obesity-driven reprogramming of lung macrophages by Pohan, Clarice

“…Upon further investigation, we found that AMs from high-fat diet fed obese (>30wks) mice had larger lipid droplets than those from young lean (<12wks) and age-matched lean (>30wks) mice. …”
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Metronidazole causes skeletal muscle atrophy and modulates muscle chronometabolism by Manickam, Ravikumar, Oh, Hui Yun Penny, Tan, Chek Kun, Paramalingam, Eeswari, Wahli, Walter

“…Antibiotics lead to increased susceptibility to colonization by pathogenic organisms, with different effects on the host-microbiota relationship. …”
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Chromatin laser imaging reveals abnormal nuclear changes for early cancer detection by Chen, Yu-Cheng, Chen, Qiushu, Tan, Xiaotain, Chen, Grace, Bergin, Ingrid, Muhammad Nadeem Aslam, Fan, Xudong

“…By imaging the lasing emissions from chromatins, we discovered that, despite the absence of observable lesions, polyps, or tumors under stereoscope, high-fat mice exhibited significantly lower lasing thresholds than low-fat mice. …”
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Reverse translational approaches to population neuroimaging: using rodent models to interpret genetic associations with MRI by Tisca, C

“…The genetic similarity between humans and mice means we can measure and compare equivalent phenotypes across species. …”

Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation by Kalailingam, Pazhanichamy, Tan, Hui Bing, Jain, Neeraj, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Tan, Nguan Soon, Thanabalu, Thirumaran

“…N-WASPK14KO mice exhibited stunted growth, alopecia, dry and wrinkled skin. …”
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PIERCE1: a determinant of left-right asymmetry in mammals by Farley, H

“…</p> <p>The evaluation of nodal ciliary motility and nodal flow in mice homozygous for a <em>Pierce1</em>-null allele demonstrated that aberrant motility, leading to a lack of effective leftwards nodal flow, underlies the left-right patterning defects in these mice. …”

Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…Malfunction of the UPS often results in aberrant protein accumulation which can lead to protein aggregation and/or mis-localization affecting its function. …”

Inhibition of endoplasmic reticulum stress using 4-phenyl butyrate mitigates osteoporosis in a mouse model of hindlimb suspension by Al-Daghestani, Hiba Saad Subhi

“…Osteoporosis (OP) characterized by micro-architectural deterioration of bone tissue is a common skeletal disease in the elderly and may lead to fragility fractures. It may also negatively affect implant rehabilitation and prosthesis fixation in the older people. …”
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Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in mouse by Cruciani-Guglielmacci, Céline, Meneyrol, Kelly, Denom, Jessica, Kassis, Nadim, Rachdi, Latif, Makaci, Fatna, Migrenne-Li, Stéphanie, Daubigney, Fabrice, Georgiadou, Eleni, Denis, Raphaël G., Sanchez-Archidona, Ana Rodriguez, Paul, Jean-Louis, Thorens, Bernard, Rutter, Guy A., Magnan, Christophe, Le Stunff, Hervé, Janel, Nathalie

“…Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. …”
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Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head by Loo, Jing Hong, Lee, Ying Shi, Woon, Chang Yi, Yong, Victor H. K., Tan, Bingyao, Schmetterer, Leopold, Chong, Rachel S.

“…Cav-1 KO mice exhibited higher IOP and lower pSTR amplitude. …”
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Novel nitric oxide donors for the dispersal and control of Pseudomonas aeruginosa biofilms by Poh, Wee Han

“…Preliminary assessment of one lead compound, DEACP, in a mouse implant model of biofilm infection also suggested that dispersal may lead to poor prognosis, as higher bacterial counts were retrieved from spleen samples of mice in NO-treated groups as a consequence of dispersal. …”
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The contribution of traumatic brain injury to Alzheimer’s disease progression by Zainal Azman, JAB

“…<p>The collective data from human and rodent studies indicate that a single traumatic brain injury (TBI) in healthy individuals can lead to an increased plaque burden, potentially accelerating the onset of Alzheimer's Disease (AD). …”

OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy by Zeng, Yong, Gao, Shasha, Li, Yichao, Marangoni, Dario, De Silva, Tharindu, Wong, Wai T., Chew, Emily Y., Sun, Xun, Li, Tiansen, Sieving, Paul A., Qian, Haohua

“…Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. …”
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Focused array analysis of diabetic skin wound. by Ling, Wei Yin.

“…To understand the interplay among these players behind angiogenesis and discover possible therapeutic targets, a focused array approach employing real-time quantitative PCR technique was used to unravel the differential gene molecular profiles in the healing of chronic diabetic mice wounds compared to that of normal wounds. In vivo analyses using wildtype (+/+) and diabetic (ob/ob) mice wounds revealed many angiogenic factors and inflammatory mediators with altered gene expression patterns and levels leading to the chronic inflamed state of diabetic wounds. …”
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Modeling the proactive driving behavior of connected vehicles : a cell-based simulation approach by Zhu, Feng, Ukkusuri, Satish V.

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