Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases by Gayatri

RES.10-001 Making Science and Engineering Pictures, Fall 2014 by Frankel, Felice C.

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AI is a viable alternative to high throughput screening: a 318-target study by Wallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel, Eckert, Sam, de Oliveira, Saulo, Suterwala, Shabbir, PrasadPrasad, Srimukh Veccham Krishna, Shek, Stefani, Contreras, Stephanie, Hare, Stephanie, Palazzo, Teresa, O’Brien, Terrence E., Van Grack, Tessa, Williams, Tiffany, Chern, Ting-Rong, Kenyon, Victor, Lee, Andreia H., Cann, Andrew B., Bergman, Bastiaan, Anderson, Brandon M., Cox, Bryan D., Warrington, Jeffrey M., Sorenson, Jon M., Goldenberg, Joshua M., Young, Matthew A., DeHaan, Nicholas, Pemberton, Ryan P., Schroedl, Stefan, Abramyan, Tigran M., Gupta, Tushita, Mysore, Venkatesh, Presser, Adam G., Ferrando, Adolfo A., Andricopulo, Adriano D., Ghosh, Agnidipta, Ayachi, Aicha Gharbi, Mushtaq, Aisha, Shaqra, Ala M., Toh, Alan Kie Leong, Smrcka, Alan V., Ciccia, Alberto, de Oliveira, Aldo Sena, Sverzhinsky, Aleksandr, de Sousa, Alessandra Mara, Agoulnik, Alexander I., Kushnir, Alexander, Freiberg, Alexander N., Statsyuk, Alexander V., Gingras, Alexandre R., Degterev, Alexei, Tomilov, Alexey, Vrielink, Alice, Garaeva, Alisa A., Bryant-Friedrich, Amanda, Caflisch, Amedeo, Patel, Amit K., Rangarajan, Amith Vikram, Matheeussen, An, Battistoni, Andrea, Caporali, Andrea, Chini, Andrea, Ilari, Andrea, Mattevi, Andrea, Foote, Andrea Talbot, Trabocchi, Andrea, Stahl, Andreas, Herr, Andrew B., Berti, Andrew, Freywald, Andrew, Reidenbach, Andrew G., Lam, Andrew, Cuddihy, Andrew R., White, Andrew, Taglialatela, Angelo

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Cave fever by Tan, Ke Yang

“…It is a 3D animated short film that blends elements of 2D animation techniques, telling a comedic story of a dragon and a goblin.…”
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Formulation, optimization and characterization of palm kernel oil esters nanoemulsion system containing sodium diclofenac by Rezaee, Malahat

“…Opt.F and F-2 had the higher percentage of drug release. Five different terpenes based on the different chemical structure in five different concentrations were chosen as enhancer in Opt.F. …”
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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…Azithromycin-resistance mutations in acrB were rare, appearing only in Dhaka (five [1%] of 452). Phylogenetic analyses showed that most cases derived from pre-existing, locally established pathogen variants; 702 (98%) of 713 drug-resistant infections resulted from local circulation of AMR variants, not imported variants or recent de novo emergence; and pathogen variants circulated across age groups. 479 (66%) of 731 cases clustered with others that were indistinguishable by point mutations; individual clusters included multiple age groups and persisted for up to 2·3 years, and AMR determinants were invariant within clusters.…”

Ellipsometry studies on anodic aluminium oxide (AAO)growth mechanism on high purity aluminium plate by Lim, Leng Khoon

“…In the biomedical field, AAO was used many applications such as pathogens microfiltration, biomolecules quantification, drug delivery etc, However, it had been a challenge to produce the necessary microstructure for all the mentioned applications. …”
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Six Crimson Cranes / by Lim, Elizabeth, author 655947, Penguin Random House (Online service) 655978

“…And she must embrace the magic she's been taught all her life to forswear--no matter what the cost. …”
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Sustained delivery of timolol maleate from liposomal nanocarriers by Ong, Leonard Chin Hui

“…Liposomes were prepared using thin film hydration and average particle size in the range of around 100 nm was prepared using a bench top extruder and drug was actively loaded by ammonium sulphate gradient loading technique. …”
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Identification and antimicrobial susceptibility of enterococcal species isolated from cats exposed to different antibiotics by Mohd Amin, Nor Azimah

“…None of the isolates were resistant to all six antibiotics tested. Enterococcus sp. isolate was resistant to five antibiotics (amoxicillin, amoxicillin and clavulanic acid, enrofloxacin, marbofloxacin, and doxycycline). …”
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Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats by Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam

“…The pharmacokinetic behaviour of tylosin was compared in five Desert sheep and five Nubian goats. The animals were given a single dose of 20% tylosin (15 mg/kg), either intravenously (i.v.) or intramuscularly (i.m.). …”
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Antimicrobial photodynamic therapy for the remote eradication of bacteria by Yan, Evelias, Kwek, Germain, Ng, Shuang Qing, Lingesh, Shonya, Xing, Bengang

“…Thus, it can target a broad spectrum of microorganisms, owing to the indirect interaction between PSs and the bacteria, resulting in the less likelihood for the development of drug resistant bacteria strains. This review will focus on the recent progress of APDT in the last five years and some future perspectives of APDT. …”
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Factors affecting trans-scleral transport of poly (butadiene-b-ethylene oxide) polymersomes by Anita, Vincent

“…In this light, this research work examines the suitability of polymersomes for ocular drug delivery via periocular route of drug administration. …”
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A biodegradable ocular implant for long-term suppression of intraocular pressure by Ng, Xu Wen, Liu, Kerh Lin, Veluchamy, Amutha Barathi, Lwin, Nyein Chan, Wong, Tina T., Venkatraman, Subbu Subramanian

“…However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage, and lack of patient compliance. Suboptimal control of the IOP leads to disease progression and eventually to blindness. …”
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15.269 Literature, Ethics and Authority, Fall 2005 by Hafrey, Leigh

“…Readings include work by Robert Bolt, Jane Smiley, Virginia Woolf, Ursula LeGuin, Wole Soyinka, and others; films include "Three Kings," "Crouching Tiger, Hidden Dragon," "Hotel Rwanda," and others. …”
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…In drug combination experiments targeting co-mutated pathways, I show that some degree of tolerance to GM-TKI is explained by oncogenic co-mutations, but not across all lines. …”
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Enhancing breast cancer treatment: investigating the influence of polymer ratios on Luteolin-loaded TPGS/poloxamer micelles by Mod Razif, Muhammad Redza Fahmi, Liew, Kai Bin, Chan, Siok Yee, Chew, Yik Ling, Hassan, Masriana, Ahmad Hisham, Shairyzah, Abdul Rahman, Shamima, Kee, Phei Er

“…The results revealed that the optimized micelle composed of 1:5 drug: polymer ratio and a TPGS: Pol ratio of 3:1, exhibited a particle size below 40 nm, along with EE of 90%. …”
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Peptide asparaginyl ligases—renegade peptide bond makers by Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu

“…Here we review the advances in ligases, with a focus on butelase-1, and their applications in engineering bioactive peptides and precision protein modifications, antibody-drug conjugates, and live-cell labeling.…”
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Graphene oxide nanoplatelets potentiate anticancer effect of cisplatin in human lung cancer cells by Nur Farhanah Rosli, Fojtů, Michaela, Fisher, Adrian C., Pumera, Martin

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Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device by Shuddhodana, Wong, Kathy Pooi Wen, Judeh, Zaher

“…It has potential to enable clinical translation of drug-loaded cochleates with predicable drug release, absorption and bioavailability.…”
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