Changes in microbial and physicochemical properties during free-cell and encapsulated probiotic fermentation of red dragon fruit juice by Ong, Yien Yien

“…Fermentation of red dragon fruit juice with free cell and microencapsulated probiotic showed no adverse effect on the physico-chemical characteristics especially the antioxidant properties of,red dragon fruit juice. …”
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Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

“…The present work evaluated the membrane permeability of amorphous drug-polyelectrolyte/drug-protein nanoplexes across Caco-2 cell monolayer in comparison to the native drugs. …”
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Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. MTT assay was performed to test for the growth inhibitory effect of individual drugs and their combinations. …”
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Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…Red dragon fruit (RDF, Hylocereus polyrhizus) is high in betacyanins content but is understudied for its antioxidant mechanisms in liver cells. …”
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Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Understanding the dynamics of membrane protein–ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to the effects of protein modifications. …”

Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity by Chua, Huey Eng, Zhang, Fan, Zheng, Jie, Mishra, Shital Kumar, Bhowmick, Sourav Saha

“…Here we propose a hybrid modelling approach based on ordinary differential equation (ODE) and machine learning to map network rewiring in the apoptotic pathways that may be responsible for the increase of drug sensitivity of tumour cells in triple-negative breast cancer. …”
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Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

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Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells by Head, Sarah A., Shi, Wei, Zhao, Liang, Gorshkov, Kirill, Pasunooti, Kalyan, Chen, Yue, Deng, Zhiyou, Li, Ruo-jing, Shim, Joong Sup, Tan, Wenzhi, Hartung, Thomas, Zhang, Jin, Zhao, Yingming, Colombini, Marco, Liu, Jun O.

“…Itraconazole, a clinically used antifungal drug, was found to possess potent antiangiogenic and anticancer activity that is unique among the azole antifungals. …”
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Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…Furthermore, coupled with genomic and transcriptomic analyses, WTC-based testing can also help to stratify specific patient groups for assignment into appropriate clinical trials, as well as validate potential biomarkers during drug development.…”
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Transdermal Drug Delivery by Ong, Yuhui

“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Exploring the roles of mitochondrial-associated microRNAs of head and neck cancer stem cells in drug resistance and tumor recurrence by Zhu, Xiaoning, Subha, Sethu Thakachy, Fong, Voon Hoong, Tan, Wee Lin, Cheah, Yoke Kqueen

“…The primary clinical issues in HNC are drug resistance and tumor recurrence attributed to the presence of cancer stem cells (CSCs). …”
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Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles by Kwan, JJ, Coussios, CC

“…We then explore the different means by which ultrasound enables drug release, drug transport, and sonoporation of cell membranes from ultrasound-responsive nanoparticles.…”

Microneedles for diagnosis and therapeutic drug monitoring by Thean, Jia Hui

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Liposomal encapsulation of pro-NO donor drug by Koh, Cheryl Jie Yan

“…Liposomes are utilised as drug carrier due to its biocompatibility and inert nature in the physiological body, to protect the drug as well as prevent premature elimination by the body. …”
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Millifluidic synthesis of amorphous drug-polysaccharide nanoparticle complex with tunable size intended for supersaturating drug delivery applications by Tran, The-Thien, Nguyen, Minh-Hiep, Tan, Yong Zen, Chew, Jia Wei, Khan, Saif A., Hadinoto, Kunn

“…Most importantly, the ability to produce significantly smaller nanoplex (sixfold smaller) via millifluidics led to the generation of higher (≈8.5× of CUR saturation solubility) and prolonged (≈8 h) supersaturation level. These results bode well for the bioavailability enhancement potential of the drug nanoplex.…”
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The effect of rare-earth nanoparticles on drug delivery by Li, Linda Shi Wen

“…We evaluated the results of live/dead assay and confirmed the killing capacity of the drug-loaded nanoparticle. Our cell cycle analysis also showed that the drug-loaded nanoparticles reduced cell replication by arresting the cells in the G1 phase.…”
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Evaluation of drug reproductive toxicity and the underlying mechanisms by Wu, Sixian, Shang, Lijun, Xu, Wenming

“…It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity.…”

Evaluation of drug reproductive toxicity and the underlying mechanisms by Wu, Sixian, Shang, Lijun, Xu, Wenming

“…It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity.…”
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Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

“…In this review, we are discussing current knowledge about the two mycobacterial aerobic respiratory branches, their potential as drug targets, as well as potential drawbacks.…”
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