An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…MetS was defined as having three or more of the following five abnormalities: hypertriglyceridemia, HDL hypocholesterolemia, hypertension, obesity, and diabetes. …”
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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles by Nguyen, Thuy-Khanh, Selvanayagam, Ramona, Ho, Kitty K. K., Chen, Renxun, Kutty, Samuel K., Rice, Scott A., Kumar, Naresh, Barraud, Nicolas, Duong, Hien T. T., Boyer, Cyrille

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Synthesis, antimalarial activity, and molecular dynamic approaches of salophen metal complexes by Ali, Amatul Hamizah, Mukhtar, Nur Hafizah, Ling, Ng Yee, Norazmi, Nur Aqilah Zahirah, Agustar, Hani Kartini, Ling, Lau Yee, Abd Karim, Nurul Huda, Yusoff, Siti Fairus Mohd, Borzehandani, Mostafa Yousefzadeh, Hassan, Nurul Izzaty

“…Malaria is still one of the main infectious diseases in tropical climates. Various antimalarial drugs have been introduced before, such as chloroquine, primaquine, and artemisinin. …”
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Data-Driven Classification of Pharmaceutical and Biotechnology Companies by Xu, Angelina

“…We use fundamental financial data, 10-K filings, and company drug development data to develop this new classification scheme. …”
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In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus by Nagarajan, Nagasundaram, Yapp, Edward Kien Yee, Le, Nguyen Quoc Khanh, Yeh, Hui-Yuan

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Cytotoxicity and mechanisms of action of Zerumbone-loaded nanostructured lipid carrier in triple negative breast cancer cells, MDA-MB-231 by Hosseinpour, Mahnaz

“…According to the Malaysian National Cancer Registry (2006), breast cancer is one of the five most common cancers amongst Malaysian women. …”
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Loopholes. by Li, Yvonne Meini., Law, Georgina Wan Yi., Phua, Geraldine Soo Yee.

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Construction of novel optical imaging probes and their applications in bioassays by Shao, Qing

“…Chapter 3 describes the construction of a luminescent Ru(II) probe for intracellular imaging and lethal photosensitization of drug resistant bacteria. By combining enzyme recognizing specificity and photosensitizing function, this probe displays promising imaging and photokilling capabilities to the drug resistant strains, including pathogenic species like clinically isolated methicillin-resistant Staphylococcus aureus. …”
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Polycaprolactone/Cellulose acetate loaded psidium guajava essential oil electrospun nanofibrous mat dressing for healing wounds by Nor Naimah, Hussin @ Hassan, Noor Suhana, Adzahar, Lee, Thong Chuan, Izan Izwan, Misnon, Venugopal, Jayarama Reddy

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Enhancing breast cancer treatment: investigating the influence of polymer ratios on Luteolin-loaded TPGS/poloxamer micelles by Mod Razif, Muhammad Redza Fahmi, Liew, Kai Bin, Chan, Siok Yee, Chew, Yik Ling, Hassan, Masriana, Ahmad Hisham, Shairyzah, Abdul Rahman, Shamima, Kee, Phei Er

“…The results revealed that the optimized micelle composed of 1:5 drug: polymer ratio and a TPGS: Pol ratio of 3:1, exhibited a particle size below 40 nm, along with EE of 90%. …”
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Biochemical characterisation of NS2B-NS3 protease from flaviviruses by Nah, Jojo Qian Hui

“…These findings demonstrate the importance of protease activity that could be used for drug discovery process in designing inhibitor.…”
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Survey of healthcare-associated sink infrastructure, and sink trap antibiotic residues and biochemistry, in 29 UK hospitals by Rodger, G, Chau, K, Aranega Bou, P, Moore, G, Roohi, A, The SinkBug Consortium, Walker, AS, Stoesser, N

“…Antibiotics were detected in 95/287 (33%) sink traps and were associated with medicines/drug preparation rooms (p<0.001). Sink trap chemicals detected included metals, chlorine, and fluoride. …”

Blood brain barrier: a tissue engineered microfluidic chip by Musafargani, Sikkandhar, Mishra, Sachin, Gulyás, Miklós, Mahalakshmi, P., Archunan, Govindaraju, Padmanabhan, Parasuraman, Gulyás, Balázs

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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…Background: Myelofibrosis (MF) is a clonal haematopoietic disease, with median overall survival for patients with primary MF only 6.5 years. The most frequent gene mutation found in patients is JAK2V617F, causing constitutive activation of the kinase and activation of downstream signalling. …”

A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

“…The isolated rod-shaped cells were electrically quiescent unless stimulated to fire action potentials with an amplitude of 100 mV from a resting potential of approximately -70 mV. …”

Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…<p>Precise spatio-temporal control of 3’,5’-cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) is essential for normal cardiac function. …”

Single cell hydrodynamic stretching and microsieve filtration reveal genetic, phenotypic and treatment-related links to cellular deformability by Li, Fenfang, Cima, Igor, Vo, Jess Honganh, Tan, Min-Han, Ohl, Claus-Dieter

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Ion doping behavior of stöber silica-nanosynthesis and application by Song, Xiaohui

“…Besides, we can dope positive charged organic molecules inside silica nanoparticle, such as dyes, drugs, and so on. The above synthesis control is important to silica application in biosensors, drug delivery, catalysts, and battery. …”
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Studies of insulin transport across intestinal epithelium using nano-encapsulation for oral delivery by Zhang, Yiming

“…The discovery of insulin in the early 1920s brought promising hopes to pharmaceutical industries as increasing number of them have been attempting to load the drug in a capsule for the conventional oral route. …”
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