Gold-catalyzed cyclization of yndiamides with isoxazoles via α-imino gold Fischer carbenes by Tong, Z, Smith, PJ, Pickford, HD, Christensen, KE, Anderson, EA

“…By using benzisoxazoles as substrates, the reaction outcome could be switched to a formal [5+2] cyclization, leading to 1,4-oxazepines.…”

Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…While there are few clinically approved anti-IAV drugs for therapeutic and prophylactic use, these drugs have also been challenged by the emergence of drug resistance, toxicity, adverse effects and low efficacy. …”
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In silico investigations and potential approaches of Tectona grandis via targeting MMP-9 for triple negative breast cancer by Permana, Sofy, Hanum, Halida A., Azizah, Maghfira R., Ilmiyah, Silvi Z., Permana, Aiko Z., Norahmawati, Eviana, Widodo, Edwin, Fakurazi, Sharida, Kawamoto, Yoshiyuki, Endharti, Agustina T.

“…The objective of this research is to evaluate the potential of the bioactive substances of T. grandis as cancer drugs. The matrix metalloproteinase-9 structure was obtained from Protein Data Bank, while the substances derived from T. grandis were sourced from various existing studies and screened using PASS database, Lipinski’s rule of five, and Veber rule. …”
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Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…When evaluated for its effectiveness in this highly aggressive model, two doses could significantly enhance survival compared to even five times (5x) the amount of free cytokine. Remarkably, while the model was non-responsive to checkpoint inhibitor (CPI) therapy with anti-PD1 and anti-CTLA4, when combined with LbL-IL-12-NPs, we achieved complete responses with robust immune memory induction. …”
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Identification and validation of immune correlates of protection against malaria infection by Lee, Qian Qi

“…Immunisation with live sporozoites under mefloquine or chloroquine drug cover can induce protection in human volunteers who were challenged with sporozoites experimentally. …”
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Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the pre... by Tran-To Su, Chinh, Ouyang, Xuchang, Zheng, Jie, Kwoh, Chee Keong

“…Furthermore, the protocol could be useful for further drug-binding analysis and prediction of future viral mutations to which the virus evolves through adaptation and acquires resistance to the current available drugs.…”
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Development of red/near-infrared fluorescent molecules and macromolecules for biomedical applications by Yang, Cangjie

“…The hydrophobic layer of side chain was used to physically entrap drugs for chemotherapy. To address the potential problem of drug leakage, we utilized amphiphilic random copolymers containing drug-modified units as side chain of conjugated polymers instead in Chapter 7. …”
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Conservation of red blood cell signalling in Plasmodium merozoite invasion by Yong, James Jia Ming

“…Therefore, small molecule compounds that specifically target the RH5-Basigin binding opens up an attractive avenue for drug development against malaria.…”
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Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes by Dean, S, Gould, MK, Dewar, CE, Schnaufer, AC

Adaptive average arterial pressure control by multi-agent on-policy reinforcement learning by Hong, X, Ayadi, W, Alattas, KA, Mohammadzadeh, A, Salimi, M, Zhang, C

The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research by Sanfelice, D, Antolin, A, Crisp, A, Chen, Y, Bellenie, B, Brennan, P, Edwards, A, Müller, S, Al-Lazikani, B, Workman, P

Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…Whereas, for the in vivo model, leukaemia was induced in male BALB/c mice using mouse leukaemic cell line (WEHI-3) and treatment was carried out using different concentrations of BVFCE and chemotherapy drug, separately for comparison. After the treatment period (5 weeks), the mice were fasted overnight and sacrificed for biochemical, haematological and histological analyses of their liver, kidney, heart and spleen. …”
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Characterization of the translational regulation of BIM 3’ UTR by Ho, Jessie Jia Xin

“…Therefore, we are interested in the search for miRNA targets in BIM Exon 5 (E5) 3’ UTR. Previously, 100-nucleotide serial deletions of BIM E5 3’ UTR revealed regulatory clusters. …”
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Diversity-oriented synthesis encoded by deoxyoligonucleotides

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Effect of antimicrobial agents on biofilm cells and invitro development of resistance in planktonic cells of pseudomonas aeruginosa PA01 by Balasankar Meera Priyadarshini

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Targeted therapy to gastric cancer by Hou, Qian.

“…The 8 small molecule compounds were shown to be effective in inhibiting gastric cancer cell growth at nanomolar concentrations in vitro. These drugs’ targets: HSP90, proteasome, protein phosphatase and V-ATPase provide insights for drug design trend for gastric cancer therapy. …”
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Effects of hemodynamic shear stress on circulating tumor cells by How, Yunhan

“…They also exhibit elongated cell morphology, greater drug resistance and higher expression of MnSOD, as compared to normal 231-C3.…”
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Nuclear magnetic resonance spectroscopic studies of the structure and interactions between hepatitis B virus core and surface antigens with peptides by Muhamad, Azira

“…There are several approaches in designing an antiviral drug based on the virus life cycle. This study focuses on two antiviral approaches. …”
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Magnetic Droplet Merging by Hybrid Magnetic Fields by Ray, Ayan, Varma, Vijaykumar B., Wang, Zhaomeng, Wang, Zhiping, Jayaneel, P.J., Sudharsan, Natteri M., Ramanujan, Raju V.

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Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology by Shinozuka, K, Jerotic, K, Mediano, P, Zhao, AT, Preller, KH, Carhart-Harris, R, Kringelbach, ML

“…Pharmacologically, LSD induces significantly more inositol phosphate formation at the 5-HT2A receptor than DMT and psilocin, yet there are no significant between-drug differences in the selectivity of psychedelics for the 5-HT2A, 5-HT2C, or D2 receptors, relative to the 5-HT1A receptor. …”