Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel by Hairul, Nuriana Munirah, Anuar, Nor Khaizan, Zulfakar, Mohd Hanif, Salim, Norazlinaliza, Ibrahim, Salizatul Ilyana

“…Two formulations named NEG-F14 0.5% and NEG-F17 0.5% were selected for further study on the drug content, EE% and in-vitro drug release. …”
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Investigating the toxicity of ATA nanoparticles in vitro and cardioprotective effects of ATA on DOX-induced cardiotoxicity in zebrafish by Lee, Eden Hui Ling

“…A novel compound acetyltanshinone (ATA) has been discovered to have a prominent growth inhibition effect on breast cancer cells and may be potentially used as a chemotherapeutic drug. However, its property of low aqueous solubility and bioavailability poses a limitation on its drug efficacy. …”
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Developing a hollow fiber infection model system to determine the PK/PD of conjugated oligoelectrolytes against clinically relevant pathogens by Wang, Ruolan

“…Therefore, there is a pressing need for the development of novel drugs. One of the key stages in the drug discovery pipeline is understanding the pharmacokinetic/pharmacodynamic (PK/PD) of the new drug. …”
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Surface modified polymers for controlled macroscopic functions by Chng, S

“…A library of polymers with variation in end group, and with expansion of substrate scope, was characterised in detail for chemical and macroscopic properties. In particular, drug delivery properties were investigated using hole-plate bioassays and HPLC-MS methods, and it was found that the antibiotic, Penicillin V, was still active after being loaded onto the polymer scaffolds, with surface modified polymers binding and releasing more drug than the corresponding controls. …”

Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…When evaluated for its effectiveness in this highly aggressive model, two doses could significantly enhance survival compared to even five times (5x) the amount of free cytokine. Remarkably, while the model was non-responsive to checkpoint inhibitor (CPI) therapy with anti-PD1 and anti-CTLA4, when combined with LbL-IL-12-NPs, we achieved complete responses with robust immune memory induction. …”
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Peptide asparaginyl ligases—renegade peptide bond makers by Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu

“…Here we review the advances in ligases, with a focus on butelase-1, and their applications in engineering bioactive peptides and precision protein modifications, antibody-drug conjugates, and live-cell labeling.…”
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Studies of degradable ureteric stents by Huang, Yun.

“…Further studies to optimize stent design, drug delivery and mechanical properties can be done.…”
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Molecular docking and pharmacokinetics analysis of phytochemicals from Piper caninum as dengue NS2B-NS3 protease inhibitors by Mustafa, Nur Farhana Ajua, Cheng, Kian Kai, Razali, Siti Aisyah, Nadri, Muhammad Helmi

“…Analysis of in silico pharmacokinetics properties revealed that these phytochemicals have good pharmacokinetics profiles and excellent drug-abil-ity, which obeyed Lipinski’s Rule of Five. …”
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Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy by Hu, Benhui, Berkey, Christopher, Feliciano, Timothy, Chen, Xiaohong, Li, Zhuyun, Chen, Chao, Amini, Shahrouz, Nai, Mui Hoon, Lei, Qun-Li, Ni, Ran, Wang, Juan, Leow, Wan Ru, Pan, Shaowu, Li, Yong-Qiang, Cai, Pingqiang, Miserez, Ali, Li, Shuzhou, Lim, Chwee Teck, Wu, Yun-Long, Odom, Teri W., Dauskardt, Reinhold H., Chen, Xiaodong

“…Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. …”
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Synthesis of densely functionalized pyrroles from unprotected carbohydrates by Xia, Mengxin

“…The reaction methodology demonstrates a simple upcycling of carbohydrates to highly functionalized N-heterocyclic compounds. In Chapter Five, the reaction between α-hydroxyketones, oxoacetonitriles, and primary amines selectively gave N-substituted 2,3,5-functionalized 3-cyanopyrroles in up to 90% isolated yields. …”
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…In the second part, I have examined the molecular events underlying drug-induced adaptation, the process by which drug exposure inadvertently drives upregulation of pro-survival signaling pathways. …”
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Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device by Shuddhodana, Wong, Kathy Pooi Wen, Judeh, Zaher

“…It has potential to enable clinical translation of drug-loaded cochleates with predicable drug release, absorption and bioavailability.…”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

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Clinical sub-phenotypes of Staphylococcus aureus bacteraemia by Swets, MC, Bakk, Z, Westgeest, AC, Berry, K, Cooper, G, Sim, W, Lee, RS, Gan, TY, Donlon, W, Besu, A, Heppenstall, E, Tysall, L, Dewar, S, de Boer, M, Fowler, VG, Dockrell, DH, Thwaites, GE, Pujol, M, Pallarès, N, Tebé, C, Carratalà, J, Szubert, A, Groeneveld, GH, Russell, CD

“…</p> <br> <p><Strong>Results:</strong> Included patients had predominantly methicillin-susceptible SAB (1366/1430,95.5%). We identified five distinct, reproducible clinical sub-phenotypes: (A) SAB associated with older age and comorbidity, (B) nosocomial intravenous catheter-associated SAB in younger people without comorbidity, (C) community-acquired metastatic SAB, (D) SAB associated with chronic kidney disease, and (E) SAB associated with injection drug use. …”

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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The effects of different solubilizing agents on the transport and pharmacokinetic profiles of indomethacin: in vitro and in vivo approach by Siti Aisyah Zainuddin, Abdul Latip Ab Hamid, Aqila Iman Rafandi, Mashani Mohamad, Khuriah Abdul Hamid, Syed Haroon Khalid

“…Solubilizing agents, including propylene glycol, Transcutol P, Labrasol, PEG 400, and Tween 80, were separately added at 10% (v/v) to 1 mg/5 mL for in vitro diffusion chamber and 10 mg/kg body weight for in vivo oral absorption studies of indomethacin. …”
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A grid-based HIV expert system by Sloot, Peter M. A., Boukhanovsky, Alexander V., Boucher, Charles A. B., Keulen, Wilco.

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Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Microfluidics is an emerging technology vital in the bio-medical sector, encompassing LabOn-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. …”
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Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Microfluidics is an emerging technology vital in the bio-medical sector, encompassing LabOn-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. …”
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The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). …”
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