Diversity-oriented synthesis encoded by deoxyoligonucleotides

Get full text

Effect of antimicrobial agents on biofilm cells and invitro development of resistance in planktonic cells of pseudomonas aeruginosa PA01 by Balasankar Meera Priyadarshini

Get full text

Targeted therapy to gastric cancer by Hou, Qian.

“…The 8 small molecule compounds were shown to be effective in inhibiting gastric cancer cell growth at nanomolar concentrations in vitro. These drugs’ targets: HSP90, proteasome, protein phosphatase and V-ATPase provide insights for drug design trend for gastric cancer therapy. …”
Get full text

Effects of hemodynamic shear stress on circulating tumor cells by How, Yunhan

“…They also exhibit elongated cell morphology, greater drug resistance and higher expression of MnSOD, as compared to normal 231-C3.…”
Get full text

Nuclear magnetic resonance spectroscopic studies of the structure and interactions between hepatitis B virus core and surface antigens with peptides by Muhamad, Azira

“…There are several approaches in designing an antiviral drug based on the virus life cycle. This study focuses on two antiviral approaches. …”
Get full text

Magnetic Droplet Merging by Hybrid Magnetic Fields by Ray, Ayan, Varma, Vijaykumar B., Wang, Zhaomeng, Wang, Zhiping, Jayaneel, P.J., Sudharsan, Natteri M., Ramanujan, Raju V.

Get full text
Get full text

Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology by Shinozuka, K, Jerotic, K, Mediano, P, Zhao, AT, Preller, KH, Carhart-Harris, R, Kringelbach, ML

“…Pharmacologically, LSD induces significantly more inositol phosphate formation at the 5-HT2A receptor than DMT and psilocin, yet there are no significant between-drug differences in the selectivity of psychedelics for the 5-HT2A, 5-HT2C, or D2 receptors, relative to the 5-HT1A receptor. …”

Exploring crystal methamphetamine use among school-going learners: a qualitative case study in South African schools by Singwane, Thembinkosi Peter, Ramoshaba, Dillo Justin

Get full text

‘On-demand’ soft tissue adhesives by Mogal, Vishal Tukaram

“…Various plasma parameters were investigated for controlling model drug release and soft-tissue adhesion of polyester thin films. …”
Get full text

Enantioseparation with cationic β-cyclodextrin chiral stationary phases in supercritical fluid chromatography and high-performance liquid chromatography by Wang, Renqi

“…Drug chirality has attracted attention as it will influence the pharmacological activities of racemic drugs. …”
Get full text

Discovery of stabilized functional mutants of human aquaporin 1 by Soh, Miao Yi

“…In future, we hope to characterize these mutants for increased stability as they may be useful in structural studies, drug discovery in human cancers related to AQP1 overexpression as well as in biotechnological applications, such as water purification, in particular.…”
Get full text

Cationic polymer-based antimicrobial and multifunctional hydrogels for enhanced healing of infected wounds by Po, Javier Jun Fai

“…Hydrogel is made up of three-dimensional polymer matrix that is highly hydrophilic and can be used in many biomedical applications such as wound dressings and drug delivery. Its biocompatibility property provides a platform for research and development in antimicrobial wound dressings to treat microbial infections. …”
Get full text

Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…DUBs have recently garnered much respect as promising drug targets, and their roles in muscle maturation, regeneration and degeneration may provide the framework for novel therapeutics to treat muscular disorders including NMDs, sarcopenia and cachexia.…”

Activated Metals to Generate Heat for Biomedical Applications by Remlova, Eva, Feig, Vivian Rachel, Kang, Ziliang, Patel, Ashka, Ballinger, Ian, Ginzburg, Anna, Kuosmanen, Johannes, Fabian, Niora, Ishida, Keiko, Jenkins, Joshua, Hayward, Alison, Traverso, Giovanni

Get full text

Benzofuran-based estrogen receptor α modulators as anti-cancer therapeutics : in silico and experimental studies by Leow, Min Li, Chin, Christina Hui Li, Yu, Peggy Shuang, Pasunooti, Kalyan Kumar, Tay, Raymond Xu Zhan, Zhang, Dawei, Yoon, Ho Sup, Liu, Xue-Wei

“…In the search for new estrogen receptor alpha (ERα) modulators, a trial molecular screening was conducted and 5,6-dihydroxybenzofuran was identified as a possible drug target for ERα. …”
Get full text
Get full text

Sharing is caring? International Society for Pharmacoepidemiology review and recommendations for sharing programming code by Tazare, J, Wang, SV, Gini, R, Prieto Alhambra, D, Arlett, P, Morales Leaver, DR, Morton, C, Logie, J, Popovic, J, Donegan, K, Schneeweiss, S, Douglas, I, Schultze, A

“…<p><strong> Methods: </p></strong>We conducted a literature review identifying all studies published in Pharmacoepidemiology and Drug Safety (PDS) between 2017 and 2022. Data were extracted on the frequency and types of programming code shared, and other key open science practices (clinical codelist sharing, data sharing, study preregistration, and stated use of reporting guidelines and preprinting). …”

Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

Get full text

Predicting rifampicin resistance in M. tuberculosis using machine learning informed by protein structural and chemical features by Lynch, C, Adlard, D, Fowler, P

Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Valsson, Í, Warren, MT, Deane, CM, Magarkar, A, Morris, GM, Biggin, PC

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines by Stanslas, Johnson, Hagan, Damien J., Ellis, Michael J., Turner, Claire, Carmichael, James, Ward, Wynne, Hammonds, Timothy R., Stevens, Malcolm F. G.

“…Unlike m-AMSA, 14 is not susceptible to P-glycoprotein-mediated drug efflux and retains activity in lung cells with derived resistance to the topoisomerase II inhibitor etoposide.…”