Transdermal Drug Delivery by Ong, Yuhui

“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Dopamine Nation : Finding Balance in the Age of Indulgence / by Lembke, Anna, Dr., author 655980, Penguin Publishing Group (Online service) 655981

“…Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. …”
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Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy by Lewis, Benjamin B.

“…The opening of medical marijuana dispensaries and the passage of recreational marijuana legalization laws also had no significant overall effect on overdose death rates, but the effect of these policies varied significantly across states such that there were significant increases in some states and significant decreases in others. Overall, these findings contradict the popular claim that marijuana decriminalization leads to increased use of more dangerous drugs (and thus overdose deaths) in most cases – and more generally questions the characterization of marijuana as a gateway drug.…”
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Liposomal encapsulation of pro-NO donor drug by Koh, Cheryl Jie Yan

“…Liposomes are utilised as drug carrier due to its biocompatibility and inert nature in the physiological body, to protect the drug as well as prevent premature elimination by the body. …”
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Collection and analysis on data from Drugs.com by Aw, Teng Teng

“…In this report, Scrapy, is a web scraper, which will be used to extract data from Drugs.com. Scrapy is a framework, done in Python and the outputs will be saved in JSON files. …”
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Nanosized silica particles for chiral drug separation by Tan, Timothy Thatt Yang.

“…The current work addresses the urgent need of novel stationary phases for rapid enantionseparation, and it complements and supports the projects by the PI in the synthesis and application of nanoparticles for achiral and chiral drug separation. The emphasis of this work lies on nanoparticle synthesis and functionalization. …”
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Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

“…Although the aerobic cytochrome bd respiratory branch is not strictly essential for growth, the discovery of a strong synthetic lethal interaction with the cytochrome bcc-aa3 placed the cytochrome bd oxidase under the spotlight as an attractive drug target for its synergistic role in potentiating the efficacy of cytochrome bcc-aa3 inhibitors and other drugs targeting oxidative phosphorylation. …”
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Cellular response to synthetic drugs : a metabolomics approach by Chen, William Wei Ning.

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Re-understanding the mechanisms of action of the anti-mycobacterial drug bedaquiline by Sarathy, Jickky Palmae, Gruber, Gerhard, Dick, Thomas

“…However, this mechanism is controversial as the drug’s binding affinity for the isolated ε-subunit protein is moderate and spontaneous resistance mutants in the ε-subunit cannot be isolated. …”
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Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria by Dahal, P

“…</p> <p>This thesis highlighted that the choice of analytical approaches led to variability around the derived estimates of drug efficacy. The findings of this thesis are discussed with regards to current World Health Organization guidance to change treatment policy.…”

Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes by Low, Jianrong L., Gehring, Adam J., Kranz, David M., Grotenbreg, Gijsbert M., Yau, Yin Hoe, Shochat, Susana Geifman, Bertoletti, Antonio, Naidoo, Anneta, Yeo, Gladys, Ho, Zi Zong

“…Various protein scaffolds have been designed to recapitulate the specific recognition of presented antigens with the aim to be exploited both diagnostically (e.g. to visualize cells exposed to infectious agents or cellular transformation) and therapeutically (e.g. for the delivery of drugs to compromised cells). In line with this, we report the construction of a soluble tetrameric form of an αβ T cell receptor (TCR) specific for the HBV epitope Env183–191 restricted by HLA-A*02:01, and compare its avidity and fine-specificity with a TCR-like monoclonal antibody generated against the same HLA target. …”
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Antibiotic resistance profile, potential drivers and genotype of Escherichia coli, Salmonella sp. and Vibrio sp. isolated from hybrid red tilapia and Asian seabass in the West Coas... by Dewi, Rita Rosmala

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Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”

Computational screening of FDA-approved hepatitis c drugs for inhibition of VEGFR2 in liver cancer by Roney, Miah, Issahaku, Abdul Rashid, Tufail, Nasir, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…All things considered, this study will help the scientific community and society find a novel drug to treat LC.…”
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Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles toward Virucidal Drug Evaluation by Jackman, Joshua Alexander, Linardy, Eric, Yoo, Daehan, Seo, Jeongeun, Ng, Wei Beng, Klemme, Daniel J., Wittenberg, Nathan J., Oh, Sang-Hyun, Cho, Nam-Joon

“…A plasmonic nanohole sensor for virus-like particle capture and virucidal drug evaluation is reported. Using a materials-selective surface functionalization scheme, passive immobilization of virus-like particles only within the nanoholes is achieved. …”
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Synergistic antibacterial effect of Persicaria odorata synthesised silver nanoparticles with antibiotics on drug-resistant bacteria. by Abdul Hadi, Atieya, Nik Malek, Nik Ahmad Nizam, Matmin, Juan, Asraf, Muhammad Hariz, Susanto, Hendra, Mohammad Din, Shahrulnizahana, Shamsuddin, Mustaffa

Rationalisation of antifungal properties of α-helical pore-forming peptide, mastoparan B by Lim, Edward Jianyang, Goh, Eunice Tze Leng, Tram, Nhan Dai Thien, Periayah, Mercy Halleluyah, Ee, Rachel Pui Lai, Barkham, Timothy Mark Sebastian, Poh, Zhi Sheng, Verma, Navin Kumar, Lakshminarayanan, Rajamani

“…We show that MB susceptibility of phylogenetically distant non-candida albicans can vary and be described by different intrinsic physicochemical parameters of pore-forming α-helical peptides. These findings have potential therapeutic implications for the design and development of safe antifungal peptide-based drugs.…”
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Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery by Zhang, Fengying, Ngoc, Nguyen Thi Quynh, Tay, Bao Hui, Mendyk, Aleksander, Shao, Yu-Hsuan, Lau, Raymond

“…SEM images coupled with image analysis software reveal that different surface morphology of the microparticles have different drug adhesion mechanisms. Comparison of ACI results and image analysis of SEM images shows that an increase in the particle surface roughness can increase the fine particle fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. …”
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Proteomic network of antibiotic-induced outer membrane vesicles released by extensively drug-resistant Elizabethkingia anophelis by Chiang, Ming-Hsien, Chang, Fang-Ju, Kesavan, Dinesh Kumar, Vasudevan, Aparna, Xu, Huaxi, Lan, Kuo-Lun, Huang, Shu-Wei, Shang, Hung-Sheng, Chuang, Yi-Ping, Yang, Ya-Sung, Chen, Te-Li

“…In this study, we sought to understand the characteristics of E. anophelis OMVs under different antibiotic stress conditions. An extensively drug-resistant clinical isolate, E. anophelis C08, was exposed to multiple antibiotics in vitro, and its OMVs were characterized using nanoparticle tracking analysis, transmission electron microscopy, and proteomic analysis. …”
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