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Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes
Published 2013“…Various protein scaffolds have been designed to recapitulate the specific recognition of presented antigens with the aim to be exploited both diagnostically (e.g. to visualize cells exposed to infectious agents or cellular transformation) and therapeutically (e.g. for the delivery of drugs to compromised cells). In line with this, we report the construction of a soluble tetrameric form of an αβ T cell receptor (TCR) specific for the HBV epitope Env183–191 restricted by HLA-A*02:01, and compare its avidity and fine-specificity with a TCR-like monoclonal antibody generated against the same HLA target. …”
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Journal Article -
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Collection and analysis on data from Drugs.com
Published 2017“…In this report, Scrapy, is a web scraper, which will be used to extract data from Drugs.com. Scrapy is a framework, done in Python and the outputs will be saved in JSON files. …”
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Final Year Project (FYP) -
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Nanosized silica particles for chiral drug separation
Published 2010“…The chiral compounds can be separated but future work needs to be done to fine-tune the nanoparticles properties to optimize separation efficiencies. …”
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Research Report -
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Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery
Published 2016“…SEM images coupled with image analysis software reveal that different surface morphology of the microparticles have different drug adhesion mechanisms. Comparison of ACI results and image analysis of SEM images shows that an increase in the particle surface roughness can increase the fine particle fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. …”
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Journal Article -
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AI is a viable alternative to high throughput screening: a 318-target study
Published 2024Get full text
Journal Article -
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Overcoming endurance issue : UAV-enabled communications with proactive caching
Published 2019“…Specifically, we focus on content-centric communication systems, where a UAV is dispatched to serve a group of ground nodes (GNs) with random and asynchronous requests for files drawn from a given set. With the proposed scheme, at the beginning of each operation period, the UAV pro-actively transmits the files to a subset of selected GNs that cooperatively cache all the files. …”
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Journal Article -
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21W.775 Writing about Nature and Environmental Issues, Spring 2006
Published 2006“…Authors include Henry Thoreau, Loren Eiseley, Annie Dillard, Chet Raymo, Sue Hubbel, Rachel Carson, Bill McKibben, and Terry Tempest Williams.…”
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Learning Object -
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Development of multimedia educational software
Published 2013“…While this educational software was developed by using Visual Basic programming, graphical presentations and 3D images were drawn by using Autodesk Revit and were exported to Visual Basic as image files for creation of animations.…”
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Final Year Project (FYP) -
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Instability Scaffolding: Enacting Strategic Instabilities to Produce Authentic Premium Wine
Published 2024“…My dissertation explores how strategic instabilities are enacted in productions of fine wine, articulating the practices and arrangements that facilitate working with unstable production conditions in productive ways—a process I refer to as instability scaffolding. …”
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Thesis -
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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study...
Published 2024“…</p> <br> <p><strong>Funding:</strong> Wellcome Trust, Bill & Melinda Gates Foundation, EU Horizon 2020, and UK National Institute for Health and Care Research.…”
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