MicroRNAs in tissue engineering & regenerative medicine by Chew, Sing Yian

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Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia by Srisutham, S, Saejeng, A, Khantikul, N, Sugaram, R, Sangsri, R, Dondorp, AM, Day, NPJ, Imwong, M

“…Previous studies revealed a high prevalence of key mutations, including C580Y, P574L, and R561H, emphasizing the need for the surveillance to combat drug resistance. This study, we developed a droplet digital PCR (ddPCR) assay for the rapid screening of common mutations including P441L, Y493H, P527H, G538V, R539T, I543T, R561H, P574L, C580Y, and A675V. …”

Synthesis of chiral sulfinate esters by asymmetric condensation by Zhang, Xin, Ang, Esther Cai Xia, Yang, Ziqi, Kee, Choon Wee, Tan, Choon-Hong

“…Achiral sulfur functional groups, such as sulfonamide, sulfone, thiol and thioether, are common in drugs and natural products. By contrast, chiral sulfur functional groups are often neglected as pharmacophores1-3, although sulfoximine, with its unique physicochemical and pharmacokinetic properties4,5, has been recently incorporated into several clinical candidates. …”
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Investigation of blood pressure regulation schemes by Chai, Chang Yong

“…Hence, continuous monitoring and careful control of the infusion of drug is required. Since the middle 1970s, many researches have been conducted using various types of feedback control system to regulate blood pressure through the infusion of antihypertension drug [5]. …”
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Optimal pre-analysis plans: statistical decisions subject to implementability by Kasy, M, Spiess, J

A biodegradable ocular implant for long-term suppression of intraocular pressure by Ng, Xu Wen, Liu, Kerh Lin, Veluchamy, Amutha Barathi, Lwin, Nyein Chan, Wong, Tina T., Venkatraman, Subbu Subramanian

“…However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage, and lack of patient compliance. Suboptimal control of the IOP leads to disease progression and eventually to blindness. …”
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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

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Sustained Release of Cx43 Antisense Oligodeoxynucleotides from Coated Collagen Scaffolds Promotes Wound Healing by Gilmartin, Daniel J., Soon, Allyson, Thrasivoulou, Christopher, Phillips, Anthony R. J., Jayasinghe, Suwan N., Becker, David Lawrence

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Towards depth-resolved multi-cubic-centimeter field of view endoscopic camera for intraoperative nerve identification. by Yoon, Yong-Chul

“…One out of every five peripheral nerve injuries in the United States has an iatrogenic origin. …”
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Structural and biochemical characterisation of bacterial metallo-β-lactamases by Makena, A

“…</p> <p>The Verona imipenemase metallo-β-lactamases (VIM) enzymes are among the most widely distributed MBLs with &amp;GT;40 variants reported (Chapter 5). Comparative studies on the biochemical and biophysical properties were carried out for five VIM variants: VIM-1, VIM- 2, VIM-4, VIM-5 and VIM-38. …”

Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures by Cardoso da Costa, Leticia

“…The difference in backbone degradation rates, imparted by the silyl ether substituents, leads to different drug release profiles and therapeutic efficacy in vitro (Chapter 3). …”
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Antimicrobial efficacy testing of antibiotic-containing biodegradable nanopolymers against biofilm and planktonic cells. by Polimyr Caesar Dave Pelisco Dingal.

“…With efficient use of drug-encapsulated nanopolymers, bactericidal dosages are sufficiently lowered and dosing intervals can be extended due to the sustained drug release feature afforded by these efficacious nanocarriers.…”
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Methamphetamine abuse in Malaysia: an interpretive phenomenological perspective by Audi Azizul, Muhd Dhamir, Wan Jaafar, Wan Munira, Mohd Khir, Azlina, Amin, Samir Muhazzab

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Polymers at Nanoscale / by He, Jie, editor 655466, Wang, Xin, editor 655467, World Scientific (Online service) 655444

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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…MetS was defined as having three or more of the following five abnormalities: hypertriglyceridemia, HDL hypocholesterolemia, hypertension, obesity, and diabetes. …”
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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles by Nguyen, Thuy-Khanh, Selvanayagam, Ramona, Ho, Kitty K. K., Chen, Renxun, Kutty, Samuel K., Rice, Scott A., Kumar, Naresh, Barraud, Nicolas, Duong, Hien T. T., Boyer, Cyrille

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Data-Driven Classification of Pharmaceutical and Biotechnology Companies by Xu, Angelina

“…We use fundamental financial data, 10-K filings, and company drug development data to develop this new classification scheme. …”
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In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus by Nagarajan, Nagasundaram, Yapp, Edward Kien Yee, Le, Nguyen Quoc Khanh, Yeh, Hui-Yuan

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Cytotoxicity and mechanisms of action of Zerumbone-loaded nanostructured lipid carrier in triple negative breast cancer cells, MDA-MB-231 by Hosseinpour, Mahnaz

“…According to the Malaysian National Cancer Registry (2006), breast cancer is one of the five most common cancers amongst Malaysian women. …”
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