Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay

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Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr by Zhang, Yingdan, Chew, Alvin Bing Liang, Wang, Jing, Yuan, Mingjun, Yam, Joey Kuok Hoong, Luo, Dahai, Yang, Liang

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Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Odds ratios for HRT types, adjusted for personal characteristics, smoking status, alcohol consumption, comorbidities, family history, and other prescribed drugs. Separate results from QResearch or CPRD were combined. …”

Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents by Zhang, Kaixi, Raju, Cheerlavancha, Zhong, Wenbin, Pethe, Kevin, Gründling, Angelika, Chan-Park, Mary B.

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Discovery and characterization of hevein-like peptides in functional food and medicinal plants by Tay, Stephanie Victoria Choo Gek

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Biointerface design for vertical nanoprobes by Elnathan, Roey, Barbato, Maria Grazia, Guo, Xiangfu, Mariano, Anna, Wang, Zixun, Santoro, Francesca, Shi, Peng, Voelcker, Nicolas H., Xie, Xi, Young, Jennifer L., Zhao, Yunlong, Zhao, Wenting, Chiappini, Ciro

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Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice by Traut, J, Mengual, JP, Meijer, E, McKillop, L, Alfonsa, H, Hoerder-Suabedissen, A, Song, SH, Fehér, KD, Riemann, D, Molnar, Z, Akerman, CJ, Vyazovskiy, VV, Krone, LB

“…Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. …”

Optical coherence tomography angiography imaging to monitor anti-VEGF treatment of corneal vascularization in a rabbit model by Devarajan, Kavya, Ong, Hon Shing, Lwin, Nyein C., Chua, Jacqueline, Schmetterer, Leopold, Mehta, Jodhbir Singh, Ang, Marcus

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Patients’ experience of medication brand changes during hormone therapy for breast cancer: an interpretative phenomenological analysis by Eraso, Yolanda, Moon, Zoe, Steinberga, Ieva

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Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality by Kashyap, Rajan, Bhattacharjee, Sagarika, Yeo, Thomas B. T., Chen, Annabel Shen-Hsing

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Defending, contesting and rejecting formal drinker categories: how UK university students identify as ‘light-drinkers’ or ‘non-drinkers’ by Conroy, Dom, Griffin, Christine, Morton, Charlotte

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The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis by Singh, S, Boyd, S, Schilling, WHK, Watson, JA, Mukaka, M, White, NJ

“…<p><strong>Background:&nbsp;</strong>Effective antiviral drugs accelerate viral clearance in acute COVID-19 infections; the relationship between accelerating viral clearance and reducing severe clinical outcomes is unclear.…”

Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

Hydroxyapatite nanoparticles-cell interaction: new approaches to disclose the fate of membrane-bound and internalised nanoparticles by Bonany, Mar, Pérez-Berná, Ana Joaquina, Dučić, Tanja, Pereiro, Eva, Martin-Gómez, Helena, Mas-Moruno, Carlos, van Rijt, Sabine, Zhao, Zhitong, Espanol, Montserrat, Ginebra, Maria-Pau

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Development of axially chiral urazole scaffolds for antiplant virus applications against potato virus Y by Jin, Jiamiao, Mou, Chengli, Zou, Juan, Xie, Xin, Wang, Chen, Shen, Tingwei, Deng, Youlin, Li, Benpeng, Jin, Zhichao, Li, Xiangyang, Chi, Robin Yonggui

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Enantioselective epoxidation of protected allylic and homoallylic amines via chiral cationic ion-pairing catalysis by Chin, Kek Foo

“…The derivatives of the epoxidised product, amino alcohols, are present in scaffold of many drugs or nature products. Hence, an efficient and effective methodology for asymmetric epoxidation on allylic amines is highly desirable. …”
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Inorganic nanoparticles–driven self–assembly of natural small molecules in water for constructing multifunctional nanocapsules against plant diseases by Liu, Li-Wei, Ding, Zheng-Hao, Ren, Gang-Gang, Wang, Guang-Di, Pan, Xin, Wei, Guo-Hai, Zhou, Xiang, Wu, Zhi-Bing, Jin, Zhi-Chao, Chi, Robin Yonggui, Yang, Song

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In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Tannic acid (TA), a phenolic compound found in medicinal plants, has shown promising efficacy in enhancing chemotherapeutic drugs against various cancers. Hence, this study aimed to investigate the effect of TA treatment combined with cisplatin on human osteosarcoma cell line (U2OS). …”
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Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head by Loo, Jing Hong, Lee, Ying Shi, Woon, Chang Yi, Yong, Victor H. K., Tan, Bingyao, Schmetterer, Leopold, Chong, Rachel S.

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Structural and mechanistic studies of herpes virus proteins by Patel, Vidhi Kanaiyalal

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