Can we please have some honesty about drugs by Saad ul Hassan Hashmi

“…Finally, in section four, I will discuss contemporary research on drugs. In section five, I consider more objections to the arguments I have made and draw a final conclusion: that policy should be framed based on evidence.…”
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Exploring TNFi drug-levels and anti-drug antibodies during tapering among patients with inflammatory arthritis: secondary analyses from the randomised BIODOPT trial by Uhrenholt, L, Sørensen, MER, Lauridsen, KB, Duch, K, Dreyer, L, Christensen, R, Hauge, E-M, Loft, AG, Rasch, MNB, Horn, HC, Taylor, PC, Nielsen, KR, Kristensen, S

“…Between baseline and month 18, a significant shift in TNFi drug-levels were observed in the tapering group resulting in fewer patients with high drug-levels (change: − 14% [95% CI − 27 to − 1%]) and more with low drug-levels (change: 18% [95% CI 5–31%]). …”

Toxicity, permeability and drug-metabolizing enzyme activities of curcumin analogues by Yakubu, Ndatsu

“…To ascertain the toxicity,permeability and drug-metabolizing enzyme activities of BDMC33 and MS65, their in vitro toxicity test at (0-400 μM) on Caco-2 cells using MTT assay, the in vivo toxicity test on zebrafish embryos and larvae at (0-50 μM), and acute toxicity effects (0-30 μM) on adult male zebrafish were investigated for 5 hr, 5 days, and 48 hr of exposure, respectively. …”
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Development of biomimetic 3D cancer platform for drug testing by Ker, Sia Fong

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Liposomal carrier systems for encapsulation of drugs using bicellar mixtures by Lee, Bao Jun

“…This research aims to evaluate the physicochemical properties of bicelles, such as particle size, distribution, and encapsulation efficiency of drugs. The bicelles will be fabricated using the LUCA cycles (freeze-thaw-vortex cycles) by varying the q-ratio (0, 2, 5, 8, 10, and 20) and total lipid concentration (2mM, 5mM and 10mM). …”
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Silk Fibroin-Based Coatings for Pancreatin-Dependent Drug Delivery by Navamajiti, Natsuda, Gardner, Apolonia, Cao, Ruonan, Sugimoto, Yutaro, Yang, Jee Won, Lopes, Aaron, Phan, Nhi V., Collins, Joy, Hua, Tiffany, Damrongsakkul, Siriporn, Kanokpanont, Sorada, Steiger, Christoph, Reker, Daniel, Langer, Robert, Traverso, Giovanni

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Novel drug-eluting stent to reduce fibrosis-induced ureteral stricture by Fong, Timothy Ren Zhong

“…A solution of poly(L-lactide-co-caprolactone) and MMC was spray coated on 2cm long polyurethane stents, with varied drug loading (2.5wt%, 5wt%, 7.5wt%). The stents were then immersed in four different Phosphate Buffer Saline mediums (pH 6, 7, 7.4, 8.5) for drug release over 28 days. …”
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Pathways to prison: economic, personal and relational motivations for drug offending in Indonesia by Hoyle, C, Jabbar, P

Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems by Leu, Jassica S. L., Teoh, Jasy J. X., Ling, Angel L. Q., Chong, Joey, Loo, Yan Shan, Mat Azmi, Intan Diana, Zahid, Noor Idayu, Bose, Rajendran J. C., Madheswaran, Thiagarajan

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Green amorphous nanoplex as a new supersaturating drug delivery system by Cheow, Wean Sin, Hadinoto, Kunn

“…The solubility of curcumin as the least-soluble drug is magnified 9-fold upon its transformation to the nanoplex, and the supersaturated condition is maintained for 5 h.…”
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Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release by Field, Rachel D, Jakus, Margaret A, Chen, Xiaoyu, Human, Kelia, Zhao, Xuanhe, Chitnis, Parag V, Sia, Samuel K

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Layer-by-layer assembled micro and nano carriers for drug delivery applications by Mutukumaraswamy Shaillender

“…In nano- or microparticulate drug delivery, both control of the drug release and interaction of the particles with the cellular environment are critical attributes. …”
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Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

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Exploring drug consumption rooms as ‘inclusion health interventions’: policy implications for Europe by Scher, BD, Chrisinger, BW, Humphreys, DK, Shorter, GW

Development of oil-based gels as versatile drug delivery systems for pediatric applications by Kirtane, Ameya R., Karavasili, Christina, Wahane, Aniket, Freitas, Dylan, Booz, Katelyn, Le, Dao Thi Hong, Hua, Tiffany, Scala, Stephen, Lopes, Aaron, Hess, Kaitlyn, Collins, Joy, Tamang, Siddartha, Ishida, Keiko, Kuosmanen, Johannes L. P., Rajesh, Netra Unni, Phan, Nhi V., Li, Junwei, Krogmann, Annlyse, Lennerz, Jochen K., Hayward, Alison, Langer, Robert, Traverso, Giovanni

“…In swine, oleogels could deliver four drugs ranging three orders of magnitude in their water solubilities and two orders of magnitude in their partition coefficients. …”
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Electrochemically driven optical and SERS immunosensor for the detection of a therapeutic cardiac drug by Chaudhry, Madeeha, Lim, Dong-Kwon, Kang, Jeon Woong, Yaqoob, Zahid, So, Peter, Bhopal, Muhammad Fahad, Wang, Minqiang, Qamar, Raheel, Bhatti, Arshad Saleem

“…The effectiveness of the drug critically depends on its presence in the therapeutic range (0.8–2.0 ng mL−1) in the patient's serum. …”
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Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis by Wang, C

“…<p>Tuberculosis is a highly lethal infectious disease, causing approximately 1.5 million deaths annually. Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”

Flame-made calcium phosphate nanoparticles with high drug loading for delivery of biologics by Tsikourkitoudi, Vasiliki, Karlsson, Jens, Merkl, Padryk, Loh, Edmund, Henriques-Normark, Birgitta, Sotiriou, Georgios A.

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Structural basis of ligand recognition in 5-HT3 receptors by Thompson, Andrew J., Villalgordo, Jose M., Lummis, Sarah C. R., Smit, August B., Kesters, Divya, Elk, René van, Brams, Marijke, Spurny, Radovan, Geitmann, Matthis, Guskov, Albert, Danielson, U. Helena, Ulens, Chris

“…The 5-HT3 receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. …”
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Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”