Homology modeling and expression of recombinant NS5-RDRP based on the Indonesian local strain of dengue virus for anti-dengue drug development by Subroto, Toto, Firdaus, Ade Rizqi Ridwan, Kusumawardani, Shinta, Tohari, Taufik Ramdani, Nababan, Theresia Adventina, Pertiwi, Wulan, Fadhlillah, Muhammad, Kusuma, Sri Agung Fitri, Rukayadi, Yaya

“…As a result, the RdRp gene, which belongs to the non-structural protein 5 (NS5) of DENV, was successfully isolated and sequenced from DENV RNA samples. …”
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Transdermal Drug Delivery by Ong, Yuhui

“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy by Lewis, Benjamin B.

“…Drug criminalization has disproportionately impacted communities of color and has insufficiently addressed substance use disorder and its associated risk of death through overdosing. …”
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Article 28 - Drug abuse by Sloth-Nielsen, R

Millifluidic synthesis of amorphous drug-polysaccharide nanoparticle complex with tunable size intended for supersaturating drug delivery applications by Tran, The-Thien, Nguyen, Minh-Hiep, Tan, Yong Zen, Chew, Jia Wei, Khan, Saif A., Hadinoto, Kunn

“…The conventional bulk mixing method to prepare amorphous drug-polysaccharide nanoparticle complex (or drug nanoplex in short) has a major drawback in the lack of size control for the nanoplex produced, hence limiting its potential applications as a supersaturating drug delivery system for bioavailability enhancement of poorly soluble drugs. …”
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Collection and analysis on data from Drugs.com by Aw, Teng Teng

“…In this report, Scrapy, is a web scraper, which will be used to extract data from Drugs.com. Scrapy is a framework, done in Python and the outputs will be saved in JSON files. …”
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Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

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Drug-eluting scaffolds for bone and cartilage regeneration by Lee, Wei Li, Loo, Say Chye Joachim, Huang, Charlotte L.

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Evaluation of drug reproductive toxicity and the underlying mechanisms by Wu, Sixian, Shang, Lijun, Xu, Wenming

Enzyme-responsive nanoparticles for drug release and diagnostics by Rica, Roberta de la, Aili, Daniel, Stevens, Molly M.

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1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity by Yang, Xuan, Wedajo, Wassihun, Yamada, Yoshiyuki, Dahlroth, Sue-Li, Neo, Jason Jun-Long, Dick, Thomas, Chui, Wai-Keung

“…The emergence of multi- and extensively-drug resistant tubercular (MDR- and XDR-TB) strains of mycobacteria has limited the use of existing therapies, therefore new drugs are needed. …”
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Search for Heavy Narrow Dilepton Resonances in Pp Collisions at √s = 7 TeV and √s = 8 TeV by Apyan, Aram, Bendavid, Joshua L., Busza, Wit, Butz, Erik M., Cali, Ivan Amos, Chan, M., Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Kim, Y., Klute, Markus, Krajczar, Krisztian F., Ma, Teng, Nahn, Steven, Paus, Christoph M. E., Ralph, Duncan Kelley, Rudolph, Matthew Scott, Stephans, George S. F., Sung, Kevin Kai Hong, Velicanu, Dragos Alexandru, Wenger, Edward Allen, Wyslouch, Boleslaw, Yilmaz, Yetkin, Yoon, A. S., Zanetti, Marco, Bauer, Gerry P, Dutta, Valentina, Levin, Andrew Michael, Roland, Christof E, Stoeckli, Fabian, Luckey Jr, P David, Roland, Gunther M, Sumorok, Konstanty C, Wolf, Roger, Yang, Mingming, Wyslouch, Victoria

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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…</p> <p>The COVID-19 pandemic highlighted again the lack of broad-spectrum antivirals available to patients before thorough investigation of an emergent virus, such as its genome or target host receptor. Chapter 5 discusses the establishment of a medium-throughput drug screening platform against SARS-CoV-2. …”

18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…<b>Chapter 2</b> describes a novel silver-mediated ¹⁸F-labelling of Ar-SCF3, Ar OCF3 and Ar-OCF2H, including [¹⁸F]Riluzole, the ¹⁸F labelled version of a drug for treatment of amyotrophic lateral sclerosis (ALS). …”

Mycobacterium tuberculosis drug resistance detection by pyrosequencing method by Goh, Mei Ling

“…The conventional way of detecting Mycobacterium tuberculosis and its resistance is by culture followed by phenotypic drug susceptibility testing. This laborious process usually takes 4 to 12 weeks due to the slow growing nature of the organism. …”
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Dengue Virus Non-Structural Protein 5 by El Sahili, Abbas, Lescar, Julien

“…This review focuses on recent progress in characterizing the structure and functions of NS5, a protein responsible for the replication and capping of viral RNA that represents a promising drug target.…”
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Can we please have some honesty about drugs by Saad ul Hassan Hashmi

“…Finally, in section four, I will discuss contemporary research on drugs. In section five, I consider more objections to the arguments I have made and draw a final conclusion: that policy should be framed based on evidence.…”
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Exploring TNFi drug-levels and anti-drug antibodies during tapering among patients with inflammatory arthritis: secondary analyses from the randomised BIODOPT trial by Uhrenholt, L, Sørensen, MER, Lauridsen, KB, Duch, K, Dreyer, L, Christensen, R, Hauge, E-M, Loft, AG, Rasch, MNB, Horn, HC, Taylor, PC, Nielsen, KR, Kristensen, S

“…Between baseline and month 18, a significant shift in TNFi drug-levels were observed in the tapering group resulting in fewer patients with high drug-levels (change: − 14% [95% CI − 27 to − 1%]) and more with low drug-levels (change: 18% [95% CI 5–31%]). …”

Toxicity, permeability and drug-metabolizing enzyme activities of curcumin analogues by Yakubu, Ndatsu

“…To ascertain the toxicity,permeability and drug-metabolizing enzyme activities of BDMC33 and MS65, their in vitro toxicity test at (0-400 μM) on Caco-2 cells using MTT assay, the in vivo toxicity test on zebrafish embryos and larvae at (0-50 μM), and acute toxicity effects (0-30 μM) on adult male zebrafish were investigated for 5 hr, 5 days, and 48 hr of exposure, respectively. …”
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Development of biomimetic 3D cancer platform for drug testing by Ker, Sia Fong

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