Synthesis of densely functionalized pyrroles from unprotected carbohydrates by Xia, Mengxin

“…The reaction methodology demonstrates a simple upcycling of carbohydrates to highly functionalized N-heterocyclic compounds. In Chapter Five, the reaction between α-hydroxyketones, oxoacetonitriles, and primary amines selectively gave N-substituted 2,3,5-functionalized 3-cyanopyrroles in up to 90% isolated yields. …”
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Surface modified polymers for controlled macroscopic functions by Chng, S

“…A library of polymers with variation in end group, and with expansion of substrate scope, was characterised in detail for chemical and macroscopic properties. In particular, drug delivery properties were investigated using hole-plate bioassays and HPLC-MS methods, and it was found that the antibiotic, Penicillin V, was still active after being loaded onto the polymer scaffolds, with surface modified polymers binding and releasing more drug than the corresponding controls. …”

Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device by Shuddhodana, Wong, Kathy Pooi Wen, Judeh, Zaher

“…It has potential to enable clinical translation of drug-loaded cochleates with predicable drug release, absorption and bioavailability.…”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

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Clinical sub-phenotypes of Staphylococcus aureus bacteraemia by Swets, MC, Bakk, Z, Westgeest, AC, Berry, K, Cooper, G, Sim, W, Lee, RS, Gan, TY, Donlon, W, Besu, A, Heppenstall, E, Tysall, L, Dewar, S, de Boer, M, Fowler, VG, Dockrell, DH, Thwaites, GE, Pujol, M, Pallarès, N, Tebé, C, Carratalà, J, Szubert, A, Groeneveld, GH, Russell, CD

“…</p> <br> <p><Strong>Results:</strong> Included patients had predominantly methicillin-susceptible SAB (1366/1430,95.5%). We identified five distinct, reproducible clinical sub-phenotypes: (A) SAB associated with older age and comorbidity, (B) nosocomial intravenous catheter-associated SAB in younger people without comorbidity, (C) community-acquired metastatic SAB, (D) SAB associated with chronic kidney disease, and (E) SAB associated with injection drug use. …”

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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The effects of different solubilizing agents on the transport and pharmacokinetic profiles of indomethacin: in vitro and in vivo approach by Siti Aisyah Zainuddin, Abdul Latip Ab Hamid, Aqila Iman Rafandi, Mashani Mohamad, Khuriah Abdul Hamid, Syed Haroon Khalid

“…Solubilizing agents, including propylene glycol, Transcutol P, Labrasol, PEG 400, and Tween 80, were separately added at 10% (v/v) to 1 mg/5 mL for in vitro diffusion chamber and 10 mg/kg body weight for in vivo oral absorption studies of indomethacin. …”
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A grid-based HIV expert system by Sloot, Peter M. A., Boukhanovsky, Alexander V., Boucher, Charles A. B., Keulen, Wilco.

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The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). …”
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Delay-and-pay: prolonging pharmaceutical patent protection without paying the ‘price’ by Foss-Solbrekk, K

Psychotropic taxonomies: constructing a therapeutic framework for psychiatry by McCutcheon, RA, Cowen, P, Nour, MM, Pillinger, T

MicroRNAs in tissue engineering & regenerative medicine by Chew, Sing Yian

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Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia by Srisutham, S, Saejeng, A, Khantikul, N, Sugaram, R, Sangsri, R, Dondorp, AM, Day, NPJ, Imwong, M

“…Previous studies revealed a high prevalence of key mutations, including C580Y, P574L, and R561H, emphasizing the need for the surveillance to combat drug resistance. This study, we developed a droplet digital PCR (ddPCR) assay for the rapid screening of common mutations including P441L, Y493H, P527H, G538V, R539T, I543T, R561H, P574L, C580Y, and A675V. …”

Synthesis of chiral sulfinate esters by asymmetric condensation by Zhang, Xin, Ang, Esther Cai Xia, Yang, Ziqi, Kee, Choon Wee, Tan, Choon-Hong

“…Achiral sulfur functional groups, such as sulfonamide, sulfone, thiol and thioether, are common in drugs and natural products. By contrast, chiral sulfur functional groups are often neglected as pharmacophores1-3, although sulfoximine, with its unique physicochemical and pharmacokinetic properties4,5, has been recently incorporated into several clinical candidates. …”
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Investigation of blood pressure regulation schemes by Chai, Chang Yong

“…Hence, continuous monitoring and careful control of the infusion of drug is required. Since the middle 1970s, many researches have been conducted using various types of feedback control system to regulate blood pressure through the infusion of antihypertension drug [5]. …”
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Optimal pre-analysis plans: statistical decisions subject to implementability by Kasy, M, Spiess, J

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

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Sustained Release of Cx43 Antisense Oligodeoxynucleotides from Coated Collagen Scaffolds Promotes Wound Healing by Gilmartin, Daniel J., Soon, Allyson, Thrasivoulou, Christopher, Phillips, Anthony R. J., Jayasinghe, Suwan N., Becker, David Lawrence

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Towards depth-resolved multi-cubic-centimeter field of view endoscopic camera for intraoperative nerve identification. by Yoon, Yong-Chul

“…One out of every five peripheral nerve injuries in the United States has an iatrogenic origin. …”
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Structural and biochemical characterisation of bacterial metallo-β-lactamases by Makena, A

“…</p> <p>The Verona imipenemase metallo-β-lactamases (VIM) enzymes are among the most widely distributed MBLs with &amp;GT;40 variants reported (Chapter 5). Comparative studies on the biochemical and biophysical properties were carried out for five VIM variants: VIM-1, VIM- 2, VIM-4, VIM-5 and VIM-38. …”