Transdermal Drug Delivery by Ong, Yuhui

“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Compounds of a global anti-COVID-19 effort called the “Moonshot project” targeting the main protease of SARS-CoV-2 were also screened and promising compounds were progressed further to produce a specific direct-acting SARS-CoV-2 antiviral compound. …”

Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis by Wang, C

“…Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”

A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY) by Karadzas, M

“…</p> <p>Recently, a powerful transposon sequencing method was developed in Saccharomyces cerevisiae, called SAturated Transposon Analysis in Yeast (SATAY). …”

Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…In part II, my first project is the development of novel drug-loaded nanogels for pH sensitive drug release, which will be described in chapter 3. …”
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RES.10-001 Making Science and Engineering Pictures, Fall 2014 by Frankel, Felice C.

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Targeting NAPE-PLD: assessing its potential in the fight against malaria by Goh, Xiu Ling

“…Malaria remains a major global challenge with increasing artemisinin-resistant Plasmodium falciparum. This calls for an increased need for discovering novel ring-stage drug targets. …”
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Antimicrobial efficacy testing of antibiotic-containing biodegradable nanopolymers against biofilm and planktonic cells. by Polimyr Caesar Dave Pelisco Dingal.

“…Cystic fibrosis and rampant urogenital infections, caused by increasingly resistant microbial biofilms, call for more creative anti-infective systems. This study investigated the in vitro efficacy of levofloxacin (LEV)–loaded poly(D,L-lactide-co-glycolide) (PLGA) and poly-ε-caprolactone (PCL) nanopolymers against optimally-grown biofilms of Escherichia coli K12 W3110 and Pseudomonas aeruginosa PA01. …”
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Development of red/near-infrared fluorescent molecules and macromolecules for biomedical applications by Yang, Cangjie

“…A strong candidate for clinical theranostics also calls for the improvement in optical properties of R/NIR imaging agents. …”
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Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics by Wilde, Joshua T., Springs, Stacy, Wolfrum, Jacqueline M., Levi, Retsef

“…We propose a data-driven signal detection method called HMMScan to monitor for manufacturing lot-dependent changes in adverse event (AE) rates, and herein apply it to a biologic drug. …”
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Physicochemical and in-vitro release studies of liponanocapsules by Tan, Dulcia Wei Ni.

“…The objective of this project is to optimize and study the formulation of stable polyelectrolyte coated liposomes called liponanocapsules. They are formed using the layer-by-layer (lbl) technique. …”
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G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Liao, C, Long, Y, Tsai, M, Lin, C, Hsu, K, Lee, C

“…Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. …”

Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The catalytic N- terminal domains (NTDs), the hydrolase and the synthetase, are called as the MtRel NTD. The purified catalytically active recombinant MtRel NTD was found to be a dimer in solution as determined by SAXS studies. …”
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That mysterious man by Lin, Enyi

“…Xu An is a rookie policeman who is working undercover in the Tang Nightclub as a waiter called Ann. The police suspect that the nightclub is implicated in the drug trade and Zhang Xu, a medicine dealer who is a regular, is involved. …”
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Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Valsson, Í, Warren, MT, Deane, CM, Magarkar, A, Morris, GM, Biggin, PC

“…However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. Here, we address these issues by first introducing a novel attention-based graph neural network model called AEV-PLIG (atomic environment vector–protein ligand interaction graph). …”

Activated Metals to Generate Heat for Biomedical Applications by Remlova, Eva, Feig, Vivian Rachel, Kang, Ziliang, Patel, Ashka, Ballinger, Ian, Ginzburg, Anna, Kuosmanen, Johannes, Fabian, Niora, Ishida, Keiko, Jenkins, Joshua, Hayward, Alison, Traverso, Giovanni

“…We then demonstrated one application of this reaction: to thermally actuate a gastric resident device made from a shape-memory alloy called Nitinol. Finally, we highlight the advantages and future directions for leveraging this novel in situ heat generation method beyond the showcased example.…”
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Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…The disease is characterized by increasing of immature white blood cells called "blasts", and is estimated to account for about 3% of incident cases for all kind of cancer worldwide. …”
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Integrate Traditional Chinese Medicine (TCM) into cognitive behavioural therapy to treat postpartum depression in Chinese culture contexts. by Han, Shuyu.

“…Furthermore, women are expected to provide breastfeed after delivery. Taking drugs such as antidepressants will be strongly believed it’s harmful to child. …”
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