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Transdermal Drug Delivery
Published 2016“…As each drugs have different molecular properties, operation parameters are varied accordingly. …”
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Final Year Project (FYP) -
2
A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases
Published 2019“…On deployment, the device swells to co-apt with the ureteric wall and ensure drug availability to these tissues. …”
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Journal Article -
3
Investigating viral glycosylation pathways for drug and vaccine development
Published 2021“…</p> <p>The current COVID-19 pandemic has highlighted the urgent need for vaccines and antiviral drugs. The principal topic of my DPhil centres on addressing these needs for viral infection. …”
Thesis -
4
Layer-by-layer assembled micro and nano carriers for drug delivery applications
Published 2013“…In nano- or microparticulate drug delivery, both control of the drug release and interaction of the particles with the cellular environment are critical attributes. …”
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Thesis -
5
Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis
Published 2023“…Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”
Thesis -
6
A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence
Published 2018“…The first layer is needed for sustained release of drug while the second layer is required for close contact with urothelial wall. …”
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Thesis -
7
Characterization and evaluation of bilayer coating for enhanced localization and sustained drug delivery for fibrosis-induced ureteral stricture
Published 2016“…The usage of a bilayer coating, consisting of a hydrogel layer and a drug-loaded polymer layer, allows for direct contact with the ureter walls upon swelling and drug delivery through the urothelium. …”
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Final Year Project (FYP) -
8
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria
Published 2024“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Journal Article -
9
Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents
Published 2021“…In addition to the emergence of resistance to last resort drugs, bacteria escape antibiotics killing by forming complex biofilms. …”
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Journal Article -
10
Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst
Published 2022“…We demonstrate that the mode of action is due to increased inhibition of peptidoglycan cell wall biosynthesis. The findings in this study demonstrate that on-demand NIR-light activated bioorthogonal conjugation of Van to microbes is a viable alternative treatment in combating drug-resistant bacteria.…”
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Journal Article -
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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY)
Published 2024“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”
Thesis -
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo...
Published 2014“…In part II, my first project is the development of novel drug-loaded nanogels for pH sensitive drug release, which will be described in chapter 3. …”
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Thesis -
13
RES.10-001 Making Science and Engineering Pictures, Fall 2014
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Learning Object -
14
Utilizing food waste and thermoplastic starch (TPS) in 3D printed PLA formulations for sustainable and customizable controlled delivery systems
Published 2024“…With the addition of TPS, the drug release profile can be adjusted from 8 – 120 hours using different TPS ratios and different printed wall thicknesses. …”
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Thesis-Master by Research -
15
Development of red/near-infrared fluorescent molecules and macromolecules for biomedical applications
Published 2017“…The hydrophobic layer of side chain was used to physically entrap drugs for chemotherapy. To address the potential problem of drug leakage, we utilized amphiphilic random copolymers containing drug-modified units as side chain of conjugated polymers instead in Chapter 7. …”
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Thesis -
16
You Are the Placebo : Making Your Mind Matter /
Published 2014“…Is it possible to heal by thought alone—without drugs or surgery? The truth is that it happens more often than you might expect. …”
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software, multimedia -
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Methods for the Study of Galactofuranose in Mycobacteria
Published 2024“…Second, we leveraged the rapidly expanding set of biosynthetic probes of the mycobacterial cell wall to rapidly characterize intracellular distances between distinct layers of the cell wall in Mycobacterium tuberculosis model organisms Corynebacterium glutamicum and Mycobacterium smegmatis using fluorescence resonance energy transfer. …”
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Thesis -
18
Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells.
Published 2008“…This study has shown that ApoA-l secretion in intestinal cells is constitutive; however, the rate of apoA-l secretion is increased by as high as 5-times the constitutive secretion rate when the cells are exposed to anti-inflammatory drugs such as aspirin and paracetamol. In contrast, pro-inflammatory drugs such as lipopolysaccharides and endotoxin appeared to decrease intestinal secretion of apoA-1. …”
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Research Report -
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Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2
Published 2015“…The Generally Regarded as Safe (GRAS) status of LAB such as Lactococcus lactis coupled with non-recombinant strategy of in-trans surface display system, provide a safe platform for therapeutic drug and vaccine development. However, therapeutic proteins fused with cell-wall anchoring motif production are predominantly limited to prokaryotic expression system. …”
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Thesis -
20
Please, let me go /
Published 2017“…From the age of 14, Caitlin was completely controlled, repeatedly raped, provided with alcohol, given drugs, sold and passed on to new gangs over and over again. …”
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