Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. …”
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Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

“…Although the two-dose mRNA vaccination regime provides protection against SARS-CoV-2, older adults have been shown to exhibit poorer vaccination responses. …”
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Using dynamic assessment of writing to promote technology-enhanced learning in higher education (Abstract) [Conference paper] by Meletiadou, Eleni

“…Responding to students’ request for the use of digitally-enhanced formative assessment practices, this project used a dynamic assessment approach that has been developed within the Vygotskian sociocultural theory of learning. …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…Objective:b-cell dedifferentiation has been revealed as a pathological mechanism underlying pancreatic dysfunction in diabetes. …”
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Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

“…Immunocompromised individuals have been excluded from landmark studies of messenger RNA vaccinations for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). …”
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Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…In the past decade, cancer immunotherapy has been a promising therapeutic strategy for cancer treatment. …”
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Novel material composites for dielectric elastomer actuators by Ankit

“…Robots have been around us for quite some time now. Robots are machines capable of performing tasks on their own with high accuracy and precision and minimal supervision to reduce human effort. …”
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Visualization of engine design, simulation and optimization by Wang, Yan Chao

“…Most of our work are implemented in JavaScript and the source code of the proposed PolarViz and the orthogonal Voronoi treemap have been uploaded into the GitHub. The thesis ends with the conclusions of our works and a discussion of future work.…”
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Phase measurements based indoor visible light positioning systems by Zhang, Sheng

“…Applications of LEDs in indoor communications have been gradually investigated in the last two decades. …”
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Rotor angle stability-constrained dispatch and control of large-scale wind penetrated power system by Yuan, Heling

“…In current research, robust optimization has been demonstrated as an effective approach to deal with uncertainties and ensure the robustness. …”
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Dynamics in blue emitting metal halide perovskites for light emitting diodes by Karlsson, Max

“…Successful implementation in LEDs has been attributed to efficient carrier funneling from large bandgap (donor) regions to low bandgap regions (acceptors) resulting in improved luminescence yields due to trap state filling from the locally increased carrier density. …”
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Mechanically durable and damage resilient dielectric elastomer actuators by Tan, Matthew Wei Ming

“…While various soft actuators have been designed, dielectric elastomer actuators (DEAs) have become prominent due to their rapid response times, large actuation strains, and energy densities. …”
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Contact-free motion-robust vital signs monitoring by Zheng, Tianyue

“…Consequently, researchers have been pursuing contact-free alternatives to address these limitations. …”
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Innovation and firm survival: the role of timing, funding, and networks by Gao, Ming

“…While many studies have discussed how innovation influences firms’ survival, little has been done to explore how this relationship is shaped by other factors. …”
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Conflict-free urban air mobility planning with an airspace-resource-centric approach by Dai, Wei

“…The conventional air transport system has been operating for over a hundred years with great performances in both efficiency and safety, which raises high requirements for the future operations of UAM. …”
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Singlish与文化和国族认同： 以目的论分析网络视频 "Singapore Bootcamp" 和 "The Ah Bengs" 的 Singlish 翻译策略 = Singlish and national identity: a study on the Singlish translation of "Singapore Bootcamp" an... by 曹清雯 Cao, Qingwen

“…Translation of Singlish is a subject that has not been thoroughly researched. This paper intends to study the importance of translating Singlish and explore the possibility of it reflecting Singapore's culture and identity. …”
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Continuous health-based optimal operation and control for mission-critical power systems by Kumar, Logesh

“…In recent years’ lot of research has been conducted to detect the faults in the system, but very few and little work is reported on the mitigation and post fault scenario. …”
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Digital twin and AI enabled predictive maintenance in building industry by Hu, Wei

“…The effectiveness of PdM has also been hindered by the dependence on labelled datasets, which are expensive and time-consuming to generate. …”
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Leveraging linguistic knowledge to enhance low-resource NLP applications by Zhu, Zixiao

“…As a result, several training paradigms have been developed to enhance the downstream performance of PLMs, as outlined below. …”
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Solution based synthesis of Cu2ZnSnS4 nanoparticles and thin films for solar cell application by Li, Zhenggang

“…An encouraging power conversion efficiency of 8.4% has been achieved using vacuum deposition method. However, the vacuum deposition techniques are often associated with high energy input and thus impose a significant cost on the devices. …”
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