Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1 by Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin, Wong, Leo E.

“…The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. …”
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Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

“…We show that luteolin inhibits the replication of all four serotypes of dengue virus, but the selectivity of the inhibition was weak. …”
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Percutaneous Intratumoral Immunoadjuvant Gel Increases the Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer by Som, Avik, Rosenboom, Jan‐Georg, Wehrenberg‐Klee, Eric, Chandler, Alana, Ndakwah, Gabrielle, Chen, Eric, Suggs, Jack, Morimoto, Joshua, Kim, Jonathan, Mustafa, Abdul Rehman, Marcos‐Vidal, Asier, Fintelmann, Florian J., Basu, Arijit, Langer, Robert, Traverso, Giovanni, Mahmood, Umar

“…Its ability to significantly augment the abscopal rate of cryoablation is demonstrated in otherwise immunotherapy resistant metastatic tumors in two aggressive colorectal and breast cancer dual tumor models with an all or nothing response, responders generally demonstrating complete regression of bilateral tumors in 90‐day survival studies.…”
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White-light-responsive prussian blue nanophotonic particles for effective eradication of bacteria and improved healing of infected cutaneous wounds by Chakraborty, Nayanika, Jha, Diksha, Singh, Vijay Pal, Kumar, Pradeep, Verma, Navin Kumar, Gautam, Hemant Kumar, Roy, Indrajit

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SemFunSim : a new method for measuring disease similarity by integrating semantic and gene functional association by Cheng, Liang, Li, Jie, Ju, Peng, Peng, Jiajie, Wang, Yadong

“…This indicates that SemFunSim is an effective method for drug repositioning.…”
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Small but prospective: development of enzyme-responsive small molecule fluorescent probes for specific bacterial imaging by Yan, Evelias Hui Xin

“…Owing to the evolving pathogenicity of bacteria, whereby more drug-resistant bacteria has been emerging and bacteria developing their own defense mechanism, traditional antimicrobial approaches like antibiotics treatment have been clinically ineffective. …”
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Renal-clearable molecular probe for near-infrared fluorescence imaging and urinalysis of SARS-CoV-2 by Liew, Si Si, Zeng, Ziling, Cheng, Penghui, He, Shasha, Zhang, Chi, Pu, Kanyi

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Organic solvent-assisted control of hydrogel structures and properties by Zhou, Quan

“…Hydrogels are three-dimensional (3D) cross-linked polymeric networks containing a significant amount of water and have found their applications in various fields, including tissue engineering, drug delivery, etc. However, major limitations still exist for hydrogels, especially their mechanical weakness, which limits their use in load-bearing applications. …”
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Genomic insights into Vibrio cholerae O1 responsible for cholera epidemics in Tanzania between 1993 and 2017 by Hounmanou, Yaovi Mahuton Gildas, Leekitcharoenphon, Pimlapas, Kudirkiene, Egle, Mdegela, Robinson H., Hendriksen, Rene S., Olsen, John Elmerdahl, Dalsgaard, Anders

“…The genomes were further analyzed in a global context of 590 strains of the seventh cholera pandemic (7PET), as well as environmental isolates from Lake Victoria. All Tanzanian cholera outbreaks were caused by the 7PET lineage. …”
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Chitosan nanofibrous scaffold with graded and controlled release of ciprofloxacin and BMP-2 nanoparticles for the conception of bone regeneration by Zhang, Sihan, Zhao, Guanglei, Mahotra, Manish, Ma, Shiyuan, Li, Wenrui, Lee, Hiang Wee, Yu, Hong, Sampathkumar, Kaarunya, Xie, Denghui, Guo, Jinshan, Loo, Joachim Say Chye

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Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI by Mathiyazakan, Vikneswaran, Wong, Chui Fann, Harikishore, Amaravadhi, Pethe, Kevin, Grüber, Gerhard

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Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation by Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng

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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

“…The inexpensive and widely available drug paracetamol inhibits CFHb-induced lipid peroxidation via reduction of ferryl haem to the less toxic Fe3+ state, and has been shown to reduce oxidative damage and improve renal function in patients with sepsis complicated by haemolysis as well as in falciparum malaria. …”
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Metformin degradation with combined Ozone/UV/H2O2 process by Fujinami, Shoko Carissa

“…As our bodies are unable to fully metabolise all Metformin, a significant amount of Metformin is excreted unchanged into water bodies and studies have found that Metformin is an endocrine disruptor compound (EDC) which can interfere with reproduction system. …”
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The influence of additives on the delivery of paclitaxel from bioresorbable PLGA films by Huang, Charlotte Liwen.

“…The study of the influences of additives on the drug delivery characteristics from PLGA thin films as a coating on angioplasty balloons was reported in this thesis. …”
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Multi-Modal Protein Function Prediction using a Joint Embedding Space from Two Graph Neural Networks by Tysinger, Emma P.

“…There’s a growing need for precise and quick computational prediction methods, filling the gap between sequence discovery and functional understanding. …”
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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”