Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities by Ding, Feiqing, Leow, Min Li, Ma, Jimei, William, Ronny, Liao, Hongze, Liu, Xue-Wei

“…Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.…”
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Viral content: a theory of vaccine hesitancy based on information encountering in the greater Manila area, Philippines by Sacramento, Simon Philip R., Sipin, Ian Dominic P.

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Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum by Hu, Guang An

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Discovery of stabilized functional mutants of human aquaporin 1 by Soh, Miao Yi

“…Aquaporins (AQPs) are essential water channel proteins found in the cell membranes of all forms of life. In this project, a random mutagenesis library for human aquaporin 1 (hAQP1) is generated and screened for functional mutants. …”
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Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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Mitigating marine megafauna captures in fisheries by Arlidge, W

“…</p> <p>Throughout the fishery case study, I draw on established decision-making processes to better understand the conservation issue at hand and to develop an understanding of what is necessary to empirically calculate net outcomes in data-poor fishing systems using the proposed framework. …”

Compressible hollow microlasers in organoids for high-throughput and real-time mechanical screening by Fang, Guocheng, Ho, Beatrice Xuan, Xu, Hongmei, Gong, Chaoyang, Qiao, Zhen, Liao, Yikai, Zhu, Song, Lu, Hongxu, Nie, Ningyuan, Zhou, Tian, Kim, Munho, Huang, Changjin, Soh, Boon Seng, Chen, Yu-Cheng

“…Here, we introduce biocompatible and compressible hollow microlasers that realize all-optical assessment of cellular stress within organoids. …”
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Childhood bullying and mental health: understanding risk, resilience, and the role of anti-bullying interventions by Guzman Holst, C

“…The best approaches to study causal effects are natural experiments, longitudinal data, and randomised controlled trials of interventions. This thesis combines all these approaches to examine the relationship between bullying and mental health across different contexts.…”

Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells by Kong, Lei, Chia, Hui Ling, Guan, Jianguo, Pumera, Martin, Nur Farhanah Rosli

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Dearomatization of (hetero)arenes through photodriven interplay between polysulfide anions and formate by Tan, Eugene Yew Kun, Mat Lani, Amirah S, Sow, Wayne, Liu, Yuliang, Li, Haoyu, Chiba, Shunsuke

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Integrate Traditional Chinese Medicine (TCM) into cognitive behavioural therapy to treat postpartum depression in Chinese culture contexts. by Han, Shuyu.

“…As in Chinese cultures, it is believed that any kind of drug has certain degree of side effects. In the end, all different kinds of factors have lead to the fact that most women suffering from postpartum disorders or depression left unwell treated. …”
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Predicting rifampicin resistance in M. tuberculosis using machine learning informed by protein structural and chemical features by Lynch, C, Adlard, D, Fowler, P

“…We have trained a learning models with the aim of complementing genetics-based drug susceptibility testing.</p> <br> <p><strong>Methods:</strong> We built a Test+Train dataset comprising 219 susceptible mutations. …”

Sharing is caring? International Society for Pharmacoepidemiology review and recommendations for sharing programming code by Tazare, J, Wang, SV, Gini, R, Prieto Alhambra, D, Arlett, P, Morales Leaver, DR, Morton, C, Logie, J, Popovic, J, Donegan, K, Schneeweiss, S, Douglas, I, Schultze, A

“…<p><strong> Methods: </p></strong>We conducted a literature review identifying all studies published in Pharmacoepidemiology and Drug Safety (PDS) between 2017 and 2022. …”

Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Bhattacharjee, NV, Schumacher, AE, Aali, A, Almidani, O, Bandyopadhyay, S, Graham, SM, Lacey, BWH, Maude, RJ, Runghien, T, Rodriguez, JAB

“…<p><b>Funding</b></p> Bill & Melinda Gates Foundation.…”

Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Vollset, SE, Ababneh, HS, Abate, YH, Lacey, BWH, GBD 2021 Forecasting Collaborators

“…&lt;h4&gt;Funding&lt;/h4&gt;Bill &amp; Melinda Gates Foundation.…”

Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

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The Relationship between Linguistic Representations in Biological and Artificial Neural Networks by Kauf, Carina

“…This thesis work makes progress on all three questions by combining evidence from neuroimaging, behavioral research, and computational modeling. …”
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Engineering pressure retarded osmosis membrane bioreactor (PRO-MBR) for simultaneous water and energy recovery from municipal wastewater by Liu, Shuyue, Song, Weilong, Meng, Manli, Xie, Ming, She, Qianhong, Zhao, Pin, Wang, Xinhua

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Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling by Rohatgi, Rajat, Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Covey, Douglas F, Siebold, Christian, Ingham, Philip William

“…Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants.…”
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Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

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