Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-... by Schumacher, AE, Kyu, HH, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, RJ, Bennett, D, Browne, AJ, Dolecek, C, Dunachie, SJ, Newton, CRJ, Rodriguez, JAB

“…Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. <p><b>Findings</b></p> Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). …”

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…The screen selected accurately for all the tested known drugs acting on TS. We also identified TS inhibitors with novel chemistry and marketed drugs that were not previously known to target TS, including the DNA methyltransferase inhibitor decitabine. …”
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Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device by Shuddhodana, Wong, Kathy Pooi Wen, Judeh, Zaher

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Identification and antimicrobial susceptibility of enterococcal species isolated from cats exposed to different antibiotics by Mohd Amin, Nor Azimah

“…Two multi drug resistant (MDR) enterococci and two extensively drug resistant (XDR) enterococci were detected in this present study.…”
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MicroRNAs in tissue engineering & regenerative medicine by Chew, Sing Yian

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Financial planning application using MATLAB App Designer by Renganathan, Preethi

“…FinanceMLab simplifies usage by using dynamic calculators that draw on reputable government sources [1], [2]. This ensures precise and consolidated financial planning. …”
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Painting and animating with graphics strokes by Cheong, Ying Ying.

“…The application is break down into two modes – Drawing Mode and Animation Mode. In the Drawing Mode, the user can draw brushstrokes using mouse motion, edits brushstroke’s form by manipulating the Catmull-Rom spline’s control points, all through an interactive 2D graphical user interface. …”
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Synthesis of chiral sulfinate esters by asymmetric condensation by Zhang, Xin, Ang, Esther Cai Xia, Yang, Ziqi, Kee, Choon Wee, Tan, Choon-Hong

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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Osoti, V, Wamae, K, Ndwiga, L, Gichuki, PM, Okoyo, C, Kepha, S, Keitany, K, Kandie, R, Aricha, S, Kiplagat, R, Mwandawiro, C, Bejon, P, Snow, RW, Ochola-Oyier, LI

“…Background: To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. …”

Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. …”
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Doctor, Will You Pray for Me? : Medicine, Chaplains, and Healing the Whole Person / by Klitzman, Robert, author 655971

“…Healthcare chaplains have been filling the void, developing valuable approaches and insights. …”
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Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study by Hamill, V, Wong, S, Benselin, J, Krajden, M, Hayes, PC, Mutimer, D, Yu, A, Dillon, JF, Gelson, W, Velásquez García, HA, Yeung, A, Johnson, P, Barclay, ST, Alvarez, M, Toyoda, H, Agarwal, K, Fraser, A, Bartlett, S, Aldersley, M, Bathgate, A, Binka, M, Richardson, P, Morling, JR, Ryder, SD, Barnes, E

“…The leading causes of death were drug related mortality (n=383, 24%), liver failure (n=286, 18%), and liver cancer (n=250, 16%). …”

Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Feigin, VL, Abate, MD, Abate, YH, Bandyopadhyay, S, Bennett, DA, Lacey, B, Newton, CRJ

“…Effective, accessible, and affordable measures to improve stroke surveillance, prevention (with the emphasis on blood pressure, lifestyle, and environmental factors), acute care, and rehabilitation need to be urgently implemented across all countries to reduce stroke burden. <p><b>Funding</b></p> Bill & Melinda Gates Foundation.…”

Non-traditional security issues : securitisation of transnational crime in Asia by Laki, James

“…Transnational crime involving all forms of domestic crime that tranverse the international boundary with another one or more states have become a concern amongst all peoples of the Asia Pacific region. …”
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Beyond national identity : Kuo Pao Kun’s contemporary theatre and an open culture by Wee, C. J. Wan-Ling

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Imagining post-fossil tourism mobilities with Norwegian tourists by Hopkins, D, Landa-Mata, I, Kr Steen Jacobsen, J, Farstad, E, Higham, J

“…Sustainable mobility has become a catch-all term to describe forms, modes, policies and practices of mobility that are thought to have a lower environmental footprint and/or fewer social exclusions than the contemporary mobility system which is reliant on fossil fuels and private ownership. …”

Striking a gut-liver balance for the antidiabetic effects of metformin by Barroso, Emma, Montori-Grau, Marta, Wahli, Walter, Palomer, Xavier, Vázquez-Carrera, Manuel

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A P450BM3 toolkit For C-H activation synthesis by Ren, X

“…Successful applications include drug metabolism, drug fragment diversification, synthesis of flavour and fragrance compounds, steroid oxidation, late-stage functionalisation in total synthesis, and C–H amination. …”

Formal contracts mitigate social dilemmas in multi-agent reinforcement learning by Haupt, Andreas, Christoffersen, Phillip, Damani, Mehul, Hadfield-Menell, Dylan

“…First, we show that this augmentation makes all subgame-perfect equilibria of all Fully Observable Markov Games exhibit socially optimal behavior, given a sufficiently rich space of contracts. …”
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A study of shoppers' motives and profiles by Ang, Delphine Ling Ling, Seah, Beng Huey, Hee, Li Ling

“…The study also revealed that the draw factors for the two kinds of shopping centres differ. …”
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