Cortical regulation of sleep by Krone, LB

“…These experiments revealed unexpected effects of the chemogenetic actuators clozapine-N-oxide (CNO) and Compound 21 (Cmpd21) on sleep in wild type mice, which do not express designer receptors exclusively activated by designer drugs (DREADDs). Finally, I present extensive work on ‘cortical SNAP25-ablated’ (<em>Rbp4-Cre;Ai14;Snap25^fl/fl</em>) mice, which served as a model for chronic silencing of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells. …”