Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY) by Karadzas, M

“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”

Modeling the Impact of Electrolyte Flow on Heat Management in a Li-Ion Convection Cell by Gao, Weiran, Drake, Javit, Brushett, Fikile R

“…We show, through physics-based electrothermal modeling and dimensional analysis of a single, planar LIB cell, that electrolyte convection can simultaneously draw heat from the cell and suppress heat generation from entropy change, charge-transfer, and ohmic losses, and that the cell temperature rise can be effectively mitigated when heat removal matches or exceeds heat generation. …”
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Techniques for analysis and integration of histology data and agent-based modelling of T cell-tumour interactions by Stephens, R

“…Here we aim to ascertain whether using the PCF to analyse the imaging data can uncover further insights into the efficacy of the drug, as opposed to the current clinical practice of recording cell counts and visual inspection of CD8+ T cell infiltration in the tumour. …”

Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. by Yu, Kenneth.

“…This study has shown that ApoA-l secretion in intestinal cells is constitutive; however, the rate of apoA-l secretion is increased by as high as 5-times the constitutive secretion rate when the cells are exposed to anti-inflammatory drugs such as aspirin and paracetamol. …”
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Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells by Zhu, Pengcheng, Tong, Benny Meng Kiat, Wang, Runze, Chen, Jiapeng, Foo, Selin, Chong, Han Chung, Wang, Xiao Ling, Ang, Gim Yean, Chiba, Shunsuke, Tan, Nguan Soon

“…Although endoperoxide-containing compounds have long been suggested as anticancer drugs, few have been clinically employed due to their instability, complex synthesis procedure or low tumor cell selectivity. …”
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Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell by Asial, Ignacio, Cheng, Yue Xiang, Engman, Henrik, Dollhopf, Maria, Wu, Binghuang, Nordlund, Pär, Cornvik, Tobias

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Conformational antibody binding to a native, cell-free expressed GPCR in block copolymer membranes by De Hoog, Hans-Peter M., Lin JieRong, Esther M., Banerjee, Sourabh, Décaillot, Fabien M., Nallani, Madhavan

“…We here show the cell-free expression of a GPCR, CXCR4, and its direct embedding in diblock copolymer membranes. …”
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In vitro evaluation of oral contraceptives on long-tailed macaque (Macaca fascicularis) primary ovarian cells by Muhammed, Mikail, Tengku Azizan, Tengku Rinalfi Putra, Mohd Noor, Mohd Hezmee, Abu Hassim, Hasliza, Che'Amat, Azlan, Saleh, Annas Bin, Han, Mark Hiew Wen, Ab Latip, Mohd Qayyum

“…We determine the cell viability and cytotoxicity as well as the morphological changes of the drugs on long-tailed macaque ovarian cells using the MTT assay, Acridine orange/propidium iodide double staining method, morphological examination, and the 4, 6-diamidino-2-phenylindole (DAPI) staining method. …”
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Hydroxyapatite nanoparticles-cell interaction: new approaches to disclose the fate of membrane-bound and internalised nanoparticles by Bonany, Mar, Pérez-Berná, Ana Joaquina, Dučić, Tanja, Pereiro, Eva, Martin-Gómez, Helena, Mas-Moruno, Carlos, van Rijt, Sabine, Zhao, Zhitong, Espanol, Montserrat, Ginebra, Maria-Pau

“…Hydroxyapatite nanoparticles are popular tools in bone regeneration, but they have also been used for gene delivery and as anticancer drugs. Understanding their mechanism of action, particularly for the latter application, is crucial to predict their toxicity. …”
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From 2D to 3D: development of monolayer dopaminergic neuronal and midbrain organoid cultures for Parkinson's disease modeling and regenerative therapy by Yeap, Yee Jie, Tng, Teddy J. W., Lee, Mok Jung, Goh, Micaela, Lim, Kah-Leong

“…In this review, we provide an update on the molecular processes underpinning the development and differentiation of human pluripotent stem cells (PSCs) into midbrain DA neurons in both 2D and 3D cultures, as well as the latest advancements in using these cells for drug discovery and regenerative medicine. …”
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Investigating the content and function of stress-induced extracellular vesicles in colorectal cancer by Mason, J

“…Extracellular vesicles (EVs) are nanosized membrane-bound vesicles, which carry rich bioactive cargoes that are able to influence and reprogramme recipient cell behaviour. In CRC, EVs are known to be potent drivers of primary tumour growth and metastasis, and have also been shown to modulate response to treatment by promoting drug resistance. …”

Externally Tunable, Low Power Electrostatic Control of Cell Adhesion with Nanometric High‐k Dielectric Films by Leon, Victor J., Blanc, Baptiste, Sonnert, Sophia D., Varanasi, Kripa K.

“…High performance dielectrics, HfO<jats:sub>2</jats:sub> and SiO<jats:sub>2</jats:sub>, enables a change in the ζ polarity and magnitude over large, 100 mV, ranges by applying ≈1 V across the dielectrics with ≈1nW power draw. Freshwater Chlorella vulgaris and saltwater Nannochloropsis oculata, which have a negative ζ, are used as model cells. …”
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Understanding the survival mechanism of metastatic cancer cells in circulation will provide new perspectives on metastasis prevention and also shed new light on metastasis-derived drug resistance. …”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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Synthesis, Characterisation Of Stilbene–Arylcinnamide Hybrids And Cytotoxic Studies Against Lung Cancer Cell A549 by Mohd Zaki, Nurain Syazwani

“…Numerous anticancer drugs have been designed from natural products. Several compounds derived from nature such as alkaloid, flavonoid, cinnamic acid and stilbene, were reported to possess various biological properties primarily as an anticancer agent. …”
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Single cell hydrodynamic stretching and microsieve filtration reveal genetic, phenotypic and treatment-related links to cellular deformability by Li, Fenfang, Cima, Igor, Vo, Jess Honganh, Tan, Min-Han, Ohl, Claus-Dieter

“…We also find that the drug docetaxel leads to an increase in the size of A549 lung cancer cells. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Cellular imaging studies displayed that the peptide nanogels could self-deliver drugs into cells through endocytosis and therefore provided effective antitumor activities toward resistant tumor cells. …”
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Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy by Volpatti, Lisa R, Bochenek, Matthew A, Facklam, Amanda L, Burns, Delaney M, MacIsaac, Corina, Morgart, Alexander, Walters, Benjamin, Langer, Robert, Anderson, Daniel G

“…These data show the potential of these biodegradable carriers for controlled drug and cell delivery for the treatment of diabetes with limited material accumulation in the event of multiple doses.…”
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The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures by Nguyen, Luong T. H., Muktabar, Aristo, Tang, Jinkai, Wong, Yee Shan, Thaxton, Colby S., Venkatraman, Subbu Subramanian, Ng, Kee Woei

“…Therefore, the use of anti-inflammatory drugs could reduce the risk of major adverse cardiovascular events due to atherosclerosis. …”
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Mechanistic insights on protein aggregation and phase separation by Casablancas Antràs, V