Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro by Smarslik, Maren, Inal, Jameel

“…In this study, the cytotoxic effects of 5-FU and iCRT3 were investigated using the Caco-2 colon adenocarcinoma cell line, marking the first investigation of their combined effects. …”
Get full text

Content learning in Japanese and English medium instruction: comparing chemistry learning outcomes in Japanese higher education by Aizawa, I

“…<p>English Medium Instruction (EMI) is rapidly gaining momentum in line with internationalisation of higher education trends. …”

An analysis of contact stiffness and frictional receding contacts by Parel, KS

“…Then, a fundamental 2D frictional receding contact problem involving a homogeneous linear elastic infinite layer pressed by a line load onto a half-plane of the same material was analysed. …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. However, if a short course of biologics can rapidly suppress inflammation allowing treatment to be withdrawn and response maintained on methotrexate, this may be a cost-effective model for early use.…”

Implementing strategies to improve uptake of patient-reported outcome measures (PROMs) in gender-affirming care: a mixed-methods implementation study by Kamran, R, Jackman, L, Goodwin, C, Laws, A, Stepney, M, Harrison, C, Jain, A, Rodrigues, J

“…</p> <p><strong>Main outcome(s) and measure(s)</strong> Response rates were calculated at 2-week intervals, in line with the deployment of each implementation strategy. …”

Ultra-thin oxide films by Hu, X

“…Various sizes have been found, and sides of these equilateral triangles all show a double-line feature aligned along the 〈 1 ^ˉ<sub style="position: relative; left: -.4em;">1</sub> 0〉 directions of the Au(111) lattice. …”

Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The aim of this study was to evaluate the in vitro activities of ethanolic extract of Tinospora crispa (EETC) on protein kinases involved in the lytic cycle of T. gondii infection in Vero cell line. The EETC was obtained through the maceration of dried stem powder. …”
Get full text

Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…Therefore, this study focuses on metabolite profiling, in silico or pharmacoinformatic activity and mechanisms, as well as advanced validation on in vitro cell lines. Ten compounds identified in E. bulbosa bulb ethanolic extract (EBE) showed cancer receptor and radical inhibitory activity via network pharmacology and molecular docking simulation. …”
Get full text

Design, synthesis and activity studies of antifreeze peptide derived from type I shorthorn sculpin by Asmawi, Azren Aida

“…Furthermore, these peptides have been proved to be non-cytotoxic on 3T3 cell line with IC50 value >100 μg/mL and have a positive impact on ice crystal growth in ice cream mixes. …”
Get full text

Attitudinal Factors of Fishermen Trapped in the B40 Category: an Empirical Study by Mustafar, Mastora, Mat Yamin, Fadhilah, Mohamed Ismail, Risyawati, Mohd Nawi, Nur Syazwani, Abu Bakar, Siti Zakiah, Johari, Ayub

“…However, its importance is not in line with the well-being of key players in the fishing industry itself, especially Zone A fishermen who are mostly in the Bottom 40% (B40) of household income category. …”
Get full text

Removal of ammonia from rubber wastewater using rubber-sludge-based biochar to enhance biogas production by NurulEzza Fazlina, Abu, Noor Yahida, Yahya, Fatin Zafirah, Mansur, Nurmunira, Muhammad

“…The highest ammonia removal was 7.5 mg/l at an initial adsorbent loading dosage of 1.5 g of RSB for 30 min of mixing. Further, during the AD process, the highest biogas yield of 19.061 ml/g was achieved after 28 days at pH 8. …”
Get full text
Get full text

Development of an educational method to rethink and learn oncological brain surgery in an “a la carte” connectome-based perspective by Valdes, Pablo A., Ng, Sam, Bernstock, Joshua D., Duffau, Hugues

“…Conclusions Taking no more than 3–5 min per patient and irrespective of their resource settings, we believe that this method will enable junior surgeons to develop an intuition, and a robust 3-dimensional imagery of WMT by regularly applying it to their cases both before and after surgery to develop an “a la carte” connectome-based perspective to glioma surgery.…”
Get full text

Quantum Speed-ups for String Synchronizing Sets, Longest Common Substring, and \(k\) -mismatch Matching by Jin, Ce, Nogler, Jakob

“…Our result improves upon previous upper bounds $\tilde O(\min \{n/d^{1/2}, n^{2/3}\})$ (Le Gall and Seddighin ITCS 2022, Akmal and Jin SODA 2022), and answers an open question of Akmal and Jin. …”
Get full text

Lenzen’s Distributed Routing Generalized: A Full Characterization of Constant-Time Routability by Ghaffari, Mohsen, Wang, Brandon

Get full text

Towards Optimal Output-Sensitive Clique Listing or: Listing Cliques from Smaller Cliques by Dalirrooyfard, Mina, Mathialagan, Surya, Williams, Virginia Vassilevska, Xu, Yinzhan

Get full text

Electrostatic microfiltration (EM) enriches and recovers viable microorganisms at low-abundance in large-volume samples and enhances downstream detection by Liu, Yaoping, Raymond, Joshua J, Wu, Xiaolin, Chua, Patrina Wei Lin, Ling, Sharon Yan Han, Chan, Chia Ching, Chan, Cheryl, Loh, Joanne Xin Yi, Song, Melody Xing Yen, Ong, Matilda Yu Yan, Ho, Peiying, Mcbee, Megan E, Springs, Stacy L, Yu, Hanry, Han, Jongyoon

“…This study develops an efficient electrostatic microfiltration (EM)-based sample preparation technique capable of processing ultra-large-volume (≥500 mL) samples at high throughput (≥10 mL min−1). This approach achieves a significant enrichment (>8000×) of extremely-low-abundance pathogens (down to level of 0.02 CFU mL−1, i.e., 10 CFU in 500 mL). …”
Get full text

Cooperation and Fairness in Multi-Agent Reinforcement Learning by Aloor, Jasmine, Nayak, Siddharth Nagar, Dolan, Sydney, Balakrishnan, Hamsa

“…We find that by training agents using min-max fair distance goal assignments along with a reward term that incentivizes fairness as they move towards their goals, the agents (1) learn a fair assignment of goals and (2) achieve almost perfect goal coverage in navigation scenarios using only local observations. …”
Get full text

Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1 by Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin, Wong, Leo E.

Get full text
Get full text

Functional homogeneity and specificity of topological modules in human proteome by Kaalia, Rama, Rajapakse, Jagath Chandana

Get full text
Get full text
Get full text

The influence of Ti doping on morphology and photoelectrochemical properties of hematite grown from aqueous solution for water splitting by Zhao, Xin, Feng, Jianyong, Wang, Ning, Yao, Xin, Chen, Wei, Chen, Shi, Huang, Zhaohong, Chen, Zhong

Get full text
Get full text