In vitro and in silico investigation of TRPC3 mechanism and dynamics by Collingridge, J

“…This work provides computational evidence for the ability of TRPC3 to form a widely conserved, mechanistically important π-helix structural component in the pore-lining S6 helix. This has not previously been reported for TRPC3, and simulations presented here suggest a role for the π-helix in promoting a transition towards an open state of the channel. …”

Psoriatic Arthritis Priority Setting Partnership: patient and clinician informed considerations for future UK health service delivery by James, L, Hailey, L, Bundy, C, Burstow, H, Chandler, D, Cowper, R, Helliwell, P, Joannes, L, Kelly, A, Kennedy, B, Kinsella, S, McAteer, H, Mukherjee, S, Packham, J, Wise, E, Young, H, Dures, E, Coates, LC

“…Further analysis within the rheumatology service theme revealed additional sub-themes that emphasised integrating multidisciplinary services, improving access to advice lines and ensuring fair access to treatments.</p> <br> <p><strong>Conclusion:</strong> The five key themes provide valuable insights into the important areas of interest within health service delivery in the UK. …”

Nebular dominated galaxies: insights into the stellar initial mass function at high redshift by Cameron, AJ, Katz, H, Witten, C, Saxena, A, Laporte, N, Bunker, A

“…In contrast, modelling the spectrum as primarily nebular provides a good fit to both the continuum and emission lines, motivating scenarios in which (a) we are observing only nebular emission or (b) the ionizing source is powering extreme nebular emission that outshines the stellar emission. …”

Investigating the contribution of the unfolded protein response to prostate cancer bone metastasis by Kaya, Z

“…Using paired androgen refractory cancer of the prostate (ARCaP) cell lines ARCaPE and ARCaPM which differ in their epithelial (E) and mesenchymal (M) characteristics, I found that components of IRE1 and ATF6 ER stress pathways are higher in ARCaPE cells than in ARCaPM and decreased upon osteogenic differentiation of ARCaPM cells. …”

Engineering control of rhizobacteria for plant growth promotion by Green, PWL

“…The rhizopine system was used to demonstrate tight transcriptional control of the NifA master transcriptional regulator of <em>nif</em> genes for nitrogen fixation <em>in vitro</em>, thereby developing a rhizopine responsive diazotrophic strain which can be assayed for plant growth promotion on rhizopine producing barley lines. To test the feasibility of controlled synthetic symbiosis in a nodule environment, rhizopine control of nitrogen fixation was assayed in the model symbiotic rhizobium <em>S. meliloti</em>. …”

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…We also demonstrate that elevation of ROS can trigger over-activity of the ALT pathway in osteosarcoma and glioma cell lines, resulting in excessive DNA damage and cell death. …”

Physical properties of keropok (fried crisps) in relation to the amylopectin content of the starch flours by Mohamed, Suhaila, Abdullah, Norakiah, Muthu, Mangayar Karasi

“…Linear expansion, oil absorption and elasticity were positively correlated to the total amylopectin content in the whole flour (r2 = 0.99, 0.97 and 0.97 respectively). The best fitted lines for prediction of linear expansion, oil absorption and elasticity of the fried crisps were 21y ≦ 0.35x ‐ 162, y=0.15x‐ 74 and y=0.0008x‐0.41 respectively, where x is the amylopectin content of the whole flour. …”

Potential biological control agents of Geosmithia morbida restrict fungal pathogen growth via mycoparasitism and antibiosis by Onufrak, Aaron J., Gazis, Romina, Gwinn, Kimberly, Klingeman, William, Khodaei, Sima, Perez Oñate, Luis I., Finnell, Autumn, Givens, Spencer, Chen, Cristine, Holdridge, David R., Hadziabdic, Denita

“…Additionally, one metabolite-producing Trichoderma isolate, TN4-47, completely inhibited the growth of all three G. morbida isolates across all tested metabolite concentrations and had comparatively greater tolerance to juglone compared to other Trichoderma isolates. Future lines of research should focus on characterizing the active antagonistic compound present in the metabolite filtrates, determine the mode of action of the active component(s), and elucidate how abiotic and biotic factors may influence the growth, persistence, and antagonistic activity of candidate biological control agents in planta.…”
Get full text

HiTrip: Historical trajectory interpolation for trawlers via deep learning on multi-source data by Zhao, Zhongning, Chen, Jiaxuan, Shi, Yuqi, Hong, Feng, Jiang, Guiyuan, Huang, Haiguang, Zhao, Jinhua

“…One inherent challenge for precise interpolation is the stark contrast between trawler movement patterns during steaming, characterized by straight lines, and fishing, which often involves consecutive turns. …”
Get full text

Rectified and Salt Concentration Dependent Wetting of Hydrophobic Nanopores by Polster, Jake W, Aydin, Fikret, de Souza, J Pedro, Bazant, Martin Z, Pham, Tuan Anh, Siwy, Zuzanna S

“…Nanopores lined with hydrophobic groups function as switches for water and all dissolved species, such that transport is allowed only when applying a sufficiently high transmembrane pressure difference or voltage. …”
Get full text

Induction of neuronal phenotypes from NG2+ glial progenitors by inhibiting epidermal growth factor receptor in mouse spinal cord injury by Ju, Peijun, Zhang, Si, Yeap, Yeeshan, Feng, Zhiwei

“…In addition, the neuronal differentiation of glial progenitors induced by EGFR inhibitor was further confirmed with two different cell lines either in vitro or through ex vivo transplantation experiment. …”
Get full text
Get full text

DevOps for Databases : A practical guide to applying DevOps best practices to data-persistent technologies / by Jambor, David, author 656261

“…Database administrators are no longer the only experts; site reliability engineers (SREs) and DevOps engineers are database experts as well. This blurring of the lines has led to increased responsibilities, making members of high-performing DevOps teams responsible for end-to-end ownership. …”
Get full text
Get full text

Pollen geochronology from the Atlantic coast of the united states during the last 500 years by Christie, Margaret A., Bernhardt, Christopher E., Parnell, Andrew C., Shaw, Timothy Adam, Khan, Nicole S., Corbett, Dorbett Reide, García-Artola, Ane, Clear, Jennifer, Walker, Jennifer S., Donnelly, Jeffrey P., Hasse, Tobias R., Horton, Benjamin P.

Get full text

High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner by Correa, Yubexi, Del Giudice, Rita, Waldie, Sarah, Thépaut, Michel, Micciula, Samantha, Gerelli, Yuri, Moulin, Martine, Delaunay, Clara, Fieschi, Franck, Pichler, Harald, Haertlein, Michael, Forsyth, V. Trevor, Le Brun, Anton, Moir, Michael, Russell, Robert A., Darwish, Tamim, Brinck, Jonas, Wodaje, Tigist, Jansen, Martin, Martín, César, Roosen-Runge, Felix, Cárdenas, Marité

Get full text

Le cinéma d’Afrique noire contemporaine: une impossible décolonisation? by Fouhba, H

“…Afin de capter des financements auprès des bailleurs de fonds et autres mécènes culturels, ces cinéastes contemporains réalisent des films qui présentent l’Afrique comme ce continent n’ayant véritablement pas évolué du point de vue anthropologique. …”

Amil Dan Pentafsirannya Sebagai Asnaf Zakat Dalam Konteks Syariah Dan Realiti Semasa Di Malaysia by Abu Bakar, Marina, Md. Tahir, Raziah

Get full text

Machine learning-based approaches for large-scale temporal data analytics by Seyed Ali Majid Zonoozi

“…In many domains such as telecommunications, finance and sensor monitoring, large volumes of unlabeled temporal data are continuously generated in a sequential format, where the timestamps of the generated records are available. …”
Get full text
Get full text
Get full text

Process-structure-property optimisation of basalt fibre reinforced thermoplastic composites by Hoo, Ming Shun

“…The results showed that the optimal MFI at 11.60 g/10mins at 260oC. The mechanical properties recorded showed ultimate tensile strength (UTS) of 708 ± 26 MPa, flexural strength of 1012 ± 43 MPa and elastic modulus of 33.1 ± 1.8GPa. …”
Get full text

Combining laser frequency combs and iodine cell calibration techniques for Doppler detection of exoplanets by Cahoy, K., Fischer, D., Spronck, J., Demille, D.

“…We propose a fiber-fed high precision spectrograph design that combines the existing ~5000-6000 A Iodine calibration system with a high-precision Laser Frequency Comb (LFC) system from ~6000-7000 A that just meets the redward side of the Iodine lines. The scientific motivation for such a system includes: a 1000 A span in the red is currently achievable with LFC systems, combining the two calibration methods increases the wavelength range by a factor of two, and moving redward decreases the 'noise' from starspots. …”
Get full text

Sequence-Dependent & -Independent Effects of Intron-Mediated Enhancement (IME) by Kowal, Emma J. K.

“…In this study we report the design and execution of several massively parallel reporter assays (MPRAs), interrogating the effect of tens of thousands of synthetic and natural intron sequences on gene expression in the human HEK293T and HeLa cell lines. We observe that even with random internal sequence, most of these introns splice well and trigger IME. …”
Get full text
Get full text