Supporting insulin initiation in type 2 diabetes in primary care: results of the Stepping Up pragmatic cluster randomised controlled clinical trial by Furler, John, O’Neal, David, Speight, Jane, Manski-Nankervis, Jo-Anne, Gorelik, Alexandra, Holmes-Truscott, Elizabeth, Ginnivan, Louise, Young, Doris, Best, James, Patterson, Elizabeth, Liew, Danny, Segal, Leonie, May, Carl, Blackberry, Irene

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Impact of the HOPE intervention on mental health literacy, psychological well-being and stress levels amongst university undergraduates: a randomised controlled trial by Tay, Jing Ling, Goh, Yong Shian Shawn, Sim, Kang, Klainin-Yobas, Piyanee

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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

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Robotic assisted upper limb training post stroke : a randomized control trial using combinatory approach toward reducing workforce demands by Budhota, Aamani, Chua, Karen S. G., Hussain, Asif, Kager, Simone, Cherpin, Adèle, Contu, Sara, Vishwanath, Deshmukh, Kuah, Christopher W. K., Ng, Chwee Yin, Yam, Lester H. L., Loh, Yong Joo, Rajeswaran, Deshan Kumar, Xiang, Liming, Burdet, Etienne, Campolo, Domenico

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UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract by Stritt, Kevin, Roth, Beat, Masnada, Audrey, Hammann, Felix, Jacot, Damien, Domingos-Pereira, Sonia, Crettenand, François, Bohner, Perrine, Sommer, Isabelle, Bréat, Emilien, Sauser, Julien, Derré, Laurent, Haschke, Manuel, Collins, James J., McKinney, John

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Vertical distribution of heavy metals in seawater column during IBA construction in land reclamation – re-exploration of a large-scale field trial experiment by Yin, Ke, Chan, Wei-Ping, Dou, Xiaomin, Lisak, Grzegorz, Chang, Victor Wei-Chung

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Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT) : study protocol for an effectiveness-implementation hybrid ra... by Tan, Bryan Yijia, Pereira, Michelle Jessica, Yang, Su-Yin, Hunter, David J., Skou, Soren Thorgaard, Thumboo, Julian, Car, Josip

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Predicting cognitive scores from wearable-based digital physiological features using machine learning: data from a clinical trial in mild cognitive impairment by Rykov, Yuri G., Patterson, Michael D., Gangwar, Bikram A., Jabar, Syaheed B., Leonardo, Jacklyn, Ng, Kok Pin, Kandiah, Nagaendran

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Exposure therapy with personalized real-time arousal detection and feedback to alleviate social anxiety symptoms in an analogue adult sample : pilot proof-of-concept randomized con... by Lin, Bernice Xiangting, Lee, Tih-Shih, Cheung, Yin Bun, Ling, Joanna, Poon, Shi Hui, Lim, Leslie, Zhang, Hai Hong, Chin, Zheng Yang, Wang, Chuan Chu, Krishnan, Ranga, Guan, Cuntai

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Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

“…A comprehensive number of clinical trials on CCP efficacy have already been conducted. …”

Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3... by Poh, Xuan Ying, Lee, I. Russel, Lim, Clarissa, Teo, Jefanie, Rao, Suma, Chia, Po Ying, Ong, Sean W. X., Lee, Tau Hong, Lin, Ray J. H., Ng, Lisa F. P., Ren, Ee Chee, Lin, Raymond T. P., Wang, Lin-Fa, Renia, Laurent, Lye, David C., Young, Barnaby Edward

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The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Kasturiratne, Anuradhani, Khawaja, Khadija I., Ahmad, Sajjad, Siddiqui, Samreen, Shahzad, Khurram, Athauda, Lathika K., Jayawardena, Ranil, Mahmood, Sara, Muilwijk, Mirthe, Batool, Tayyaba, Burney, Saira, Glover, Matthew, Palaniswamy, Saranya, Bamunuarachchi, Vodathi, Panda, Manju, Madawanarachchi, Suren, Rai, Baldeesh, Sattar, Iqra, Silva, Wnurinham, Waghdhare, Swati, Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Gage, Heather M., van Valkengoed, Irene G. M., Valabhji, Jonathan, Frost, Gary S., Loh, Marie, Wickremasinghe, Ananda R., Kooner, Jaspal S., Katulanda, Prasad, Jha, Sujeet, Chambers, John C.

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Nurse-led reinforced education by mobile messenger improves the quality of bowel preparation of colonoscopy in a population-based colorectal cancer screening program: a randomized... by Lam, Thomas Y. T., Wu, Peter I., Tang, Raymond S. Y., Tse, Y. K., Lau, James Y. W., Wu, Justin C. Y., Sung, Joseph Jao Yiu

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First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

“…The results of three of these trials are available; one has been published as a full paper, the other two in abstract form only. …”

Are tai chi and qigong effective in the treatment of TBI? A systematic review protocol by Laskosky, Nicole Alexandra, Huston, Patricia, Lam, Wai Ching, Anderson, Charlotte, Zheng, Ya, Zhong, Linda Lidan

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A commentary on the popcorn effect by Ross, Wendy

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Interventions that prevent or reduce perinatal loneliness and its proximal determinants: a restricted scoping review by Naughton-Doe, R, Nowland, R, Tierney, S, Webber, M, Wittkowski, A

“…Further research is needed to scope the grey literature, review papers in the global south, appraise intervention effectiveness, and co-produce interventions, including for fathers, LGBTQ+ parents, and cultural and religious minorities.</p> <p><strong>Trial registration</strong> The protocol for the trial was registered on Figshare.…”

Interventions that prevent or reduce perinatal loneliness and its proximal determinants: a restricted scoping review by Naughton-Doe, R, Nowland, R, Tierney, S, Webber, M, Wittkowski, A

“…Further research is needed to scope the grey literature, review papers in the global south, appraise intervention effectiveness, and co-produce interventions, including for fathers, LGBTQ+ parents, and cultural and religious minorities. Trial registration: The protocol for the trial was registered on Figshare.…”

Efficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis by Chow, R, Basu, A, Kaur, J, Hui, D, Im, J, Prsic, E, Boldt, G, Lock, M, Eng, L, Ng, TL, Zimmermann, C, Scotte, F

“…Although THC:CBD showed promised in a recent trial, further trials should examine its safety and efficacy in the context of regimens containing olanzapine.…”

Endoscopic third ventriculostomy (ETV) for idiopathic normal pressure hydrocephalus (iNPH) by Tudor, Katarina Ivana, Tudor, Mario, McCleery, Jenny, Car, Josip

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