A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Anti-mitotic drugs are the most-commonly utilised class of chemotherapeutic agents that are administered as first-line therapy; however, their clinical success has been impeded by chemoresistance and disease relapse. …”
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Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

“…We did not detect resistance mutations to new oral drugs, including bedaquiline and pretomanid. The current GeneXpert MTB/RIF system needs to be modified by using the newly launched Xpert MTB/XDR cartridge or line-probe assay. …”
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Rationalisation of antifungal properties of α-helical pore-forming peptide, mastoparan B by Lim, Edward Jianyang, Goh, Eunice Tze Leng, Tram, Nhan Dai Thien, Periayah, Mercy Halleluyah, Ee, Rachel Pui Lai, Barkham, Timothy Mark Sebastian, Poh, Zhi Sheng, Verma, Navin Kumar, Lakshminarayanan, Rajamani

“…Host defense peptides are regarded as the first line of defense against microbial invasion in both vertebrates and invertebrates. …”
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Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye by Fan, Yanliang, Zheng, Xiaofeng, Berggren, Per-Olof, Loo, Joachim Say Chye, Yusuf Ali

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Early detection of reduced artemisinin susceptibility in plasmodium falciparum using novel phenotypic indicators by Xiong, Aoli

“…Artemisinin-based combination therapies (ACT), the first-line anti-malarial treatments recommended by World Health Organization (WHO), have achieved great success globally since their introduction. …”
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Surface modification of smooth poly (L-lactic acid) films for gelatin immobilization by Li, Hai, Xia, Yun, Wu, Jumiati, He, Qiyuan, Zhou, Xiaozhu, Lu, Gang, Shang, Lei, Boey, Freddy Yin Chiang, Venkatraman, Subbu S., Zhang, Hua

“…Poly(l-lactic acid) (PLLA) is widely used in drug delivery and medical implants. Surface modification of PLLA with functional groups to immobilize gelatin or other extracellular matrix proteins is commonly used to improve its cellular affinity. …”
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Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…In conclusion, we present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.…”
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Emergence of spatio-temporal variations in chemotherapeutic drug efficacy : in-vitro and in-silico 3D tumour spheroid studies by Sheraton, Muniraj Vivek, Chiew, Geraldine Giap Ying, Melnikov, Valentin, Tan, E. Y., Luo, K. Q., Verma, N., Sloot, Peter M. A.

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Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response by Zhu, Lei, van der Pluijm, Rob W., Kucharski, Michal, Nayak, Sourav, Tripathi, Jaishree, White, Nicholas J., Day, Nicholas P. J., Faiz, Abul, Phyo, Aung Pyae, Amaratunga, Chanaki, Lek, Dysoley, Ashley, Elizabeth A., Nosten, François, Smithuis, Frank, Ginsburg, Hagai, von Seidlein, Lorenz, Lin, Khin, Imwong, Mallika, Chotivanich, Kesinee, Mayxay, Mayfong, Dhorda, Mehul, Nguyen, Hoang Chau, Nguyen, Thuy Nhien Thanh, Miotto, Olivo, Newton, Paul N., Jittamala, Podjanee, Tripura, Rupam, Pukrittayakamee, Sasithon, Peto, Thomas J., Hien, Tran Tinh, Dondorp, Arjen M., Bozdech, Zbynek

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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The test compound, sunitinib, was stable in all conditions studied and analyte extraction and detection sensitivity could be improved with sufficient off-line or on-line pre-moistening of the dried spot prior to PS-MS analysis after longer storage period. …”
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Janus particle preparation through UV-induced partial photodegradation of spin-coated particle films by Tan, Jasmine Si Jia, Wong, Chong Hui, Chen, Zhong

“…Photocatalytic titanium dioxide particles prefunctionalized with a surface coating were assembled as particle films via spin-coating on a substrate. The particle films were placed directly under an ultraviolet light source, which induced the photodegradation of the surface coating only on the particle surfaces exposed to the light. …”
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Enabling high performance n-type metal oxide semiconductors at low temperatures for thin film transistors by Tiwari, Nidhi, Nirmal, Amoolya, Kulkarni, Mohit Rameshchandra, John, Rohit Abraham, Mathews, Nripan

“…Amorphous oxide semiconductors have drawn considerable attention as a replacement for ubiquitous silicon based technologies. …”
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Effects of woven fabric embedment on thin film composite membranes for osmotically driven membrane processes (ODMPs) by Teo, Shino Yu Qin

“…Osmotically driven membrane processes (ODMPs) have drawn a lot of attention in recent years due to their potential applications in water purification, desalination and energy generation. …”
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Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…This study showed that EETC contains promising drug candidates effective against T. gondii that can target the protein kinase genes involved in the lytic cycle of the parasite to prevent disease progression.…”
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Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY) by Karadzas, M

“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”

Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…In part II, my first project is the development of novel drug-loaded nanogels for pH sensitive drug release, which will be described in chapter 3. …”
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Loopholes. by Li, Yvonne Meini., Law, Georgina Wan Yi., Phua, Geraldine Soo Yee.

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RES.10-001 Making Science and Engineering Pictures, Fall 2014 by Frankel, Felice C.

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