Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system by Upputuri, Paul Kumar, Pramanik, Manojit

“…The system takes advantage of an 803 nm pulsed laser diode having high repetition rate ~7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 seconds cross-sectional imaging. Cortical vasculature is imaged in scan-time of 5 seconds with high signal-to-noise ratio ~48. …”
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Neutron emission studies from miniature and medium size plasma focus device by Singh, Rajdeep Raweet.

“…Although dense plasma focus devices have attracted the attention of scientific community since 1960’s as a copious source of fusion neutrons but in the recent years owing to spin-off in the applications of compact and portable table top neutron sources in wider domain, like noninvasive interrogation of explosives and narcotic drugs (by using Pulsed Fast/Thermal Neutron Analysis (PFTNA) technique), dark matter research, radioisotope production, medical neutron therapy and soil humidity measurements, there has been renewed interest across the globe for the development of sub-kilojoule range, low energy small plasma focus device (hereafter called ‘Miniature Plasma Focus i.e. …”
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Rationale and concerns for using JAK inhibitors in axial spondyloarthritis by Ahmed, S, Yesudian, R, Ubaide, H, Coates, LC

“…Treatment options have advanced over recent years and have become more targeted, including biologic treatments and, more recently, small molecule oral drugs called Janus kinase inhibitors. These newer agents have a rapid onset of action, can be taken orally and have efficacy in reducing inflammation across the whole spectrum of disease. …”

Glucokinase activity in diabetes: too much of a good thing? by Ashcroft, FM, Lloyd, M, Haythorne, EA

QuickFit: A High-Throughput RT-qPCR-Based Assay to Quantify Viral Growth and Fitness In Vitro by Galvez, Nicolas M. S., Sheehan, Maegan L., Lin, Allen Z., Cao, Yi, Lam, Evan C., Jackson, Abigail M., Balazs, Alejandro B.

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Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. …”
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Arabic botany and pharmacology with particular reference to the work of Al-Zahrawi and Ibn Juljul in Muslim Spain by Johnstone, PC

“…They were moreover interested in local indigenous plant names - in the language which they called Latīnī or ^cajamiyat al-Andalus.</p>…”

Structural study of enteroviruses by Qin, L

“…Although they have been studied for decades, few vaccines or drugs are in use. Indeed, many structural details of enterovirus infection, immune response and life cycle remain unknown. …”

Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives by Rabadà, Yvette, Bosch-Sanz, Oriol, Biarnés, Xevi, Pedreño, Javier, Caveda, Luis, Sánchez-García, David, Martorell, Jordi, Balcells, Mercedes

“…A new family of antifibrinolytic drugs has been recently discovered, combining a triazole moiety, an oxadiazolone, and a terminal amine. …”
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Low-power processors for implantable epileptic seizure detection system by Baihaqi, Muhammad Rayhan

“…Despite several treatments are available to suppress the seizure such as anti-epileptic drugs and surgery, around 25% of the epileptic patients still experiences the seizure. …”
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Views and factors influencing Primary Care Practitioner (pcp) interactions with the pharmaceutical industrys representatives in Malaysia: a multi-sectors qualitative study by Salim, Hani, Ping, Yein Lee, Siew, Mooi Ching, Mawardi, Maliza, Wan Idris, Wan Noor Azlin, Harrun, Noor Harzana

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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…Although numerous study has been done on plants to discover new drugs for the treatment of chronic diseases like cancer, the products of the mango plant species Mangifera indica L. waterlily, particularly the kernel have not adequately investigated. …”
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Cortical regulation of sleep by Krone, LB

“…These experiments revealed unexpected effects of the chemogenetic actuators clozapine-N-oxide (CNO) and Compound 21 (Cmpd21) on sleep in wild type mice, which do not express designer receptors exclusively activated by designer drugs (DREADDs). Finally, I present extensive work on ‘cortical SNAP25-ablated’ (<em>Rbp4-Cre;Ai14;Snap25^fl/fl</em>) mice, which served as a model for chronic silencing of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells. …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. …”

Synthesis, Characterisation Of Stilbene–Arylcinnamide Hybrids And Cytotoxic Studies Against Lung Cancer Cell A549 by Mohd Zaki, Nurain Syazwani

“…The cytotoxicity against human lung cancer A549 cell line was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, using cisplatin as the positive control. …”
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Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket by Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra

“…Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and rapidly result in the emergence of resistance. …”
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Teaching and learning guide on the ethics of human enhancement by Giubilini, A

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex by Diao, X, Shang, Q, Guo, M, Huang, Y, Zhang, M, Chen, X, Liang, Y, Sun, X, Zhou, F, Zhuang, J, Liu, S, Vogel, CFA, Rastinejad, F, Wu, D

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay

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Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr by Zhang, Yingdan, Chew, Alvin Bing Liang, Wang, Jing, Yuan, Mingjun, Yam, Joey Kuok Hoong, Luo, Dahai, Yang, Liang

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