A preliminary investigation into the use of cannabis suppositories and online mindful compassion for improving sexual function among women following gynaecological cancer treatment by Banbury, Sam, Tharmalingam, Hannah, Lusher, Joanne, Erridge, Simon, Chandler, Chris

“…Eighty-three participants aged between 18 and 50+ years who were at least six months post-cancer treatment were randomly allocated to one of four groups, depending on whether they were already using cannabis suppositories. …”
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Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood by Rammos, A, Sullivan, SA, Kounali, D, Jones, HJ, Hammerton, G, Hines, LA, Lewis, G, Jones, PB, Cannon, M, Thompson, A, Wolke, D, Heron, J, Zammit, S

“…</p> <br> <p><strong>Method:</strong> Using data from 8045 individuals from a birth cohort study, longitudinal profiles of psychotic experiences based on semi-structured interviews conducted at 12, 18 and 24 years were defined. Environmental, cognitive, psychopathological and genetic determinants of these profiles were investigated, along with concurrent changes in psychopathology and cognition.…”

West African labour and the development of mechanised mining in southwest Ghana, c.1870s to 1910 by Mark-Thiesen, C

“…Divided into three sections, this thesis examines the practice of indirect labour recruitment for the mines during the formative years of colonial rule; the incorporation of ‘traditional’ credit relationships into ‘modern’ commerce. …”

Markers of synovial inflammation in cohorts at risk of knee osteoarthritis by Kluzek, S

“…Data from two cohorts has been utilised for the purpose of this thesis: the Oxford Knee Injury Cohort, a prospective study of NHS patients with recent ACL and/or meniscal injuries, and the Chingford women’s study, a community-based prospective cohort with over 23 years of follow-up. </p> <p><b>Results.</b> Cross-sectionally, sonographic markers correspond well with microscopically defined post-traumatic synovitis. …”

Cohort differences in physical health and disability in the United States and Europe by Gimeno, L, Goisis, A, Dowd, JB, Ploubidis, GB

“…<p><strong> Methods</strong></p> Using data from nationally representative studies of adults aged ≥50 years from the United States (Health and Retirement Study, n = 26,939), England (English Longitudinal Study of Ageing, n = 14,992) and 11 continental European countries (Survey of Health, Ageing and Retirement in Europe, n = 72,595), we estimated differences in the age-adjusted prevalence of self-reported chronic disease and disability and observer-measured health indicators across pseudo-birth cohorts (born &lt;1925, 1925–1935, 1936–1945, 1946–1954, 1955–1959). …”

The Pandemic EVIDENCE Collaboration Pillar 1: diagnostics and transmission by Conly, J, Plüddemann, A, Jefferson, T, Rosca, C, Heneghan, C

“…Despite the learnings from the recent pandemic, significant gaps remain in our understanding of the diagnosis of acute respiratory viral infections and their sequelae, the modes of transmission, and how to effectively synthesise the existing evidence from the past 70 years of research on respiratory viruses. It is crucial to examine further the evidence on how common respiratory viral agents are transmitted. …”

Depressive symptoms in adolescence and adult educational and employment outcomes: a structured life course analysis by López-López, JA, Tilling, K, Pearson, RM, Fazel, MS, Washbrook, E, Zhu, Y, Smith, BJ, Dunn, EC, Smith, ADAC

“…</p> <br> <p><strong>Results:</strong> Our analysis sample included participants with full information on NEET status (N = 3951), and the results supported the accumulation of risk model, showing that the odds of NEET increase by 1.015 (95% CI 1.012–1.019) for an increase of 1 unit in depression at any age between 11 and 24 years.</p> <br> <p><strong>Conclusions:</strong> Given the adverse implications of NEET status, our results emphasize the importance of supporting mental health during adolescence and early adulthood, as well as considering specific needs of young people with re-occurring depressed mood.…”

The association between the proportion of Brexiters and COVID-19 death rates in England by Phalippou, L, Wu, B

“…</p> <p><strong>Objective:</strong> Ecological study of whether there exists a significant conditional correlation between two variables that appear unrelated except for attitude towards experts: i) Proportion of people voting in favor of remaining in the European Union in 2016 and ii) COVID-19 outcomes four years later: death rates, vaccination rates. A significant conditional correlation would indicate that polarized beliefs have important consequences across a broad spectrum of societal challenges. …”

The Pandemic EVIDENCE Collaboration Pillar 2: interventions and evidence by Fretheim, A, Onakpoya, I, Bartoszko, J, Jones, M, Gandini, S

“…Pilot and feasibility studies are needed to determine how we may best develop evidence for NPIs for viral respiratory pathogens in seasonal endemic and epidemic settings and how this evidence should be optimally applied in the intervening years to reduce uncertainties during future pandemics.…”

Genetic, natal, and spatial drivers of social phenotypes in wild great tits by Satarkar, D, Sepil, I, Sheldon, BC

“…Centrality showed heritability up to 10% in one of 3&thinsp;years sampled, whereas betweenness showed none, indicating modest genetic variation in individual sociability, but not group-switching tendencies. …”

Use of intravenous immunoglobulin for the treatment of autoimmune encephalitis: audit of the NHS experience by Kinsella, JA, Irani, SR, Hollingsworth, R, O’Shaughnessy, D, Kane, P, Foster, M, Schott, JM, Lunn, MP

“…</p> <p><strong>Results</strong> A total of 625 patients who were 18 years of age or older were treated with intravenous immunoglobulin for autoimmune encephalitis, of whom 398 were determined as having 'highly likely' or 'definite' autoimmune/limbic encephalitis. …”

Diagnostic accuracy of point-of-care lung ultrasound for community-acquired pneumonia in children in ambulatory settings: a systematic review and meta-analysis by Hughes-Davies, H, Ukwatte, U, Roberts, N, Turner, PJ, Hayward, GN, Fanshawe, TR, Bird, C

“…<p><strong>Introduction:&nbsp;</strong>To perform a systematic review of the diagnostic accuracy of point-of-care lung ultrasound, compared to chest radiography, in children and young people (0&ndash;21 years) who present to ambulatory settings with suspected community-acquired pneumonia.…”

The role of circulating tumor DNA in melanomas of the uveal tract by Zameer, MZ, Jou, E, Middleton, M

“…Accordingly, although current treatments have an excellent local disease control rate, approximately 50% of patients develop metastatic relapse within 10 years. The high risk for metastatic disease with a variable and often long latency period is thought to be due to early spread of cancer cells disseminating into organs such as the liver, followed by a period of dormancy, before the eventual emergence of radiologically measurable disease. …”

Burden of diseases attributable to excess body weight in 204 countries and territories, 1990–2019 by Safiri, S, Grieger, JA, Ghaffari Jolfayi, A, Mousavi, SE, Nejadghaderi, SA, Fazlollahi, A, Sullman, MJM, Karamzad, N, Sahin, F, Singh, K, Collins, GS, Kolahi, A

“…For adults, EBW was defined as a body mass index (BMI) exceeding 25 kg/m2, while for children aged 1 to 19 years, EBW was determined according to the standards set by the International Obesity Taskforce. …”

Maternal postpartum six-week check and short-term health outcomes for women with hypertensive disorders in pregnancy: an observational study using the Clinical Practice Research Da... by Ramakrishnan, R, Korb, D, Li, Y, Knight, M, Carson, C

“…</p> <br> <p><strong>Methods:</strong> Data were from the UK Clinical Practice Research Datalink GOLD for women aged 15-49 years at childbirth in 2000–2018, who were diagnosed with HDP, and were registered for &gt;12 months postpartum. …”

Characterisation of the genomes of brain metastases by Ulahannan, D

“…Interventions include surgery and stereotactic radiosurgery with few metastases, with whole brain radiotherapy serving a role in patients with several metastases. In recent years, there have been increased efforts directed towards early phase trials to address the role of targeted biological agents towards pathogenic drivers namely, <em><b>EGFR, HER2</b></em> and <em><b>BRAF</b></em>. …”

Development of a brief assessment tool to identify children with probable anxiety disorders by Reardon, T, Ukoumunne, OC, Ball, S, Gray, A, Violato, M, iCATS Team, Creswell, C

“…</p> <p><strong>Methods</strong></p> <p>Children (aged 8–11 years), and their parents/carers and teachers from 19 primary/junior schools in England each completed a pool of questionnaire items that assessed child anxiety symptoms and associated impact. …”

The junior officers of the Roman army, 91BC - AD14 by Wrobel, T

“…The reforms of Augustus that followed, and the junior officer corps of the earliest years of the Principate are also discussed, in particular the notable military innovations of the Augustan period and the role of the Italian and provincial equestrian ordo. …”

RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Lentzen, M, Vairavan, S, Muurling, M, Alepopoulos, V, Atreya, A, Boada, M, de Boer, C, Conde, P, Curcic, J, Frisoni, G, Galluzzi, S, Gjestsen, MT, Gkioka, M, Grammatikopoulou, M, Hausner, L, Hinds, C, Lazarou, I, de Mendonça, A, Nikolopoulos, S, Religa, D, Scebba, G, Jelle Visser, P, Wittenberg, G, Narayan, V

“…Our approach involved a univariate analysis using Analysis of Covariance (ANCOVA) to analyze individual features of six RMTs while adjusting for variables such as age, sex, years of education, clinical site, BMI and season. …”

Extreme rainfall and landslides as a response to human-induced climate change: a case study at Baixada Santista, Brazil, 2020 by Couto de Souza, D, Crespo, NM, Vieira da Silva, D, Harada, LM, Parrode de Godoy, RM, Domingues, LM, Luiz, R, Bortolozo, CA, Metodiev, D, Magalhaes de Andrade, MR, Hartley, A, Cesario de Abreu, R, Li, S, Lott, F, Sparrow, S

“…Changes in land cover and urbanization showed a pronounced increase in urbanized area in Guarujá (107%), São Vicente (61.7%) and Santos (36.9%) and a reduction in farming area. In recent years, the region has experienced an increase in population growth and a rise in the proportion of irregular and/or precarious housing in high-risk areas. …”