Mechanistic insights into the HPF1/PARP1 complex by Zobel, FFH

“…While PARP1 was originally described to modify target substrates on glutamate and aspartate sites, it has become apparent in recent years that the presence of another protein, histone PARylation factor 1 (HPF1), switches its preference to serine target sites. …”

HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…This association was further reflected in an increasingly later age of onset across each genotype group, with a delay of up to 11 years, while HLA-DQ-dosage dependent effects were also suggested by reduced risk in the presence of non-predisposing DQ1 alleles. …”

Prussian Blue analogue materials for magnetic and energy storage applications by Schart, M

“…Upon its discovery in the 18th century, Prussian Blue, the first synthetic pigment, gained fame for its intense colour. Over the years since, many multifunctional properties have been discovered in its analogue materials. …”

Self-supervised machine learning to characterise step counts from wrist-worn accelerometers in the UK Biobank by Small, SR, Chan, S, Walmsley, R, von Fritsch, L, Acquah, A, Mertes, G, Feakins, BG, Creagh, A, Strange, A, Matthews, CE, Clifton, DA, Price, AJ, Khalid, S, Bennett, D, Doherty, A

“…Our data indicate an inverse dose-response association, where taking 6,430-8,277 daily steps was associated with 37% [25-48%] and 28% [20-35%] lower risk of fatal CVD and all-cause mortality up to seven years later, compared to those taking fewer steps each day.…”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Results: Among the participants (mean age 38.0 years, predominantly Black), the prevalence of hypertension was 25.7% (210 out of 818 participants). …”

Frailty, multimorbidity and polypharmacy: exploratory analyses of the effects of empagliflozin from the EMPA-KIDNEY trial by Mayne, KM, Sardell, R, Staplin, N, Judge, P, Zhu, D, Sammons, E, Wanner, C, Emberson, J, Preiss, D, Landray, M, Baigent, C, Haynes, R, Herrington, W

“…</p> <br> <p><strong>Methods:</strong> The EMPA-KIDNEY trial randomized 6609 patients with CKD (estimated glomerular filtration rate [eGFR] ≥20<45 mL/min/1.73m2 , or ≥45<90 mL/min/1.73m2 with urinary albumin-to-creatinine ratio ≥200 mg/g) to receive either empagliflozin 10 mg daily or matching placebo and followed for two years (median). Additional characteristics analysed in subgroups were multimorbidity, polypharmacy and health-related quality of life (HRQoL) at baseline. …”

The geomorphic work of the European mole (Talpa europaea): long-term monitoring of molehills using structure-from-motion photogrammetry by Baxter, T, Woor, S, Coombes, M, Viles, H

“…</em><em>europaea</em> over larger spatial scales (e.g. river catchments) and longer timescales (e.g. years‒decades) to determine its importance in relation to other bioturbators and within the wider sediment system.…”

The mediating role of health literacy between the presence of chronic disease and psychological distress among older persons in Xian City of China by Guo, Kun, Ouyang, Jing, Minhat, Halimatus Sakdiah

“…Methods: This study employs a quantitative research design using a cross-sectional survey of 300 older persons over 60 years living in the six urban districts of Xi’an city. …”
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Machine Learning Approaches for the Prediction of Postoperative Major Complications in Patients Undergoing Surgery for Bowel Obstruction by Mazzotta, Alessandro D., Burti, Elisa, Causio, Francesco Andrea, Orlandi, Alex, Martinelli, Silvia, Longaroni, Mattia, Pinciroli, Tiziana, Debs, Tarek, Costa, Gianluca, Miccini, Michelangelo, Aurello, Paolo, Petrucciani, Niccolò

“…Conventional assessment methods for outcomes in bowel obstruction cases often concentrate on isolated factors, and the evaluation of results for individuals with bowel obstruction remains poorly studied. …”
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Stratosphere - troposphere interaction during stratospheric sudden warming events by Domeisen, Daniela I. V. (Daniela Iris Vera)

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Essays on multi-echelon inventory control by Wan, Guangyu

“…Numerical experiments show that myopic optimal allocation performs better than virtual allocation, particularly in cases with large number of retailers, high service level requirements, large demand rate, large difference between retailers, and short system replenishment cycle. …”
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Quantitative analysis of coronary artery from computed tomography angiography images by Cui, Hengfei

“…Since lumen shapes of the lesion are irregular, diameter assessment may distort the true extent of stenosis in many cases [10]. An automated, robust and efficient method to approach most Computed Tomography Angiography (CTA) images is still in demand due to the intrinsic ill-posedness and the external stenosis quantification difficulties such as manual measurement, low contrast and huge processing time, which motivates the studies in this thesis. …”
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Embedded computing techniques for remote mobile video surveillance systems by Nirmala Ramakrishnan

“…Evaluations on aerial video datasets show that for 95% of the frames, GME with the first pass sparse estimation is performed, while achieving a similar accuracy as the dense set of features for 97% of the cases. Results with simulated data show that the proposed method is able to deterministically ramp up the features when the number of moving objects is increased. …”
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Space charge induced beam loss on a high intensity proton synchrotron by Pine, B

“…Image resonances were found and described for a variety of simulation parameters starting with a smooth focusing lattice and uniform density beam, then progressing to more realistic cases including waterbag beams, alternating gradient lattices and conformal vacuum vessels. …”

Distribution and risk factors of canine heart diseases and survey for owners treatment intention by Noordin, Norhidayah

“…Heart disease accounts for up to 10.0% of canine cases reported in a primary veterinary healthcare centresoverseas. …”
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Study on OFDM in underwater wireless communications by Pravitha Gopikannan.

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Distributed consensus of second-order multi-agent systems by Yu, Zhong

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Mastering Voice Interfaces : Creating Great Voice Apps for Real Users / by Thymé-Gobbel, Ann, author 642940, Jankowski, Charles, author 642941

“…We start with the basics of voice interfaces, and how they are different from others, then dive into basic design principles that we're learned in many years building these apps in the industry. As we cover a design principle, we'll also demonstrate how to implement it with one of the established voice platforms (Google Home), and show how, though the tools are great, you don't have to go too far to have to do some custom work to get what you really want. …”

Behave The Biology of Humans at Our Best and Worst / by Sapolsky, Robert M., author 656050, Penguin Random House (Online service) 655978

“…And on and on, back to evolutionary factors millions of years old. The result is one of the most dazzling tours d'horizon of the science of human behavior ever attempted, a majestic synthesis that harvests cutting-edge research across a range of disciplines to provide a subtle and nuanced perspective on why we ultimately do the things we do...for good and for ill. …”
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Which surrogate insulin resistance indices best predict coronary artery disease? A machine learning approach by Mirjalili, Seyed Reza, Soltani, Sepideh, Meybodi, Zahra Heidari, Marques-Vidal, Pedro, Firouzabadi, Danial Dehghani, Eshraghi, Reza, Restrepo, David, Ghoshouni, Hamed, Sarebanhassanabadi, Mohammadtaghi

“…Methods We followed a cohort of 2,000 individuals, ranging in age from 20 to 74, for a duration of 9.9 years. We utilized multivariate Cox proportional hazard models to investigate the association between TyG-index, TyG-BMI, TyG-WC, TG/HDL, plus METS-IR and the occurrence of CAD. …”
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