Cardiocutaneous syndrome is caused by aggregation of iASPP mutants by Lotz, R, Osterburg, C, Schäfer, B, Lu, X, Dötsch, V

“…In contrast to these germline mutations causing cardiocutaneous syndromes, missense mutations found in cancer do not result in aggregation.…”

Electrochemical DNA-nano biosensor for the detection of cervical cancer-causing HPV-16 using ultrasmall Fe₃O₄-Au core-shell nanoparticles by Rasouli, Elisa, Basirun, Wan Jefrey, Johan, Mohd Rafie, Rezayi, Majid, Mahmoudian, Mohammad Reza, Poenar, Daniel Puiu

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Cause-Specific Excess Mortality During the COVID-19 Pandemic (2020–2021) in 12 Countries of the C-MOR Consortium by Beeks, Victoria V., Achilleos, Souzana, Quattrocchi, Annalisa, Pallari, Chryso T., Critselis, Elena, Salameh, Pascale, Rahmanian Haghighi, Mohammad R., Rodriguez-Llanes, Jose M., Ambrosio, Giuseppe, Artemiou, Andreas, Gabel, John, Bennett, Catherine M., Cuthbertson, Joseph, Zimmermann, Claudia

“…Methods We collected weekly cause-specific mortality data from respiratory disease, pneumonia, cardiovascular disease (CVD) and cancer from national vital statistic databases. …”
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Indirect effects of the COVID-19 pandemic: A cause-of-death analysis of life expectancy changes in 24 countries, 2015 to 2022 by Polizzi, A, Zhang, L, Timonin, S, Gupta, A, Dowd, JB, Leon, DA, Aburto, JM

“…Most countries saw small changes in suicide mortality during the pandemic, while alcohol mortality increased and cancer mortality continued to decline. Patterns for other causes were more variable. …”

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Glob... by Naghavi, M, Ong, KL, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, R, Dolecek, C, Lacey, BWH

“…The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model—a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates—with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. …”

A review of reporting quality in case-control studies of pancreatic cancer by MacCarthy, A, MacCarthy, A, Dhiman, P, Dhiman, P, Kirtley, S, Kirtley, S, Logullo, P, Logullo, P, Copsey, B, Copsey, B, Collins, G, Collins, G

“…Study title: A review of reporting quality in case-control studies of pancreatic cancer. The data in the Excel file (Scores reporting case-control studies.xlsx) for this study are the reporting quality scores for 47. published case-control studies investigating risk factors for pancreatic cancer published between 2016 and 2018. …”

The study of Rashomon effects on machine learning : a case study on breast cancer by Wee, Yu Hui

“…In this study, we will be using 3 ER breast cancer datasets as a case study and we look at the results of the selection of each individual tree in the forest using the standard random forest algorithms and when bootstrapping of the attributes was removed. …”
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Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Design: Two nested case-control studies. Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Early-onset breast cancer in a woman with a germline mobile element insertion resulting in BRCA2 disruption : a case report by Deuitch, Natalie, Li, Shao-Tzu, Courtney, Eliza, Shaw, Tarryn, Dent, Rebecca, Tan, Veronique, Yackowski, Lauren, Torene, Rebecca, Berkofsky-Fessler, Windy, Ngeow, Joanne

“…Mobile element insertions (MEIs) contribute to genomic diversity, but they can be responsible for human disease in some cases. Initial clinical testing (BRCA1, BRCA2 and PALB2) in a 40-year-old female with unilateral breast cancer did not detect any pathogenic variants. …”
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Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK by Papier, K, Bradbury, KE, Balkwill, A, Barnes, I, Smith-Byrne, K, Gunter, MJ, Berndt, SI, Le Marchand, L, Wu, AH, Peters, U, Beral, V, Key, TJ, Reeves, GK

“…Uncertainty remains regarding the role of diet in colorectal cancer development. We examined associations of 97 dietary factors with colorectal cancer risk in 542,778 Million Women Study participants (12,251 incident cases over 16.6 years), and conducted a targeted genetic analysis in the ColoRectal Transdisciplinary Study, Colon Cancer Family Registry, and Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). …”

Knowledge on gastric cancer, attitude on screening for gastric cancer and screening behavior of gastric cancer among out patients in Hospital Universiti Sains Malaysia by Saffai, Siti Norzietai

“…Gastric cancer is heterogenous or multifactorial disease which is it affects the human physical and psychosocial well-being and leading cause of morbidity, mortality, economic burden in both developed and developing countries. …”
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Targeted therapy to gastric cancer by Hou, Qian.

“…Gastric cancer is a leading cause of death in Asia and a heterogeneous disease. …”
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Functional genetics of cancer and congenital disorders by Zak, J

“…This thesis aims to identify and assess pathogenic mutations in the 1q41q42 microdeletion syndrome, neural tube defects, neuropsychiatric disorders and cancer. Rare microdeletions at the 1q41q42 locus cause a clinically heterogeneous syndrome characterized by developmental delay, characteristic dysmorphic features and brain morphological abnormalities. …”

Novel device for microwave cancer detection by Goh, Chye Ying.

“…Breast cancer is one of the leading causes of cancer deaths among women and early detection leads to earlier treatment and improve survival rates. …”
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Pan-cancer analysis of whole genomes by ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

“…A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes.…”

Probiotic extracellular vesicles engineering for colorectal cancer by Tan, Jing Ren

“…Colorectal cancer (CRC) has been one of the leading causes for cancer-related deaths globally. …”
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Cervicitis decidualis mimicking cervical cancer in pregnancy by Soleymani majd, H, Gaitskell, K, Johnson, C, Hellner, K

“…Cervical decidual reaction in pregnancy is a common finding. In rare cases, these changes can mimic the appearance of invasive cervical cancers. …”

The involvement of hypoxia in APOBEC-mediated mutagenesis in multiple cancers by Liang, J

“…<p>Mutational signatures have been studied to associate mutations to their originating causes. One such signature is that of the APOBEC family of proteins. …”

Breast cancer susceptibility : accessing newly discovered SNPs by Loh, Eunice Ting Wei

“…Breast cancer susceptibility has been found to exhibit familial aggregation, caused by underlying genetic factors contributing to its risks. …”
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Investigating the effects of IGFs on immune responses in prostate cancer by Kim, J

“…RNA sequencing of the tumours revealed inflammatory and senescence-associated secretory phenotype (SASP)-like signatures, suggesting cellular stress caused by the IGF axis blockade. In conclusion, IGF axis contributes to remodelling of prostate cancer TIME, with species-dependent changes in immune cell repertoire. …”