Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML by Risueño, A, See, WL, Bluemmert, I, de Botton, S, DiNardo, CD, Fathi, AT, Schuh, AC, Montesinos, P, Vyas, P, Prebet, T, Gandhi, A, Hasan, M

“…We recently reported results from the phase 3 IDHENTIFY trial (NCT02577406) showing improved response rates and event-free survival with enasidenib monotherapy compared with conventional care regimens (CCR) in heavily pretreated, older patients with late-stage R/R AML bearing IDH2 mutations. Here we investigated the prognostic impact of mutational burden and different co-mutation patterns at study entry within the predominant IDH2 variant subclasses, IDH2-R140 and IDH2-R172. …”

How to Hold a Grudge : From Resentment to Contentment- the Power of Grudges to Transform Your Life / by Hannah, Sophie, 1971- author 649175

“…But aren't we supposed to just forgive, forget, and move on? Bearing a grudge is too negative, right? Wrong! Grudges, when held correctly, are an essential part of a healthy psychological diet. …”

Aminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acids by Chi, Robin Yonggui, Xu, Jianfeng, Chen, Xingkuan, Wang, Ming, Zheng, Pengcheng, Song, Bao-An

“…This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.…”
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Understanding systemic cooling poverty by Mazzone, A, De Cian, E, Falchetta, G, Jani, A, Mistry, M, Khosla, R

“…The poorest and most disadvantaged people, who contributed the least to global warming, are the ones bearing the most severe consequences of extreme heat because of their limited adaptive capacity. …”

Soil solution compositions and mineralogy of some active acid sulfate soils in Malaysia as affected by laboratory incubation with lime by Shamshuddin, J., Auxtero, E.A.

“…Acid sulfate soils in Malaysia are developed when pyrite bearing deposits in the coastal plains are drained for agricultural production. …”

Synthesis of a π-extended azacorannulenophane enabled by strain-induced 1,3-dipolar cycloaddition by Zhang, Xinjiang, Mackinnon, Marc R., Bodwell, Graham J., Ito, Shingo

“…The first example of a cyclophane bearing a nitrogen-containing buckybowl was synthesized via sequential 1,3-dipolar cycloaddition and palladium-catalyzed intramolecular cyclization. …”
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Ancient Tangut manuscripts rediscovered by van Driem, George

“…It is a cause for great joy that, since the appearance of the article by van Driem and Kepping (1991), the original Tangut manuscripts bearing interlinear Tibetan transcriptions, which had been lost for decades, have now been found and returned to the Institute of Oriental Studies in St. …”
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Port service quality in the supply chain management context by Poh, Patricia Xiang Qi.

“…Hence, the standard of performance by the ports has a bearing effect on the rest of the supply chain.…”
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A Pilot Study to Evaluate the Relationships between Supine Proprioception Assessments and Upright Functional Mobility by Bellisle, Rachel F., Peters, Brian T., Oddsson, Lars, Wood, Scott J., Macaulay, Timothy R.

“…We developed a tilt board mounted vertically with a horizontal air-bearing sled as a potential supine assessment tool for a future bedrest study. …”
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Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration by Yan, Jianming, Yoshikai, Naohiko

“…We report herein that the cobalt/arylzinc combination can also promote a cascade arylative cyclization reaction of alkynes bearing pendant ester or ketone moieties to afford benzo-fused cyclic ketone or alcohol products, respectively. …”
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Stress analysis and stress intensity factor computation of DNV X65 pipes subjected to four point bending by Lee, Shaun Raphael Kwok Yuen

“…Proposed solution by Baik-Yamada for the shifting in neutral axis as a result of changing area of remaining load bearing ligament is also compared with finite element results. …”
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Computational and experimental study of a platinum thin-film based oil condition and contamination sensor by Sridhar, V, Chana, KS, Singh, D

“…Oil contamination occurs when metallic or non-metallic particles are produced due to wear of the machine components such as bearings, gears etc. and these particles may not be always captured by the filtering system that are already in the lubrication system. …”

Photo-modulable molecular transport junctions based on organometallic molecular wires by Meng, Fanben, Hervault, Yves-Marie, Norel, Lucie, Costuas, Karine, Dyck, Colin Van, Geskin, Victor, Cornil, Jérôme, Hng, Huey Hoon, Rigaut, Stéphane, Chen, Xiaodong

“…Photo-modulable molecular transport junctions are developed via on-wire lithography-fabricated nanogaps functionalized with a dithienylethene unit bearing two ruthenium fragments. A reversible and repeatable bi-state conductive switching upon alternate irradiation of UV and visible light can be distinctly observed. …”
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5G in Singapore : is the tide turning against Huawei? by Anuar, Amalina

“…Along with other countries also opting for non-Chinese 5G equipment, US Secretary of State Mike Pompeo declared this as evidence of Washington’s anti-Huawei campaign bearing fruit.…”
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Experimental investigation into load settlement characteristics of piled rafts in sand by Leong, Hazel Xueling.

“…Studies by many notable researchers in the years to come suggest that the most effective combinations of piles and raft happens when all the initial loading can be borne with the raft’s bearing capacity alone. The role of the piles was solely to reduce the excessive settlement experienced by the plain raft.…”
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Dense/porous bioceramic composites by Hu, Yifei

“…The pores were designed for bone ingrowth, whereas the graded pores and the dense cores were introduced for load bearing capability. For bone ingrowth, the porous structures must have a high porosity, a high interconnectivity, and a suitable pore size.…”
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Photodynamic bubble-generating microneedles for enhanced transdermal cancer therapy by Ning, Xiaoyu, Chen, Si, Yang, Yating, Hwang, Jangsun, Wiraja, Christian, Zhang, Chi, Liu, Wei, Liu, Linbo, Xu, Chenjie

“…The drug delivery efficiency of this platform is first evaluated ex vivo using fresh mouse skins and human keloid tissues. Later, in the tumor-bearing mouse model, the platform enhances the skin penetration of photosensitizers (i.e., methylene blue) and correspondingly improves the efficacy of photodynamic therapy.…”
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Mechanics of Three-Dimensional Micro-Architected Interpenetrating Phase Composites by Chen, Andrew Y.

“…We show that independent of the material system, the presence of a load-bearing matrix distributes the stress in the composite, contributing to a high-strength, globally stretchingdominated failure behavior, regardless of nodal connectivity. …”
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Another philosophical look at twistor theory by Gajic, G, Lilani, N, Read, J

“…In this article, we (a) present for philosophers an introduction to twistor theory, (b) consider how the spacetime–twistor correspondence interacts with the philosophical literature on theoretical equivalence, and (c) explore the bearing which twistor theory might have on philosophical issues such as the status of dynamics, the geometrisation of physics, spacetime ontology, the emergence of spacetime, and symmetry-to-reality inferences. …”

Content routing and lookup schemes using global bloom filter for content-delivery-as-a-service by Jin, Yichao, Wen, Yonggang

“…The global CCBF adds our system with the capability to early check the existence of any specific content among all the peering surrogates, before any local checking on each cache node. …”
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