Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies by Hunter, B, Li, M, Parker, BL, Koay, YC, Harney, DJ, Pearson, E, Cao, J, Chen, GT, Guneratne, O, Smyth, GK, Larance, M, O’Sullivan, JF, Lal, S

“…Inter-ventricular significance of these metabolic pathways was then found to be diminished within end-stage dilated cardiomyopathy and ischaemic cardiomyopathy, while heart failure-associated pathways were increased in the left ventricle relative to the right within ischaemic cardiomyopathy, such as fluid sheer-stress, increased glutamine-glutamate ratio, and down-regulation of contractile proteins, indicating a left ventricular pathological bias.…”

Large scale paired antibody language models by Kenlay, H, Dreyer, FA, Kovaltsuk, A, Miketa, D, Pires, D, Deane, CM

“…With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in the design of better therapeutics has been constrained by the sheer volume and complexity of the data. To address this challenge, we present IgBert and IgT5, the best performing antibody-specific language models developed to date which can consistently handle both paired and unpaired variable region sequences as input. …”

Quality over quantity: powering neuroimaging samples in psychiatry by Makowski, C, Nichols, TE, Dale, AM

“…In this review, we encourage this discourse to shift from a focus on sheer increases in sample size to more thoughtful choices surrounding experimental study designs. …”

Digital problem-based learning in health professions : systematic review and meta-analysis by the digital health education collaboration by Car, Lorainne Tudor, Kyaw, Bhone Myint, Dunleavy, Gerard, Smart, Neil A., Semwal, Monika, Rotgans, Jerome Ingmar, Low-Beer, Naomi, Campbell, James

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Ancient Art, Modern Tech: Experiencing the Digital Reinvention of the Mogao Grottoes by Zhao, Celina

“…But now it must confront the greatest challenge to its continued existence: modern-day tourism. The sheer volume of visitors seeking a direct experience of this unique but delicate site has resulted in an increasingly rapid process of destruction in the 21st century. …”
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Design, synthesis, characterization and property study of topological structures of DNA by Li, Dawei

“…It is demonstrated in the current studies for the first time that the shapes of DNA writher (toroidal and interwound forms) can be precisely created sheerly through maneuvering the sequence of DNA and with no involvement of topological enzymes. …”
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Biovalorisation of brewer's spent grain (BSG) and sensory evaluation of BSG bread by Goh, Luo Lin

“…Brewer’s spent grain (BSG) is the largest by-product of beer production, generating over an approximate 38 billion kg annually. …”
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Wind tunnel design and fabrication for lift force investigation by Kong, Shao Ming

“…As wind tunnels are resource intensive equipment, its potential as a learning aid is greatly hampered due to the sheer cost and logistics involved in the operation of a full sized wind tunnel. …”
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Ig.n.is. by Ong, Jian'an.

“…This spectrum does not appear suddenly, nor was it by sheer chance. There is a cascading effect on successive development of thought and spirituality that led to where we are, who we are, and why do we behave the way we do.…”
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Aggregating and analyzing Indian political tweets by Chirag Ruhela

“…Understanding this huge data-set in its raw form is not possible due to the sheer dimensionality of the data-set. Thus dimensionality reduction and clever insightful visualizations are needed to make this data consumable for general public. …”
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Material extrusion-based printing optimization of recycled HDPE filaments made from used milk jugs by Teng, Phillis Soek Po, Tee, Chor Hiong, Tan, Hwee Boon, Leong, Kah Fai

“…High-density polyethylene (HDPE) is a widely used thermoplastic material for product packaging. The sheer availability of recyclable or recycled HDPE (rHDPE) from used packaging has led to efforts to apply it in MEX printing. …”
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Edge/cloud resource management for time-sensitive applications by Lim, Her Huey

“…Technological advancements and skyrocketing interest in areas such as Artificial Intelligence and Internet of Things as well as the sheer increase in development of software solutions, tools, infrastructure, and more have driven demand for cloud resources to staggering heights. …”
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SyROCCo: enhancing systematic reviews using machine learning by Fang, Z, Arana-Catania, M, van Lier, F-A, Outes Velarde, J, Bregazzi, H, Airoldi, M, Carter, E, Proctor, R

“…The sheer number of research outputs published every year makes systematic reviewing increasingly time- and resource-intensive. …”

HIV decision support : from molecule to man by Sloot, Peter M. A., Coveney, P. V., Muller, V., Boucher, Charles A. B., Ertaylan, Gokhan, Bubak, Marian

“…Effective highly active antiretroviral therapy and the availability of genetic screening of patient virus data have led to sustained viral suppression and higher life expectancy in patients who have been infected with HIV. The sheer complexity of the disease stems from the multiscale and highly dynamic nature of the system under study. …”
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Efficient top-k continuous query processing over sliding window model (SWM) method on uncertain data stream by Wahab, Raja Azhan Syah Raja, Rum, Siti Nurulain Mohd, Ibrahim, Hamidah, Ishak, Iskandar

“…As a result of both the sheer amount of data generated and the rate of change, traditional processing methods are in dire need of an upgrade. …”
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Biovalorisation of food waste in Singapore : synergistic effect of a mixed culture in solid-state fermentation by Ong, Adwin Reng Jun

“…Okara and brewer’s spent grain (BSG) are manufacturing side streams produced in massive amounts from the soy and beer industries, respectively, and contributes significantly to food waste. …”
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Application of smartphone-based biophotonic instrumentation for glucose sensing using colorimetric method by Azlan, Nur Ainin Sofhia Nurul

“…The calibration curves consistently confirm that the proposed method aligns with the Beer-Lambert law, in accordance with expectations with previous studies. …”
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Brewers’ spent grains as potential novel functional food ingredients for food security by Tan, Yong Xing

“…BSG are residues generated as side streams from beer production. Currently, BSG are used as animal feed or disposed in landfills and these massive amount of BSG generated annually are causing significant environmental, economic, and climatic issues. …”
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Physical unclonable function based solutions to unification of user, device and data authentication by Zheng, Yue

“…The non-repudiation assumption of these conventional techniques is being challenged by emerging artificial-intelligent assisted and malware-based attacks on independently chained weak links (factors), and their limited extension to IoT scenarios, where the sheer number of inexpensive and often insufficiently protected endpoints prevent application of standard, secret-key based techniques. …”
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