Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…Additionally, we uncover an association between microglia and blood vessels in fetal brains exposed to maternal SARS-CoV-2. These findings offer insights into whether various microglial phenotypes form networks in the developing brain to occupy space, and in conditions involving haemorrhages, whether microglia respond to, or influence changes in blood vessel integrity. …”

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England by Copland, E, Patone, M, Saatci, D, Handunnetthi, L, Hirst, J, Hunt, DPJ, Mills, NL, Moss, P, Sheikh, A, Coupland, CAC, Harnden, A, Robertson, C, Hippisley-Cox, J

“…An additional 12 (95%CI 0–23) hospitalisations with epilepsy and 4 (95%CI 0–6) with demyelinating disease (in females only, mainly optic neuritis) were estimated per million following a second dose with BNT162b2. SARS-CoV-2 infection was associated with increased risks of hospitalisation from seven outcomes including multisystem inflammatory syndrome and myocarditis, but these risks were largely absent in those vaccinated prior to infection. …”

Inaudible echo-based indoor position recognition by Wong, Alexander Chong Xan

“…An example where accurate indoor localisation would be useful is contact tracing to limit the spread of the SARS-CoV-2 virus amid the Covid-19 pandemic. Prior Research has been conducted in this field, the most noteworthy is RoomRecognise. …”
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TPepRet: a deep learning model for characterizing T-cell receptors–antigen binding patterns by Wang, M, Fan, W, Wu, T, Li, M

“…We have evaluated TPepRet to a range of challenging scenarios, including performance benchmarking against other tools using diverse datasets, analysis of peptide binding preferences, characterization of T cells clonal expansion, identification of true binder in complex environments, assessment of key binding sites through alanine scanning, validation against expression rates from large-scale datasets, and ability to screen SARS-CoV-2 TCRs. The comprehensive results suggest that TPepRet outperforms existing tools. …”

Fast and accurate variant identification tool for sequencing-based studies by Gaston, Jeffry M., Alm, Eric J., Zhang, An-Ni

“…This accuracy extends to variant identification in virus samples, including SARS-CoV-2, particularly with significantly fewer false negative indels than bcftools. …”
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Site-specific chemical and topological modifications to augment mRNA therapeutic potential by Aditham, Abhishek J.

“…Despite clinical demonstrations of mRNA for SARS-CoV-2 vaccines, mRNAs remain limited in application by their susceptibility to nucleases and overall short expression lifetime in vivo. …”
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The Pandemic EVIDENCE Collaboration Pillar 1: diagnostics and transmission by Conly, J, Plüddemann, A, Jefferson, T, Rosca, C, Heneghan, C

“…The evidence produced to support the optimal deployment of NPIs to reduce transmission of SARS-CoV-2 was often of poor quality, and decisions were made without considering the wealth of previous research on respiratory virus transmission from human challenge studies. …”

The Pandemic EVIDENCE Collaboration Pillar 2: interventions and evidence by Fretheim, A, Onakpoya, I, Bartoszko, J, Jones, M, Gandini, S

“…The use of non-pharmacological interventions (NPIs) on a global scale to reduce the transmission of SARS-CoV-2 was unprecedented. However, there was a lack of high-quality evidence to fully understand the benefits and harms of these interventions. …”

The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. …”
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The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis by Singh, S, Boyd, S, Schilling, WHK, Watson, JA, Mukaka, M, White, NJ

“…Treatment benefit was defined clinically as the relative risk of hospitalization/death during follow-up (≥14 days), and virologically as the SARS-CoV-2 viral clearance rate ratio (VCRR). The VCRR is the ratio of viral clearance rates between the intervention and control arms. …”

Multicenter diagnostic evaluation of onsite COVID-19 Rapid Test (CTK Biotech) among symptomatic individuals in Brazil and the United Kingdom by Thompson, CR, Torres, PM, Kontogianni, K, Byrne, RL, LSTM Diagnostic group, Noguera, SV, Luna-Muschi, A, Marchi, AP, Andrade, PS, Dos Santos Barboza, A, Nishikawara, M, CONDOR steering group, Body, R, de Vos, M, Escadafal, C, Adams, E, Figueiredo Costa, S, Cubas-Atienzar, AI

“…Concurrently, analytical evaluation of the Ag-RDT was assessed using direct culture supernatant of SARS-CoV-2 strains from wild-type (WT), Alpha, Delta, Gamma, and Omicron lineages. …”

Brewers’ spent grains as potential novel functional food ingredients for food security by Tan, Yong Xing

“…BSG are residues generated as side streams from beer production. Currently, BSG are used as animal feed or disposed in landfills and these massive amount of BSG generated annually are causing significant environmental, economic, and climatic issues. …”
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Wastewater-based epidemiology for preventing outbreaks and epidemics in Latin America - lessons from the past and a look to the future by Prado, Tatiana, Rey-Benito, Gloria, Miagostovich, Marize Pereira, Sato, Maria Inês Zanoli, Rajal, Veronica Beatriz, Filho, Cesar Rossas Mota, Pereira, Alyne Duarte, Barbosa, Mikaela Renata Funada, Mannarino, Camille Ferreira, da Silva, Agnes Soares

“…Despite the historical uses of this approach, particularly in the Global Polio Eradication Initiative, and for other pathogens, it was during the COVID-19 pandemic that occurred an exponential increase in environmental surveillance programs for SARS-CoV-2 in wastewater, with many experiences and developments in the field of public health using data for decision making and prioritizing actions to control the pandemic. …”
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Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in... by Png, ME, Harris, V, Grabey, J, Hart, ND, Jani, BD, Butler, D, Carson-Stevens, A, Coates, M, Cureton, L, Dobson, M, Dorward, J, Evans, P, Francis, N, Gbinigie, OA, Hayward, G, Holmes, J, Hood, K, Khoo, S, Ahmed, H, Lown, M, McKenna, M, Mort, S, Nguyen-Van-Tam, J, Rahman, N, Richards, DB, Thomas, N, van Hecke, O, Hobbs, FR, Little, P, Yu, L-M, Butler, CC, Petrou, S

“…<p><strong>Background </p></strong>The cost-effectiveness of molnupiravir, an oral antiviral for early treatment of SARS-CoV-2, has not been established in vaccinated populations. …”

Environmental contamination in a coronavirus disease 2019 (COVID-19) intensive care unit—what is the risk? by Ong, Sean Wei Xiang, Lee, Pei Hua, Tan, Yian Kim, Ling, Li Min, Ho, Benjamin Choon Heng, Ng, Ching Ging, Wang, Dong Ling, Tan, Boon Huan, Leo, Yee Sin, Ng, Oon Tek, Wong, Michelle Su Yen, Marimuthu, Kalisvar

“…The risk of environmental contamination by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in the intensive care unit (ICU) is unclear. …”
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Rapid electrochemical detection of COVID-19 genomic sequence with dual-function graphene nanocolloids based biosensor by Ang, Wei Li, Lim, Rachel Rui Xia, Ambrosi, Adriano, Bonanni, Alessandra

“…Discovered in December 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (aka SARS-CoV-2 or 2019-nCoV) has attracted worldwide attention and concerns due to its high transmissibility and the severe health consequences experienced upon its infection, particularly by elderly people. …”
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The determinants of COVID-19 morbidity and mortality across countries by Chang, Dianna, Chang, Xin, He, Yu, Tan, Kelvin Jui Keng

“…For healthcare factors, SARS (severe acute respiratory syndrome) experience and healthcare infrastructure help countries perform better in combating the pandemic.…”
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Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide by Meher, Geetanjali, Bhattacharjya, Surajit, Chakraborty, Hirak

“…The N-terminal fusion peptide (residues 770-788) of an S2 glycoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV), exposed upon receptor binding, is crucial for virus entry into the host cell. …”
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Best practices for ports and shipping companies to build resilience against pandemics by Tan, Hui En

“…The maritime industry has experienced similar kinds of pandemic outbreaks (SARS and Avian Flu), but they still faltered in the face of COVID-19. …”
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Strategies to increase response rate and reduce non-response bias in population health research: a series of randomised controlled trials during a large COVID-19 study by Atchison, CJ, Gilby, N, Pantelidou, G, Clemens, S, Pickering, K, Chadeau-Hyam, M, Ashby, D, Barclay, WS, Cooke, G, Darzi, A, Riley, S, Donnelly, C, Ward, H, Elliott, P

“…</p> <br> <p><strong>Methods:</strong> Over 19 rounds, a random sample of individuals aged 5 years and older from the general population in England were invited by mail to complete an online questionnaire and return a swab for SARS-CoV-2 testing. We carried out several nested randomised controlled experiments to measure the impact on response rates of different interventions, including (1) variations in invitation and reminder letters and text messages, and (2) the offer of a conditional monetary incentive to return a swab, reporting absolute changes in response and relative response rate (RRR with 95% Confidence Intervals).…”