Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…The timings of conversion of AA (confirmed or withdrawn) were assessed and found to be consistent across decades and to have some dependency upon the broad disease area (when assessed by three large groups: HIV conversions were fastest; followed by oncology; followed by all others). …”
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Effects of electromagnetic field on proliferation, differentiation, and mineralization of MC3T3 cells by Teoh, Swee-Hin, Suryani, Luvita, Too, Jian Hui, Hassanbhai, Ammar Mansoor, Wen, Feng, Lin, Daryl Jimian, Yu, Na

“…After 7 days of PEMF exposure, in comparison with negative controls, cell numbers increased when exposed to PEMF in culture medium and were independent of osteogenic supplements. …”
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History dependence of the microstructure on time-dependent deformation during in-situ cooling of a nickel-based single-crystal superalloy by Panwisawas, Chinnapat, D’Souza, Neil, Collins, David M., Bhowmik, Ayan, Roebuck, Bryan

“…The saturation stresses in the flow stress experiments show very good agreement with the stresses measured in the cooling experiments when viscoplastic deformation is dominant. This study demonstrates that experimentation during high-temperature deformation as well as the history dependence of the microstructure during cooling plays a key role in deriving an accurate viscoplastic constitutive law for the thermo-mechanical process during cooling from solidification.…”
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Synthesis of Au@Pd core/shell nanomaterials for high-performance ethanol oxidation reactions by Xu, Weichang

“…The deposited amount of Pd can be tuned by the concentration of Pd precursor. When the concentration of PdCl2 was reduced to 2.5 mM, the Au surface would be partially coated with Pd domains and the CV scan could facilitate the physical movement of Pd atoms to realize full coverage of the exposed Au surface. …”
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Liposomal nanotherapy for treatment of atherosclerosis : passive versus active targeting by Darwitan, Anastasia

“…Anti-inflammatory agents, such as glucocorticoids (GC), when administered systemically for long duration, are associated with systemic adverse effect. …”
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…The effect was maximal when KCa3.1 activation and Kv11.1 inhibition were combined. …”
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Feature extraction from EEG signals and regularization for brain-computer interface by Mishuhina, Vasilisa

“…MI-BCI establishes communication through signal generated from the human brain when a person is imagining the movement of some part of the body. …”
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Scaffold-mediated sustained, non-viral delivery of miR-219/miR-338 promotes CNS remyelination by Milbreta, Ulla, Lin, Junquan, Pinese, Coline, Ong, William, Chin, Jiah Shin, Shirahama, Hitomi, Mi, Ruifa, Williams, Anna, Bechler, Marie E., Wang, Jun, ffrench-Constant, Charles, Hoke, Ahmet, Chew, Sing Yian

“…At the host-implant interface, more compact myelin sheaths were observed when animals received miR-219/miR-338. Similarly within the scaffolds, miR-219/miR-338 samples contained significantly more myelin basic protein (MBP) signals (p < 0.01) and higher myelination index (p < 0.05) than Neg miR samples. …”
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Improving patient outcomes following total knee arthroplasty : identifying rehabilitation pathways based on modifiable psychological risk and resilience factors by Ditton, Elizabeth, Johnson, Sarah, Hodyl, Nicolette, Flynn, Traci, Pollack, Michael, Ribbons, Karen, Walker, Frederick Rohan, Nilsson, Michael

“…Total knee arthroplasty (TKA) is a commonly implemented elective surgical treatment for end-stage osteoarthritis of the knee, demonstrating high success rates when assessed by objective medical outcomes. However, a considerable proportion of TKA patients report significant dissatisfaction postoperatively, related to enduring pain, functional limitations, and diminished quality of life. …”
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Sensitivity study of weather research and forecasting physical schemes and evaluation of cool coating effects in Singapore by weather research and forecasting coupled with urban ca... by Zhou, Mandi, Long, Yongping, Zhang, Xiaoqin, Donthu, Eswara V. S. K. K., Ng, Bing Feng, Wan, Man Pun

“…Maximum UHI intensity of 3.2°C is found at nighttime (21:00) at a hot spot in the Commercial/Industrial area. At nighttime, when the UHI effect is generally more intense than daytime, applying cool coating on all urban surfaces can reduce the UHI effect by about 30% in residential areas and about 6% in commercial/industrial areas. …”
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The impact of death and dying on the personhood of medical students : a systematic scoping review by Ho, Chong Yao, Kow, Cheryl Shumin, Chia, Joshua Chin Howe, Low, Jia Ying, Lai, Melvin Yong Hao, Lauw, Sarah-Kei, How, Ashley Ern Hui, Tan, Lorraine Hui En, Ngiam, Lisa Xin Ling, Chan, Natalie Pei Xin, Kuek, Joshua Tze Yin, Nur Haidah Ahmad Kamal, Chia, Jeng Long, Ahmad Hanifah Marican Abdurrahman, Chiam, Min, Ong, Yun Ting, Chin, Annelissa Mien Chew, Toh, Ying Pin, Mason, Stephen, Krishna, Lalit Kumar Radha

“…Background: The re-introduction of medical students into healthcare systems struggling with the COVID-19 pandemic raises concerns as to whether they will be supported when confronted with death and dying patients in resource-limited settings and with reduced support from senior clinicians. …”
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Cognizant multitasking in multiobjective multifactorial evolution : MO-MFEA-II by Bali, Kavitesh Kumar, Gupta, Abhishek, Ong, Yew-Soon, Tan, Puay Siew

“…The capacity of artificial intelligence systems to mimic such cognitive behaviors for effective problem solving is deemed invaluable, particularly when tackling real-world problems where speed and accuracy are critical. …”
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Dual role of Cu-chalcogenide as hole-transporting layer and interface passivator for p–i–n architecture perovskite solar cell by Sadhu, Anupam, Rai, Monika, Salim, Teddy, Jin, Xin, Tan, Joel Ming Rui, Leow, Shin Woei, Ahmed, Mahmoud Gamal, Magdassi, Shlomo, Mhaisalkar, Subodh Gautam, Wong, Lydia Helena

“…However, in p–i–n architecture when these inorganic HTLs are deposited before the perovskite, it forms a suboptimal interface quality for the crystallization of perovskite, which reduces device stability, causes recombination, and limits the power conversion efficiency of the device. …”
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Three essays on behavioral and experimental economics by Li, Yupeng

“…Our results show that people exhibited a lower degree of loss aversion when the payoff information was conveyed using a pronoun that induced a higher level of self-distancing. …”
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Synthesis of metal nanomaterials with unconventional crystal phases and their applications in electrocatalysis by Liu, Jiawei

“…These nanorods, with similar size and morphology, but different crystal phases, provide an effective platform to explore the crystal phase-dependent catalytic applications. When they are employed as electrocatalysts toward the electrochemical ethanol oxidation reaction (EOR) in alkaline media, both the mass activity and stability follow the trend that the L12 PdCuSn > L12 Pd3Sn > fcc Pd3Sn > Pd/C, demonstrating the significance of alloying effect and crystal phase in determining their catalytic performance.…”
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Anisotropic hair keratin-dopamine composite scaffolds exhibit strain-stiffening properties by Zhao, Zhitong, Chua, Huei Min, Goh, Bernice Huan Rong, Lai, Hui Ying, Tan, Shao Jie, Moay, Zi Kuang, Setyawati, Magdiel Inggrid, Ng, Kee Woei

“…However, none of the reported HHK based scaffolds is able to replicate the strain-stiffening capacity of living tissues when responding to large deformations. In the present study, strain-stiffening property was achieved in scaffolds fabricated from HHK via a synergistic effect of well-defined, aligned microstructure and chemical crosslinking. …”
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Principled asymmetric boosting approaches to rapid training and classification in face detection by Pham, Minh Tri

“…An additional constraint on propagating the weights of the data points is introduced, allowing the online learning to converge faster. When compared with the Online Boosting algorithm recently applied to object detection problems, a 0-10% increase in accuracy and 5-30% gain in learning speed were observed. …”
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Understanding lay conceptions of workplace criers: a prototype analysis by Tan, Terri Su-May

“…These issues present crucial gaps in this nascent area of research, and potentially compromise validity when subsequently predicting downstream consequences for workplace criers. …”
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Translational GTPase BipA is involved in the maturation of a large subunit of bacterial ribosome at suboptimal temperature by Goh, Kwok Jian, Ero, Rya, Yan, Xin-Fu, Park, Jung Eun, Kundukad, Binu, Zheng, Jun, Sze, Siu Kwan, Gao, Yong-Gui

“…BipA binds to the aminoacyl-(A) site of the bacterial ribosome and establishes contacts with the functionally important regions of both subunits, implying a specific role relevant to the ribosome, such as functioning in ribosome biogenesis and/or conditional protein translation. When cultured at suboptimal temperatures, the Escherichia coli bipA genomic deletion strain (ΔbipA) exhibits defects in growth, swimming motility, and ribosome assembly, which can be complemented by a plasmid-borne bipA supplementation or suppressed by the genomic rluC deletion. …”
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Nano-engineering the evolution of skyrmion crystal in synthetic antiferromagnets by Ma, Mangyuan, Huang, Ke, Li, Yong, Li, Sihua, Feng, Qiyuan, Ang, Calvin Ching Ian, Jin, Tianli, Lu, Yalin, Lu, Qingyou, Lew, Wen Siang, Ma, Fusheng, Wang, Renshaw Xiao

“…The out-of-plane magnetization hysteresis loops and first-order reversal curves show that the nucleation and annihilation of the artificial skyrmion can be controlled by tuning the diameter of and spacing between the nanodots. Moreover, when the bottom layer thickness increases, the annihilation of skyrmion shifts from evolving into a ferromagnetic spin texture to evolving into an antiferromagnetic spin texture. …”
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