Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein by Loh, Jia Tong, Teo, Joey Kay Hui, Lam, Kong-Peng

“…However, the precise mechanism controlling calprotectin production during SARS-CoV-2 infection remains elusive. In this study, we showed that Dok3 adaptor restrains calprotectin production by neutrophils in response to SARS-CoV-2 spike (S) protein engagement of TLR4. …”
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The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

“…These results unveil a novel, multi-faceted mechanism by which SARS-CoV-2 evades the host’s defenses and manipulates cellular components. …”

Design of a Four-Bar Latch Mechanism and a Shear-Based Rotary Viscous Damper for Single-Axis Prosthetic Knees by Arelekatti, VN Murthy, Petelina, Nina T, Johnson, W Brett, Major, Matthew J, Winter V, Amos G

“…The damping module was implemented with a concentric stack of stationary and rotating pairs of plates that shear thin films of high-viscosity silicone oil. …”
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Ultrasonic welding of novel carbon/Elium® thermoplastic composites with flat and integrated energy directors : lap shear characterisation and fractographic investigation by Bhudolia, Somen K., Gohel, Goram, Kantipudi, Jayaram, Leong, Kah Fai, Jr., Robert J. Barsotti

“…The ED integrated configuration showed the best welding results with a lap shear strength of 18.68 MPa. The morphological assessment has shown significant plastic deformation of Elium® resin and the shear cusps formation, which enhances the welding strength. …”
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Functional amyloids in Pseudomonas aeruginosa may be involved in the sequestration of the quorum sensing molecules HHQ and PQS under high shear conditions. by Sia, Wan Rong.

“…Results from the investigations revealed that Fap binds to QS molecules at high affinities and was able to retain them under high shear force. Therefore, we propose that Fap has a functional role in sequestering QS molecules under high shear conditions.…”
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A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Endothelial cells sense fluid shear stress (FSS) from blood flow to maintain FSS within a narrow range in healthy vessels. …”

COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection by Mahyuddin, Aniza P., Swa, Hannah L. F., Weng, Ruifen, Zhang, Jingxian, Dhanaraj, Janice P., Sesurajan, Binny P., Rauff, Mary, Dashraath, Pradip, Kanneganti, Abhiram, Lee, Rachel, Wang, Lin-Fa, Young, Barnaby Edward, Tambyah, Paul A., Lye, David C., Chai, Louis Y. A., Yee, Sidney, Choolani, Mahesh, Mattar, Citra N. Z.

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Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses by Scheim, David E., Parry, Peter I., Rabbolini, David J., Aldous, Colleen, Yagisawa, Morimasa, Clancy, Robert, Borody, Thomas J., Hoy, Wendy E.

“…Notably, the two human betacoronaviruses that express a sialic acid-cleaving enzyme are benign, while the other three—SARS, SARS-CoV-2 and MERS—are virulent. RBC aggregation experimentally induced in several animal species using an injected polysaccharide caused most of the same morbidities of severe COVID-19. …”
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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

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A 9.87 nW 1 kS/s 8.7 ENOB SAR ADC for implantable epileptic seizure detection microsystems by Do, Anh Tuan, Lam, Chun Kit, Tan, Yung Sern, Yeo, Kiat Seng, Cheong, Jia Hao, Yao, Lei, Tan, Meng Tong, Je, Minkyu

“…This paper presents an ultra low-power SAR ADC in 0.18 μm CMOS technology for epileptic seizure detection applications. …”
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Magnetohydrodynamic motions of oldroyd-b fluids in infinite circular cylinder that applies longitudinal shear stresses to the fluid or rotates around its axis by Vieru, Dumitru, Fetecau, Constantin, Zulkhibri, Ismail

“…General expressions are firstly established for shear stress and velocity fields corresponding to the motion induced by longitudinal shear stress on the boundary. …”
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HyMap imagery for copper and manganese prospecting in the east of Ameln valley shear zone (Kerdous inlier, western Anti-Atlas, Morocco) by Hajaj, Soufiane, El Harti, Abderrazak, Jellouli, Amine, Pour, Amin Beiranvand, Himyari, Saloua Mnissar, Hamzaoui, Abderrazak, Bensalah, Mohamed Khalil, Benaouiss, Naima, Hashim, Mazlan

Examining the effects of relative advances in higher mobility roads over higher accessibility roads and income inequality on the relationship between car ownership and economic growth by Poi, Alvin Wai Hoong, Law, Teik Hua, Hamid, Hussain, Mohd Jakarni, Fauzan, Ishak, Siti Zaharah, Ng, Choy Peng

“…Results revealed that passenger car ownership rate is consistently higher at most of the per capita income levels under mid-range MPA and lower income inequality conditions. …”

Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…We demonstrated that the production of SARS-CoV-2 VLPs using this cell pool was scalable up to a stirred-tank 2 L bioreactor in fed-batch mode. …”
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Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain by Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D, Nussenzweig, Michel C, Chakraborty, Arup K

“…The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing antibodies. …”
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Volume change and collapse potential of unsaturated residual granite soil by Mehrdad Kholghifard

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Dynamics of SARS-CoV-2 infection over two epidemic waves in Manaus, Brazil: A serological study of seven thousand blood donors by Alexander, N, Dye, C, Busch, MP, Buss, L, Prete, CA, Brady, OJ, Mee, P, Abrahim, CMM, Crispim, MAE, da Costa, AG, Salomon, T, Mayaud, P, Oikawa, MK, Faria, NR, Sabino, EC

“…Seroconversion was inferred by a mixture model for serial values from the Abbott Architect SARS-CoV-2 nucleocapsid (N) IgG assay. We estimated the number of suspected COVID-19 hospitalizations arising from each infection over calendar time. …”

The cellular characterization of SARS-CoV-2 spike protein in virus-infected cells using the receptor binding domain binding specific human monoclonal antibodies by Chan, Conrad En-Zuo, Ng, Ching-Ging, Lim, Angeline Pei-Chew, Seah, Shirley Lay-Kheng, Chye, De-Hoe, Wong, Steven Ka-Khuen, Lim, Jie-Hui, Lim, Vanessa Zi-Yun, Lai, Soak-Kuan, Wong, Pui-San, Leong, Kok-Mun, Liu, Yi-Chun, Sugrue, Richard J., Tan, Boon Huan

“…A human monoclonal antibody panel (PD4, PD5, PD7, SC23, and SC29) was isolated from the B cells of convalescent patients and used to examine the S protein in SARS-CoV-2-infected cells. While all five antibodies bound conformational-specific epitopes within SARS-CoV-2 spike (S) protein, only PD5, PD7, and SC23 were able to bind to the receptor binding domain (RBD). …”
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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. …”
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Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

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