Euthanasia. What is the genuine problem? by Giubilini, A

“…Considering documents by physicians, philosophers and the Roman Catholic Church, I will show that (a) ‘euthanasia’ is defined by the intention to bring about a patient’s death, and (b) the distinction between what is intentional and what is not does not represent the morally problematic reason against euthanasia. …”

Identifying mechanisms involved in the resistance of homologous recombination defective Dictyostelium cells to ART inhibitors by Kolb, A

“…We further identify that HR inhibition is toxic for cells disrupted in the single-strand break responding PARP Adprt2, whereas an additional loss of the non-homologous end-joining (NHEJ)-promoting PARP Adprt1a renders cells resistant to the treatment. Accordingly, a defect in NHEJ suppresses PARPi toxicity to HR-defective <em>exo1^-</em> strains which is not dependent on the alternative NHEJ (alt-NHEJ) factors Lig3 and PolQ but instead due to re-activation of HR. …”

How Stories Change Us : A Developmental Science of Stories from Fiction and Real Life / by Reese, Elaine, author 655966

“…Yet reading fictional books and reminiscing about the past both play a special role in children's and adolescents' learning and development, so should be fostered from a young age. …”
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A synthetic biology platform for malaria parasites based on orthogonal transcriptional control by Cárdenas Ramírez, Pablo

“…Malaria is responsible for half a million deaths each year in some of the poorest communities around the world. …”
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COVID-19 and global governance: waking up to a safe new world by Caballero-Anthony, Mely

“…After months of shutting borders and imposing lockdowns in desperate efforts to stop the spread of the disease, countries are now starting to ease restrictions and reopen for business. COVID-19 is a once-in-a-lifetime threat to humanity that has inflicted immeasurable suffering on billions of people. …”
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A systematic review of transanal total mesorectal excision: is this the future of rectal cancer surgery? by Simillis, C, Hompes, R, Penna, M, Rasheed, S, Tekkis, PP

“…<p><b>Conclusion</b></p> TaTME is a feasible and reproducible technique, with good quality of oncological resection. …”

Dynamics of the sub-Ohmic spin-boson model : a comparison of three numerical approaches by Yao, Yao, Duan, Liwei, Lü, Zhiguo, Wu, Chang-Qin, Zhao, Yang

“…In order to probe the validity regimes of the three approaches, we study the dynamics of a qubit coupled to a bosonic bath with and without a local field. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Influenza A virus (IAV) is a major public health problem responsible for the death of half a million people every year worldwide. …”
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Bacteriocin-like peptides encoded by a horizontally acquired island mediate Neisseria gonorrhoeae autolysis by Poncin, K, McKeand, SA, Lavender, H, Kurzyp, K, Harrison, OB, Roberti, A, Melia, C, Johnson, E, Maiden, MCJ, Greaves, DR, Exley, R, Tang, CM

“…Autolysis is a form of programmed cell death (PCD) which is part of the life cycle of remarkably few bacteria and poses an evolutionary conundrum as altruistic death provides no obvious benefit for single-celled organisms. …”

Resolving anticipatory grief and enhancing dignity at the end-of life : a systematic review of palliative interventions by Patinadan, Paul Victor, Tan-Ho, Geraldine, Choo, Ping Ying, Ho, Andy Hau Yan

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Mode of action study for a novel class of antimicrobial polymers against methicillin-resistant Staphylococcus aureus by Shi, Zhenyu

“…Membrane- polarizing cationic polymers have attracted attention due to their low propensity to induce resistance. …”
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Minimally invasive inspection of technical and medical intracavities using a novel opto-digital scheme by Murukeshan Vadakke Matham.

“…Cancer growths found in body cavities, such as colon, are a leading cause of death all over world. Medical intra cavity inspection techniques facilitate the diagnosis of cancers and other diseases, found in the different body cavities, such as nasal cavity, esophagus, colon, bladder, rectum etc. …”
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Mortality forecasts for long-term care subpopulations with longevity risk : a bayesian approach by Kogure, Atsuyuki, Fushimi, Takahiro, Kamiya, Shinichi

“…A major obstacle to developing such a method is lack of data on the number of deaths in LTC subpopulations, which would prevent us from using conventional mortality models such as the Lee-Carter model. …”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…<p>Niemann-Pick disease Type C is a rare, lysosomal storage disorder caused by defects in either <em>NPC1</em> (95% of cases) or <em>NPC2</em>, and characterized by progressive neurodegeneration that ultimately results in premature death. …”

Filamentous oligomer structure reconstruction and a new filament picking method for Cryo-EM micrographs by Xu, Chenrui

“…In another example, Caspase recruitment domains (CARD) also tend to form filaments. They belong to a sub-family of the Death Domain superfamily, whose members play critical roles in cellular apoptotic events and innate immune signaling. …”
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A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies by Gilligan, M, O'Donnell, L, Westbrook, A, Tubridy, N, Riordan, SO, McGuigan, C, Connolly, S, Farrell, M, Waters, P, Irani, SR, Kinsella, JA

“…The co-occurrence of four neuronal cell-surface antibodies in a single patient is exceptionally rare. We report a patient who had a severe encephalitis associated with antibodies to NMDA, Glycine, GABAA and GABAB receptors. …”

Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation by Low, Daren., Chen, Ken-Shiung.

“…Pathway analysis shows that these genes are implicated in three major networks associated with signalin, nervous system development and cell death. Using quantitative reverse transcription PCR (qRT-PCR), we validated the differential expression of genes (Fgf7, Glra1, Mc1r, Nr4a2, Slc5a7 and Epha6) that shows functional relevance to AS phenotype. …”
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Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya by Komba, A, Makani, J, Sadarangani, M, Ajala-Agbo, T, Berkley, J, Newton, CRJC, Marsh, K, Williams, T

“…We found no association between malarial parasitemia and death. <p><strong> Conclusions</p></strong>We found no evidence to support the conclusion that the risk of malaria is higher among children with SCD than it is among children without SCD in a rural area on the coast of Kenya. …”

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I by Liu, X, Zhang, Z, Aguirre, T, Shipton, ML, Fu, L, Du, J, Furkert, D, Qi, J, Chin, AC, Riley, AM, Liu, T, Zhang, X, Potter, BVL, Fiedler, D, Zhu, Y, Fu, C

“…<p><strong>Background and aims:&nbsp;</strong>Atherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis. …”

Assessment of arterial stiffness via measurement of pulse wave velocity a study for the normotensive population by Chang, Serene Wei Nee.

“…Cardiovascular diseases are the number one killer in the world which represents 30% of all global deaths and it is predicted by World Health Organisation to remain the single leading cause of death globally. …”
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