May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Introduction: Elevated blood pressure is a leading modifiable risk factor for death and disability worldwide. …”

Resistant hypertension and mortality: an observational cohort study by de la Sierra, A, Ruilope, LM, Staplin, N, Gorostidi, M, Vinyoles, E, Segura, J, Armario, P, Oliveras, A, Williams, B

DNA fragmentation, an indicator of apoptosis, in cultured black tiger shrimp penaeus monodon infected with white spot syndrome virus (WSSV) by Sahtout, A.H., Hassan, M.D., Shariff, M.

“…Given that DNA fragmentation is generally considered to be a hallmark of apoptosis, the results suggested that apoptosis might be implicated in shrimp death caused by WSSV.…”
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Understanding lived experiences of bereaved parents of children with chronic life-threatening Illness : towards a culture-specific and meaning-oriented narrative E-writing interven... by Dutta, Oindrila

“…This means that every year, both globally and locally, tens of millions of parents, grandparents and extended families are left in a state of despair and devastation due to the death of a young child in the family. …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…Much of this increase in the number of DALYs was due to population growth and ageing, as indicated by a decrease in global age-standardised all-cause DALY rates of 14·2% (95% UI 10·7–17·3) between 2010 and 2019. …”

In vitro anti-cancer and antimicrobial effects of manganese oxide nanoparticles synthesized using Glycyrrhiza uralensis leaves extract on breast cancer cell lines by Althobiti, Maryam Musleh, Alzahrani, Badr, Elderdery, Abozer Y., Alzerwi, Nasser A. N., Rayzah, Musaed, Elkhalifa,, Ahmed M. E., Idrees, Bandar, Bakhsh, Ebtisam, Alabdulsalam, Abdulrahim A., Mohamedain, A., Kumar, Suresh S., Mok, Pooi Ling

“…The leaf extract of GU contains bioactive molecules that act as a reducing or capping agent to form Mn2O3 NPs. …”
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Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets by Faustino, André F., Martins, Ivo C., Carvalho, Filomena A., Castanho, Miguel A. R. B., Maurer-Stroh, Sebastian, Santos, Nuno C.

“…Dengue virus (DENV) causes over 500,000 hospitalizations and 20,000 deaths worldwide every year. Dengue epidemics now reach temperate regions due to globalization of trade and travel and climate changes. …”
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Large and unequal life expectancy declines during the COVID-19 pandemic in India in 2020 by Gupta, A, Hathi, P, Banaji, M, Gupta, P, Kashyap, R, Paikra, V, Sharma, K, Somanchi, A, Sudharsanan, N, Vyas, S

“…Compared to 2019, life expectancy at birth was 2.6 years lower and mortality was 17% higher in 2020, implying 1.19 million excess deaths in 2020. Life expectancy declines in India were larger and had a younger age profile than in high-income countries. …”

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study by Hamill, V, Wong, S, Benselin, J, Krajden, M, Hayes, PC, Mutimer, D, Yu, A, Dillon, JF, Gelson, W, Velásquez García, HA, Yeung, A, Johnson, P, Barclay, ST, Alvarez, M, Toyoda, H, Agarwal, K, Fraser, A, Bartlett, S, Aldersley, M, Bathgate, A, Binka, M, Richardson, P, Morling, JR, Ryder, SD, Barnes, E

Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden... by Bender, RG, Sirota, SB, Swetschinski, LR, Berkley, JA, Eyre, DW, McManigal, B, Pollard, AJ, Roberts, T, Runghien, T, Sartorius, B

“…From 2019 to 2021, during the COVID-19 pandemic and implementation of associated non-pharmaceutical interventions, we estimated a 16·0% (13·1–18·6) decline in the global all-age non-COVID-19 LRI mortality rate, largely accounted for by a 71·8% (63·8–78·9) decline in the number of influenza deaths and a 66·7% (56·6–75·3) decline in the number of RSV deaths. …”

相声剧中的反思议题 ：以《东厂仅一位》为例 = Topics in stand-up comedy : a case study on “The Last One of Ming dynasty” by 杨凯威 Yeong, Hoi Wai

“…Xiangsheng (commonly known as Crosstalk in English), a Chinese folk art performance originated in Beijing, China during the late Qing Dynasty, experience blooming and death in Taiwan. …”
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Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…The alternative lengthening of telomeres (ALT) pathway is a telomerase-independent mechanism for immortalization in cancer cells and is commonly activated in low-grade and high-grade glioma, as well as osteosarcoma. …”

Mortality risks in different subtypes of masked hypertension in the Spanish ambulatory blood pressure monitoring registry by de la Sierra, A, Ruilope, LM, Staplin, N, Stergiou, GS, Williams, B

Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the pre... by Tran-To Su, Chinh, Ouyang, Xuchang, Zheng, Jie, Kwoh, Chee Keong

“…Background: Since late March 2013, there has been another global health concern with a sudden wave of flu infections by a novel strain of avian influenza A (H7N9) virus in China. …”
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The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom:... by Hardy, C, Brand, A, Jones, J, Knight, M, Banfield, P

“…Although short-term outcomes were generally good for mothers and babies, a larger prospective study is required. It is often possible to avoid exposing the baby to iatrogenic prematurity.…”

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013:... by Forouzanfar, M, Alexander, L, Anderson, H, Ali, R, Beardsley, J, Bennett, D, Briggs, A, Chen, Z, Gething, P, Jha, V, Moschandreas, J, Newton, C, Rahimi, K, Scarborough, P

“…<p><strong>Findings</strong></p> All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5–89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. …”

Fluorescent imaging and bio-cellular uptake assessment of gold-near infrared dye conjugated cockle shell calcium carbonate nanoparticles by Kiranda, H.K., Mahmud, R.B., Mahmood, S.K., Zakaria, Z.A.

“…Fluorescent imaging plays a critical role in molecular imaging. Evidence suggests its use in providing a detailed structural outlook and genetic and cellular operatives of the body procedures on a molecular plane. …”
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Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-... by Schumacher, AE, Kyu, HH, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, RJ, Bennett, D, Browne, AJ, Dolecek, C, Dunachie, SJ, Newton, CRJ, Rodriguez, JAB

“…An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). …”

Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets by Burchardt, JM, Mei, XW, Ranger, T, McDermott, CJ, Radunovic, A, Coupland, C, Hippisley-Cox, J

“…The use of national datasets may have captured additional MND patients with serious comorbidities who have not seen a neurologist before death. A limitation of this approach is that unlike population registers, which minimize false positive diagnosis by neurologist review of each patient, we cannot review diagnosis for individuals as data are anonymized.…”

External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland by Simpson, CR, Robertson, C, Kerr, S, Shi, T, Vasileiou, E, Moore, E, McCowan, C, Agrawal, U, Docherty, A, Mulholland, R, Murray, J, Ritchie, LD, McMenamin, J, Hippisley-Cox, J, Sheikh, A

“…<p><strong>Background</strong></p> The QCovid algorithm is a risk prediction tool that can be used to stratify individuals by risk of COVID-19 hospitalisation and mortality. …”