Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy by Dong, Shuming, Dong, Yushan, Liu, Bin, Liu, Jing, Liu, Shikai, Zhao, Zhiyu, Li, Wenting, Tian, Boshi, Zhao, Ruoxi, He, Fei, Gai, Shili, Xie, Ying, Yang, Piaoping, Zhao, Yanli

“…Elevated H2O2 is then exclusively catalyzed by the downstream POD-like activity of PHMZCO-AT to generate toxic hydroxyl radicals, further inducing tumor apoptosis and death. T1-weighted magnetic resonance imaging and high-contrast X-ray computed tomography imaging are also achieved using PEG/PHMZCO-AT nanozymes due to the existence of paramagnetic Mn2+ species and high X-ray attenuation ability of elemental Zr, permitting in vivo tracking of the therapeutic process. …”
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Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy by Peng, Boya, Nguyen, Trinh Mai, Jayasinghe, Migara Kavishka, Gao, Chang, Pham, Thach Tuan, Vu, Luyen Tien, Yeo, Eric Yew Meng, Yap, Gracemary, Wang, Lingzhi, Goh, Boon Cher, Tam, Wai Leong, Luo, Dahai, Le, Minh TN

“…However, delivery of 5' triphosphorylated RNA molecules as RIG-I agonists to tumour cells in vivo is challenging due to the susceptibility of these molecules to degradation. …”
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Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Vollset, SE, Ababneh, HS, Abate, YH, Lacey, BWH, GBD 2021 Forecasting Collaborators

“…That said, continued progress on reducing the CMNN disease burden will be dependent on maintaining investment in and policy emphasis on CMNN disease prevention and treatment. Mostly due to growth and ageing of populations, the number of deaths and DALYs due to all causes combined will generally increase. …”

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances by Lim, Hui Kheng, Hughes, Christopher Owen, Lim, Michelle Jing Sin, Li, Jia'En Jasmine, Rakshit, Moumita, Yeo, Calvin, Chng, Kern Rei, Li, Angela, Chan, Joanne Sheot Harn, Ng, Kee Woei, Leavesley, David Ian, Smith, Benjamin Paul Chapman

“…We are confident that the genotoxic response in the 3D microtissues more closely resembles the native tissues due to the inherent tissue architecture, surface area, barrier effects and tissue matrix interactions. …”
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Quantitative analysis of coronary artery from computed tomography angiography images by Cui, Hengfei

“…Coronary artery diseases (CAD) have been the major cause of death worldwide, accounting for about 17% of total US deaths. …”
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Antidiabetic activity of Curculigo latifolia extracts in vitro and in vivo studies by Ishak, Nur Akmal

“…The sweet taste of C. latifolia fruit is due to a protein known as curculin. This indicates that C.latifolia plant has the potential to be used as an alternative low-calorie sweetener for diabetic patients. …”
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Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-... by Schumacher, AE, Kyu, HH, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, RJ, Bennett, D, Browne, AJ, Dolecek, C, Dunachie, SJ, Newton, CRJ, Rodriguez, JAB

“…An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). …”

Computational Design And Synthesis Of Potential Ns2b-Ns3 Dengue Protease Inhibitors by Salin, Nurul Hanim

“…In week 6 of 2024, Malaysia reported with 3,631 dengue cases and 10 deaths due to DENV2, marking a 68.75 % increase from the same period in 2023, as reported by the World Health Organization (WHO). …”
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Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Steinmetz, JD, Seeher, KM, Schiess, N, Bennett, DA, Maude, RJ, Newton, CRJ, Rodriguez, JAB

“…We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. …”

Ultraviolet exposure and mortality among women in Sweden by Yang, L, Lof, M, Veierod, MB, Sandin, S, Adami, H-O, Weiderpass, E

“…</p> <p><strong>Results:</strong> During 15 years of follow-up, among the 38,472 women included in the present study, 754 deaths occurred: 457 due to cancer and 100 due to CVD. …”

Development of biomimetic 3D cancer platform for drug testing by Ker, Sia Fong

“…Cancer accounts for most of the deaths in the world and it is mainly due to metastasis that makes treatment of cancer difficult. …”
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In silico assessment of a compliant vascular prosthesis by Wong, Yi Jean

“…Coronary heart disease is one of the most common disease in the world causing about 30% of deaths per year. The main cause is resulted from the narrowing of blood vessels due to the accumulation of fatty material within a plaque on the inner walls of the coronary artery. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Influenza A virus (IAV) is a major public health problem responsible for the death of half a million people every year worldwide. …”
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Superior photocatalytic degradation of pharmaceuticals and antimicrobial Features of iron-doped zinc oxide sub-microparticles synthesized via laser-assisted chemical bath technique by Zyoud, Samer H., Che Abdullah, Che Azurahanim, Ashames, Akram, Hassan, Nageeb, Yahia, Ibrahim S., Zyoud, Ahed H., Zahran, Heba Y., Qamhieh, Naser, Makhadmeh, Ghaseb N., AlZoubi, Tariq

“…Predictions estimate up to 10 million annual deaths by 2050 due to antimicrobial resistance, underscoring the urgent need for innovative solutions. …”
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Aspects of the management of cheetahs, Acinonyx jubatus jubatus, trapped on Namibian farmlands by Marker, L, Dickman, AJ, Mills, M, Macdonald, D

“…The Namibian cheetah population has recently undergone serious decline due to human-mediated removals, and investigating the rates and causes of such removals is an important aspect of the future management of cheetah populations outside protected areas. …”

A study to minimize 'A'-pillar blind spot in cars by Choo, Daryl Gavin Jun Yan

“…Many of these accidents happen because drivers did not see the vulnerable road users. This is due to the presence of the A-pillar found in cars and its thickness has increased over the years. …”
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Investigations into high resolution imaging and contouring for diagnostic bio-applications by Valiyambath, Krishnan Mohankumar

“…As early detection is important to prevent deaths due to cancer, current emphasis is on periodic screening for persons over the age of 50. …”
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Exploring RNA interference for effective mosquito vector control by Govintharam Velu

“…They are considered to be deadly to humans due to their ability to spread such diseases rapidly and have caused large numbers of deaths worldwide. …”
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Discovery of exosomes as gastric cancer biomarkers from conditioned cell culture media. by Low, Su Jun.

“…Gastric cancer is the second leading cause of cancer-related deaths worldwide, largely due to frequent late diagnosis of the disease, since there are few efficient screening tests that can detect gastric cancer in its early stages. …”
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Global burden of Alzheimer’s disease and other dementias attributed to metabolic risks from 1990 to 2021: results from the global burden of disease study 2021 by Zhang, X, Guo, T, Zhang, Y, Jiao, M, Ji, L, Dong, Z, Li, H, Chen, S, Zheng, W, Jing, Q

“…Results: Globally, the count of AD and other dementia-related deaths due to metabolic risks grew from 98,608 to 399,824, a 4.1-fold increase. …”