Resistant hypertension and mortality: an observational cohort study by de la Sierra, A, Ruilope, LM, Staplin, N, Gorostidi, M, Vinyoles, E, Segura, J, Armario, P, Oliveras, A, Williams, B

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

“…We aimed to test whether high-titre CCP, administered early, is efficacious in preventing hospitalisation or death in high-risk patients.</p> <p><strong>Methods and analysis:</strong>&nbsp;COVIC-19 is a multicentre, randomised, open-label, adaptive superiority phase III trial comparing CCP with very high neutralising antibody titre administered within 7&thinsp;days of symptom onset plus standard of care versus standard of care alone. …”

DNA fragmentation, an indicator of apoptosis, in cultured black tiger shrimp penaeus monodon infected with white spot syndrome virus (WSSV) by Sahtout, A.H., Hassan, M.D., Shariff, M.

“…Given that DNA fragmentation is generally considered to be a hallmark of apoptosis, the results suggested that apoptosis might be implicated in shrimp death caused by WSSV.…”
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In vitro anti-cancer and antimicrobial effects of manganese oxide nanoparticles synthesized using Glycyrrhiza uralensis leaves extract on breast cancer cell lines by Althobiti, Maryam Musleh, Alzahrani, Badr, Elderdery, Abozer Y., Alzerwi, Nasser A. N., Rayzah, Musaed, Elkhalifa,, Ahmed M. E., Idrees, Bandar, Bakhsh, Ebtisam, Alabdulsalam, Abdulrahim A., Mohamedain, A., Kumar, Suresh S., Mok, Pooi Ling

“…The leaf extract of GU contains bioactive molecules that act as a reducing or capping agent to form Mn2O3 NPs. …”
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Large and unequal life expectancy declines during the COVID-19 pandemic in India in 2020 by Gupta, A, Hathi, P, Banaji, M, Gupta, P, Kashyap, R, Paikra, V, Sharma, K, Somanchi, A, Sudharsanan, N, Vyas, S

“…Compared to 2019, life expectancy at birth was 2.6 years lower and mortality was 17% higher in 2020, implying 1.19 million excess deaths in 2020. Life expectancy declines in India were larger and had a younger age profile than in high-income countries. …”

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study by Hamill, V, Wong, S, Benselin, J, Krajden, M, Hayes, PC, Mutimer, D, Yu, A, Dillon, JF, Gelson, W, Velásquez García, HA, Yeung, A, Johnson, P, Barclay, ST, Alvarez, M, Toyoda, H, Agarwal, K, Fraser, A, Bartlett, S, Aldersley, M, Bathgate, A, Binka, M, Richardson, P, Morling, JR, Ryder, SD, Barnes, E

Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden... by Bender, RG, Sirota, SB, Swetschinski, LR, Berkley, JA, Eyre, DW, McManigal, B, Pollard, AJ, Roberts, T, Runghien, T, Sartorius, B

“…From 2019 to 2021, during the COVID-19 pandemic and implementation of associated non-pharmaceutical interventions, we estimated a 16·0% (13·1–18·6) decline in the global all-age non-COVID-19 LRI mortality rate, largely accounted for by a 71·8% (63·8–78·9) decline in the number of influenza deaths and a 66·7% (56·6–75·3) decline in the number of RSV deaths. …”

Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets by Faustino, André F., Martins, Ivo C., Carvalho, Filomena A., Castanho, Miguel A. R. B., Maurer-Stroh, Sebastian, Santos, Nuno C.

“…Dengue virus (DENV) causes over 500,000 hospitalizations and 20,000 deaths worldwide every year. Dengue epidemics now reach temperate regions due to globalization of trade and travel and climate changes. …”
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相声剧中的反思议题 ：以《东厂仅一位》为例 = Topics in stand-up comedy : a case study on “The Last One of Ming dynasty” by 杨凯威 Yeong, Hoi Wai

“…Xiangsheng (commonly known as Crosstalk in English), a Chinese folk art performance originated in Beijing, China during the late Qing Dynasty, experience blooming and death in Taiwan. …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…YLLs were calculated by multiplying cause-age-sex-location-year-specific deaths by the standard life expectancy at the age that death occurred. …”

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…The alternative lengthening of telomeres (ALT) pathway is a telomerase-independent mechanism for immortalization in cancer cells and is commonly activated in low-grade and high-grade glioma, as well as osteosarcoma. …”

Mortality risks in different subtypes of masked hypertension in the Spanish ambulatory blood pressure monitoring registry by de la Sierra, A, Ruilope, LM, Staplin, N, Stergiou, GS, Williams, B

Understanding lived experiences of bereaved parents of children with chronic life-threatening Illness : towards a culture-specific and meaning-oriented narrative E-writing interven... by Dutta, Oindrila

“…It is a misconception that death occurs only in later life. …”
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Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the pre... by Tran-To Su, Chinh, Ouyang, Xuchang, Zheng, Jie, Kwoh, Chee Keong

“…Background: Since late March 2013, there has been another global health concern with a sudden wave of flu infections by a novel strain of avian influenza A (H7N9) virus in China. …”
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The UK Breast Cancer in Pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom:... by Hardy, C, Brand, A, Jones, J, Knight, M, Banfield, P

“…Although short-term outcomes were generally good for mothers and babies, a larger prospective study is required. It is often possible to avoid exposing the baby to iatrogenic prematurity.…”

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013:... by Forouzanfar, M, Alexander, L, Anderson, H, Ali, R, Beardsley, J, Bennett, D, Briggs, A, Chen, Z, Gething, P, Jha, V, Moschandreas, J, Newton, C, Rahimi, K, Scarborough, P

“…<p><strong>Findings</strong></p> All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5–89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. …”

Fluorescent imaging and bio-cellular uptake assessment of gold-near infrared dye conjugated cockle shell calcium carbonate nanoparticles by Kiranda, H.K., Mahmud, R.B., Mahmood, S.K., Zakaria, Z.A.

“…Fluorescent imaging plays a critical role in molecular imaging. Evidence suggests its use in providing a detailed structural outlook and genetic and cellular operatives of the body procedures on a molecular plane. …”
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Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets by Burchardt, JM, Mei, XW, Ranger, T, McDermott, CJ, Radunovic, A, Coupland, C, Hippisley-Cox, J

“…The use of national datasets may have captured additional MND patients with serious comorbidities who have not seen a neurologist before death. A limitation of this approach is that unlike population registers, which minimize false positive diagnosis by neurologist review of each patient, we cannot review diagnosis for individuals as data are anonymized.…”

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-... by Schumacher, AE, Kyu, HH, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, RJ, Bennett, D, Browne, AJ, Dolecek, C, Dunachie, SJ, Newton, CRJ, Rodriguez, JAB

“…Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. …”

External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland by Simpson, CR, Robertson, C, Kerr, S, Shi, T, Vasileiou, E, Moore, E, McCowan, C, Agrawal, U, Docherty, A, Mulholland, R, Murray, J, Ritchie, LD, McMenamin, J, Hippisley-Cox, J, Sheikh, A

“…<p><strong>Background</strong></p> The QCovid algorithm is a risk prediction tool that can be used to stratify individuals by risk of COVID-19 hospitalisation and mortality. …”