Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…In order to explore whether this feature may be present from the early stages of MS and may be associated with the clinical outcome, the protein levels of TNF, sTNF-R1 and sTNF-R2 were assayed in CSF collected from 122 treatment-naïve MS patients and 36 subjects with other neurological conditions at diagnosis. Potential correlations with other CSF cytokines/chemokines and with clinical and imaging parameters at diagnosis (T0) and after 2 years of follow-up (T24) were evaluated. …”
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Preclinical development of antisense conjugates for the treatment of myotonic dystrophy 1 by Stoodley, J

“…However, no therapy has yet been specifically developed that aims to additionally penetrate the CNS and treat the neurological symptoms experienced by patients. Furthermore, cell-penetrating peptide ASO conjugates (CPP-ASOs) can be associated with nephrotoxicity at higher doses, resulting in a trade-off between efficacy and toxicity, highlighting the need for further optimization to broaden their therapeutic window.…”

Opportunities and challenges in the sustainable integration of natural fibers and particles in friction materials for eco-friendly brake pads by Imran, Al Ichlas, Siregar, Januar Parlaungan, Mohd Ruzaimi, Mat Rejab, Cionita, Tezara, Hadi, Agung Efriyo, Jamiluddin, Jaafar, Fitriyana, Deni Fajar, Dewi, Rozanna

“…Moreover, eco-friendly brake pads are typically biodegradable, which helps reduce ecological damage, minimize health concerns for humans and animals, and promote a sustainable automobile sector. …”
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Phenotypic, physiological, and molecular response of Loropetalum chinense var. rubrum under different light quality treatments based on leaf color changes by Zhang, Yifan, Liu, Yang, Ling, Lin, Huo, Wenwen, Li, Yang, Xu, Lu, Xiang, Lili, Yang, Yujie, Xiong, Xingyao, Zhang, Donglin, Yu, Xiaoying, Li, Yanlin

“…This provides an effective ecological strategy for light-induced leaf-color changes, thereby promoting the ornamental and economic value of L. chinense var. rubrum.…”
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Quality assessment of acoustic environment reproduction methods for cinematic virtual reality in soundscape applications by Gan, Woon-Seng, Ooi, Kenneth, Kang, Jian, Feng, Jing, Hong, Joo Young, Lam, Bhan, Ong, Zhen-Ting, Tan, Sze-Tiong

“…It is therefore imperative to assess the quality of commonly used spatial audio reproduction methods to determine their ecological validity. Through subjective evaluations with 30 participants, the same participant evaluated four outdoor in situ locations vis-à-vis its corresponding audio-visual recording in VR on a separate day. …”
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Can green finance facilitate Industry 5.0 transition to achieve sustainability? A systematic review with future research directions by Dhayal, Karambir Singh, Giri, Arun Kumar, Kumar, Anil, Samadhiya, Ashutosh, Agrawal, Shruti, Agrawal, Rohit

“…I5.0 forms a symbiotic relationship with different aspects of Society 5.0 (S5.0) such as social (human‒machine centricity), ecological (zero emissions), and technological (green innovations). …”
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Characterization of Microbial Primary and Secondary Metabolism in the Marine Realm by Geller-McGrath, David Edward

“…This thesis applies meta-omics data analysis to elucidate the ecological roles of marine microorganisms in diverse habitats and includes the development of new bioinformatics tools to enhance these analyses. …”
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On the non-microbial sources and sinks of dissolved metabolites in seawater by Germolus, Noah Paul

“…Chapter 5 reflects on how metabolites break the microbial loop—and suture it together with more ecological richness than with elemental fluxes alone.…”
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More than just a show: extending the impact of museum exhibitions for good by Salter, Kerryn Elizabeth

“…As a result, increasingly and more vociferously, there are calls for museums to be accountable, to address these systemic and institutionally embedded issues, and to be a proactive player and force for good in engaging audiences in broader social, political, economic, and ecological issues, in ways that provoke curiosity, criticality, and dialogue. …”
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Intersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya’s ASAL: A qualitative study by Chongwo, EJ, Aoko, B, Kaniala, M, Esala, M, Magoma, P, Njoroge, E, Nyamanya, S, Marangu, J, Khamis, A, Ng’asike, J, Huizink, AC, Abubakar, A

“…The findings, viewed through the lens of Bronfenbrenner’s ecological systems theory, reveal a complex interplay of contextual factors impacting children’s development. …”

Mitigating marine megafauna captures in fisheries by Arlidge, W

“…The decision-making processes I employ include qualitative ecological risk assessment theory to assess the efficacy of current management systems, and a qualitative management strategy evaluation process to support consideration of trade-offs. …”

Complex mosaic landscapes: novel methodologies to understand dynamics of cocoa farming in Ghana by Moore, C

“…The later part of the thesis focuses on the dynamics and processes which govern complex mosaic landscapes by framing them as social-ecological systems. The second data chapter provides a detailed summary of land use in the area of study while also quantifying the impact of humans on the environment by calculating and comparing the Human Appropriated Net Primary Productivity between the three study regions. …”

Molecular detection, risk factor and public awareness of avian bornavirus from captive and non-captive birds in Peninsular Malaysia by Mohd Lutpi, Syamsiah

“…Birds with PDD may show signs of gastrointestinal tract deficit (e.g., weight loss, regurgitation, passage of undigested food in faeces), or neurological dysfunction (e.g., ataxia, abnormal gait, proprioceptive defects) or even both. …”
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Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…Proper mRNA localisation is vital for the correct functioning of the entirety of a glial cell and dysregulation of mRNA localisation in glial cells has been implicated in neurodegenerative and neurological diseases and some types of cancer. Therefore, gaining a deeper understanding of the mechanisms that mediate mRNA localisation is of paramount value.…”

Genetic analysis of normal human phenotypes within the people of the British Isles by Meena, D

“…</p> <p>The last part of this thesis provides new insights into the field of olfactory perception and argues for the potential link between neurological disorders and olfactory impairment. Most, if not all, novel variants (suggestive genome-wide significant) presented in this research have strong functional biological support behind the preliminary statistical observations and will be helpful in understanding the visible pigmentation differences among humans as well as the genetics underlying food preferences.…”

Assessing the role of internal phosphorus recycling on eutrophication in four lakes in China and Malaysia by Tay, Chai Jian, Koh, Hock Lye, Mohd Hafiz, Mohd, Teh, Su Yean

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发展环保NGO推进资源型城市污水处理 ：以黑龙江省鸡西市污水处理研究为例 = Develop environmental NGOs to enhance the treatment of polluted water in resource-based cities : a case study of Jixi city, Heilongjiang prov... by 陈青 Chen, Qing, 李培生 Li, Peisheng, 王治洋 Wang, Zhiyang, 孙连富 Sun, Lianfu

“…Jixi existing sewage treatment model in resource-based representative of the city, its very obvious shortcomings, the main problems: the lack of external pressure, the Government's emphasis on environmental issues is inadequate; the limited financial resources, the government itself can not provide the city needs Environmental public goods; Since we can not properly handle the economic development and ecological environmental protection interests, businesses and residents on waste water treatment monitoring, oversight.…”
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Childlessness and its associated factors among Chinese women: a nationwide population-based study by Han, Q, Dang, J, Wu, Y, Ye, W

“…Logistic and linear regression analyses were conducted to examine factors associated with childlessness among reproductive-aged and post-reproductive women, and reproductive anxiety among childless women of reproductive age at intrapersonal, interpersonal, and societal levels, as outlined in the social-ecological model. Results: The comparison of reproductive patterns among women across different age groups showed a dramatic decline in the proportion of having three or more children, and a gradual increase in the childlessness over time. …”

Life cycle assessment of greenhouse gas emissions and carbon mitigation methods in probiotic-fed broiler production by Chin, H.W., Tee, T.P., Tan, N.P., Angkanaporn, Kris

“…Implementing sustainable agricultural practices could lead to more ecological poultry production, contributing to global efforts in climate change mitigation.…”

Recent use of AB mix nutrients for urban farming in Malaysia: a mini review by Sanusi, Nur Dinie Syahirah, Ros, Fadhlina Che, Demon, Siti Zulaikha Ngah, Ismail, Ismayadi, Hamadneh, Imad

“…The increasing adoption of AB mix nutrients aligns with the demand for efficient urban farming methods, but it also brings into focus the critical balance between maximizing crop yield and minimizing ecological damage. This review emphasizes the significance of controlled nutrient application to prevent long-term soil degradation and groundwater contamination. …”
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