Showing 721 - 740 results of 5,993 for search '((espinal OR (spinae OR find)) OR ((((ping OR wings) OR shen) OR sspina) OR pin))', query time: 0.22s Refine Results
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    The α-globin super-enhancer acts in an orientation-dependent manner by Kassouf, MT, Francis, HS, Gosden, M, Suciu, MC, Downes, DJ, Harrold, C, Larke, M, Oudelaar, M, Cornell, L, Blayney, J, Telenius, J, Xella, B, Shen, Y, Sousos, N, Sharpe, JA, Sloane-Stanley, J, Smith, AJH, Babbs, C, Hughes, JR, Higgs, DR

    Published 2025
    “…When the SE is inverted within its normal chromosomal context, expression of its normal targets, the α-globin genes, is severely reduced and the normally silent genes lying upstream of the α-globin locus are upregulated. These findings add to our understanding of enhancer-promoter specificity that precisely activate transcription.…”
    Journal article
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