Simultaneous polymerization and adhesion under hypoxia in sickle cell disease by Papageorgiou, Dimitrios P., Abidi, Sabia Z., Chang, Hung-Yu, Li, Xuejin, Kato, Gregory J., Karniadakis, George E., Suresh, Subra, Dao, Ming

“…We show that (i) hypoxia significantly enhances sickle RBC adherence; (ii) HbS polymerization enhances sickle cell adherence in SRs and SMEs, but not in ISCs; (iii) SRs exhibit unique adhesion dynamics where HbS fiber projections growing outward from the cell surface create multiple sites of adhesion; and (iv) polymerization stimulates adhesion and vice versa, thereby establishing the bidirectional coupling between the two processes. These findings offer insights into possible mechanistic pathways leading to vasoocclusion crisis. …”
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Experimental and computational thermal analysis of vortex flame in meso-scale combustor by Khaleghi, Mostafa

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Intelligent diagnostic feedback in virtual learning environment by Guo, Ruisheng

“…Severaltrialsare conducted inorderto evaluate theapproach and the system. The findings are analyzed and lead to the conclusion that under certain conditions online diagnostic feedback is an effective means of enhancing student learning across a wide range of subject.…”
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A discourse analysis looking at the way counselling psychologists discuss and address issues of race with individuals from black Asian and minority ethnicities by Madre de Deus de Sousa, Filipe Alexandre

“…The first two discourses alluded to similar repertoires present in the discourses of white counselling psychologist participants whereas the discourse challenging systemic racism was mainly constructed by BAME counselling psychologists. Conclusion: The findings suggested that the discourses counselling psychologists used to address issues of race and the impact of difference, when engaging with BAME individuals, appeared to be associated to the racial identity of the practitioner. …”
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Water quality prediction and carbon reduction mechanisms in wastewater treatment in Northwest cities using Random Forest Regression model by Sun, Jingjing, Guan, Xin, Sun, Xiaojun, Cao, Xiaojing, Tan, Yepei, Liao, Jiarong

“…This work provides critical support for optimizing wastewater treatment technologies and developing water resource management policies. These findings also offer essential theoretical and empirical insights for the future improvement of urban wastewater treatment technologies and water resource management decision-making.…”
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Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by de Oliveira-Souza, AIS, Barbosa-Silva, J, Gross, DP, da Costa, BR, Ballenberger, N, Pereira, TV, Dennett, L, Armijo-Olivo, S

“…NMAs will be conducted to rank interventions according to their effectiveness and safety (when possible), allowing a comprehensive analysis of all available evidence, with different nodes specified for all conservative interventions of interest, placebo, sham therapy, and non-intervention control. Major findings/summary of interpretations/conclusions: This NMA will help clinicians and the scientific community choose the most effective strategy or combinations of strategies for treating neck pain. …”

Investigation into ion channel- and nitric oxide-mediated vasodilation in resistance arteries by Wallis, LE

“…</p> <br> <p>Overall, these findings enhance our understanding of microvascular function and provide a basis for further research which may have significant clinical implications.…”

The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…</p> <p>Contrary to its previously reported inhibitory effects on osteoblastogenesis, this thesis shows, for the first time, that TSG-6 displays context-specific anabolic properties. This finding implies a therapeutic value for the protein, with possibilities of being used in conjunction with BMP-2 to treat local bone injuries such as fractures.…”

Effect of intra-articular corticosteroid injections for osteoarthritis on the subsequent use of pain medications: a UK CPRD cohort study by Hawley, S, Prats Uribe, A, Matharu, GS, Delmestri, A, Prieto Alhambra, D, Judge, A, Whitehouse, MR

“…</p> <br> <p><strong>Conclusions:</strong> IACI for knee or hand osteoarthritis showed lower incidence of several pain medications over the longer-term relative to no IACI use. Secondary findings suggest IACI may be effective in reducing longer-term use of opioid-nonopioid analgesic combinations for patients with knee, hip, hand, or shoulder osteoarthritis.…”

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Liu, D, Wang, N, Song, M, Chai, X, He, Q, Cao, T, Kong, D, Song, Z, Zhang, G, Liu, L, Wang, X, Chen, G, Yin, S, Yang, Y, Zhao, J

“…The best classification rate in the derivation cohort was achieved at a metabolic index of 3.32 (41% of the mean cortical metabolic index in healthy controls). Conclusion: Our findings demonstrate that conscious awareness requires a minimum of 41% of normal cortical activity, as indicated by metabolic rates.…”

The impact of psoriatic arthritis on quality of life: a systematic review by James, L, Hailey, L, Suribhatia, R, McGagh, D, Amarnani, R, Bundy, C, Kirtley, S, O'Sullivan, D, Steinkoenig, I, White, J, Vivekanantham, A, Coates, LC

“…</p> <br> <p><strong>Results:</strong> The study included 37 comprehensive studies that examined the impact of PsA on QoL and physical function. The findings revealed that the impact of PsA extends to various aspects of life, including activities of daily living, physical, and emotional aspects, such as fatigue, sleep disturbance, anxiety and depression. …”

Content learning in Japanese and English medium instruction: comparing chemistry learning outcomes in Japanese higher education by Aizawa, I

“…The study found that while the quantitative findings unveiled no differences in content learning outcomes according to the medium of instruction, the qualitative evidence revealed that EMI students encountered a greater level of challenges than their JMI counterparts. …”

Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory by Faizy, TD, Yedavalli, V, Salim, HA, Lakhani, DA, Musmar, B, Adeeb, N, Essibayi, MA, Daraghma, M, El Naamani, K, Henninger, N, Sundararajan, SH, Kuhn, AL, Khalife, J, Ghozy, S, Scarcia, L, Yeo, LL, Tan, BY, Regenhardt, RW, Heit, JJ, Cancelliere, NM, Rouchaud, A, Fiehler, J, Sheth, SA, Puri, AS, Dmytriw, AA

“…Conclusion: Unsuccessful MT for MeVO was linked to worse outcomes than best MM. These findings highlight the risks of prolonged attempts and emphasize the importance of efficient procedural decision-making to reduce complications and improve patient outcomes.…”

Exploring effects of calcitonin and procalcitonin in cardiomyocytes by Moreira, LMF

“…In contrast, I have not observed any evidence of PCT binding to CTRs, but instead uncovered, through PCT interactome studies, a previously unknown direct interaction of PCT with a subunit of L-type calcium channel, LTCC (α2δ3), which was also associated with a decrease in ERK1/2 phosphorylation.</p> <p>These findings suggest that CT and PCT exert opposite effects on the function of atrial CMs. …”

Combining detection dogs and camera traps improves minimally-invasive population monitoring for the cheetah, an elusive and rare large carnivore by Verschueren, S, Hofmann, T, Schmidt-Küntzel, A, Kakove, M, Munyandi, B, Bauer, H, Balkenhol, N, Leirs, H, Neumann, S, Cristescu, B, Marker, L

“…We showed that complementing detection dog surveys with camera trapping can comprehensively and efficiently inform occurrence patterns for an exceptionally wide-ranging terrestrial carnivore. Our findings provide practical guidance for designing effective minimally-invasive monitoring programs, which are important for empirically deriving distribution maps of cheetahs and other carnivores in data-poor regions.…”

Exploring population structure, antibiotic resistance and horizontal gene transfer in Neisseria gonorrhoeae by Unitt, A

“…</p> <p>Together, these results provide an improved understanding of <em>N. gonorrhoeae</em> genetics with implications for public health: informing efforts to survey and suppress the evolution of resistance inducing mosaic <em>penA</em> alleles, and describing how gonococcal population structure relates to features such as geographical location and antibiotic resistance, while providing a publicly available lineage nomenclature for future analyses. These findings highlight the advantages of using population-level analysis of bacterial whole genome sequence data to reveal new facets of pathogen biology.…”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Gomez Fernandez, L, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, S, Patil, K, Gairola, S, Dunachie, S, Merchant, H, Stokes, R, Kuwana, R, Maes, A, Charrier, J-P, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, P, Zitzmann, N, Gangadharan, B

“…Furthermore, even if a falsified product contained polysorbate 80 at the same concentration as used in the genuine vaccine, the characteristic spectral profile of polysorbate 80 used in genuine products is a reliable internal marker for vaccine authenticity. Our findings demonstrate that MALDI-ToF MS analysis of extracts from vial labels and the vaccine excipients themselves can be used independently to detect falsified vaccines. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…However, the majority of the present findings are based on linear cascade or low-speed rotational studies, due to the high cost of the experiments and difficulty in instrumentation at engine conditions. …”

Intersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya’s ASAL: A qualitative study by Chongwo, EJ, Aoko, B, Kaniala, M, Esala, M, Magoma, P, Njoroge, E, Nyamanya, S, Marangu, J, Khamis, A, Ng’asike, J, Huizink, AC, Abubakar, A

“…Results: The mean age of the participants was 44years (SD = 11 years). The findings, viewed through the lens of Bronfenbrenner’s ecological systems theory, reveal a complex interplay of contextual factors impacting children’s development. …”

Technology integration in newborn care: examining communication and decision-making among health professionals in Kenyan hospitals by Ngaiza, GK

“…Combining inductive and deductive coding, the thematic data analysis identified key themes and built explanations.</p> <p>Findings reveal that physical context elements, such as adequate staffing, patient rooms in close proximity and health professionals’ communal congregation area promote more frequent and in-depth communication among health professionals using CPAP and phototherapy. …”