DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts by Kuś, K, Carrique, L, Kecman, T, Fournier, M, Hassanein, SS, Aydin, E, Kilchert, C, Grimes, JM, Vasiljeva, L

Fluorescence techniques used to measure interactions between hydroxyapatite nanoparticles and epidermal growth factor receptors by Kathawala, Mustafa H., Khoo, Stella P. K., Sudhaharan, Thankiah, Zhao, Xinxin, Loo, Joachim Say Chye, Ahmed, Sohail, Ng, Kee Woei

“…To examine the interaction between nanoparticles and cell membrane receptors, this report describes the use of advanced fluorescence techniques to measure interactions between hydroxyapatite (HA) nanoparticles and epidermal growth factor receptors (EGFRs), as a model system. FITC-labelled HA nanoparticles and monomeric red fluorescent protein (mRFP)-conjugated EGFRs expressed in Chinese hamster ovary cells (CHO-K1) were generated and their interaction measured using acceptor photobleaching-fluorescence resonance energy transfer (AP-FRET) and fluorescence lifetime imaging microscopy-fluorescence resonance energy transfer (FLIM-FRET). …”
Get full text
Get full text

Sig2GRN : a software tool linking signaling pathway with gene regulatory network for dynamic simulation by Zhang, Fan, Liu, Runsheng, Zheng, Jie

Get full text
Get full text

Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells by Xing, X., Huang, L., Li, X., Li, Z., Zhou, W., Tian, L., Chen, J., Chen, C., Ma, Xing, Yang, Z.

“…Our previous studies have shown that the inhibition of phosphatidylinositol 3-kinase (PI3K) or mTOR complex 1 can obviously promote the Coxsackievirus B3 (CVB3)-induced apoptosis of HeLa cells by regulating the expression of proapoptotic factors. …”
Get full text
Get full text

A critical review on the moderating role of contextual factors in the associations between video gaming and well-being by Hartanto, Andree, Lua, Verity Y. Q., Quek, Frosch Y. X., Yong, Jose C., Ng, Matthew H. S.

Get full text

Design and development of an interactive design tutor by Wong, Cyprian Cin Howe.

Get full text

Affective-cognitive design of product ecosystems for user experience by Zhou, Feng

“…Although companies have long been concerned with users in the product design and development process, the emphasis has been on the cognitive aspects to support users’ cognitive processes through human-product interactions, demonstrated as usability studies in the areas of human factors and human-computer interaction. Further, traditional usability studies often consider interactions between the user and a single object (product), ignoring the kind of user interactions in a context of product ecosystems that consist of multiple interdependent products, users, and ambient factors (e.g., environmental settings and cultural factors). …”
Get full text

Hand motion detection by Pan, Bentrium Jin Jian

Get full text

CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment by Greensmith, Robert, Lape, Isadora T., Riella, Cristian V., Schubert, Alexander J., Metzger, Jakob J., Dighe, Anand S., Tan, Xiao, Hemmer, Bernhard, Rau, Josefine, Wendlinger, Sarah, Diederich, Nora, Schütz, Anja, Riella, Leonardo V.

“…Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. …”
Get full text

YAP-DKK1 axis restricts regeneration to the isthmus of the human gastric glands by Zagami, C

“…Interestingly, DKK1 expression was found to spatially correlate with and be regulated by YAP, a key coactivator acting via binding to the TEAD transcription factor of the mechano-sensing Hippo pathway.…”

Characterising the functional role of GATA1short isoform in normal and malignant haematopoiesis by Cruz Hernandez, D

“…Both TAM and ML-DS are driven by mutations in the gene encoding the X-linked erythroid-megakaryocyte transcription factor GATA1 that result in truncation of 83 N-terminal amino acids to produce GATA1short (GATA1s). …”

Transcriptional regulation of type I interferon responses of myeloid antigen presenting cells by Sin, Wei Xiang

“…The transcription factor IRF7 is thought to be primarily involved in the regulation of type I IFN responses in viral infections. …”
Get full text

Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…In addition, studies in S. pombe have assigned a novel signalling function for Ofd1 in the regulation of sterol response genes via the Sre1 transcription factor. …”

Link me baby one more time: social music discovery on Spotify by Babul, SA, Hristova, D, Lima, A, Lambiotte, R, Beguerisse-Díaz, M

“…We explore the social and contextual factors that influence the outcome of person-to-person music recommendations and discovery. …”

Are privately owned shipping companies more succesful than public listed ones? by Zhang, Allen Tongren

Get full text

Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking by Voorhies, Kirsten, Young, Kendra, Hsu, Fang-Chi, Palmer, Nicholette D., McDonald, Merry-Lynn N., Lee, Sanghun, Hahn, Georg, Hecker, Julian, Prokopenko, Dmitry, Wu, Ann Chen, Regan, Elizabeth A., DeMeo, Dawn, Kinney, Greg L., Crapo, James D., Cho, Michael H., Silverman, Edwin K., Lange, Christoph, Budoff, Matthew J., Hokanson, John E., Lutz, Sharon M.

“…Results: We identified genome-wide significant associations for CAC in the chromosome 9p21 region [CDKN2B-AS1] among all COPDGene participants (p = 7.1 × 10−14) and among males (p = 1.0 × 10−9), but the signal was not genome-wide significant among females (p = 6.4 × 10−6). …”
Get full text

Individual, clinical and system factors associated with the place of death : a linked national database study by Tan, Woan Shin, Bajpai, Ram, Low, Chan Kee, Ho, Andy Hau Yan, Wu, Huei Yaw, Car, Josip

“…Factors associated with home death included being 85 years old or older (OR 4.45, 95% CI 3.55–5.59), being female (OR 1.21, 95% CI 1.16–1.25), and belonging to Malay ethnicity (OR 1.91, 95% CI 1.82–2.01). …”
Get full text
Get full text
Get full text

Childlessness and its associated factors among Chinese women: a nationwide population-based study by Han, Q, Dang, J, Wu, Y, Ye, W

“…Higher education level (OR = 2.83 [2.26, 3.55]; OR = 2.35 [1.44, 3.74]), being the only child in the family (OR = 2.85 [2.28, 3.55]; OR = 10.56 [7.38, 15.14]), and exposure to intimate partner violence (OR = 1.15 [1.02, 1.29]; OR = 1.68 [1.43, 1.98]) were significantly associated with childlessness among both reproductive-aged women and post-reproductive women. …”

A proposed framework of research on the influencing factors of burnout-based on the perspective of individual work scenarios by Lu, Guangguo, Kanjanapathy, Malini, Mohamed Saat, Maisarah

Get full text

Environmental risk factors for self-harm during imprisonment: A pilot prospective cohort study by Stephenson, T, Harris, I, Armstrong, C, Fazel, S, Short, R, Blackwood, N

“…Single cell placement (OR 4.31, 95% CI 1.06–18.24, p = 0.041) and more frequent changes of cellmate (OR 1.52, CI 1.14–2.17, p = 0.009) and cell (OR 1.83, 95% CI 1.28–2.86, p = 0.003) were associated with an increased risk of self-harming behaviour. …”