Different modes of regulation govern miRNA expression levels in Drosophila melanogaster by Lim, Mandy Yu Theng

“…Loquacious (Loqs) is a dsRNA-binding protein that binds Dicer-1 to cleave pre-miRNAs into short duplexes. …”
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Protective Capacity of the Human Anamnestic Antibody Response during Acute Dengue Virus Infection by Xu, Meihui, Züst, Roland, Toh, Ying Xiu, Pfaff, Jennifer M., Kahle, Kristen M., Davidson, Edgar, Doranz, Benjamin J., Velumani, Sumathy, Tukijan, Farhana, Wang, Cheng-I, Fink, Katja

“…Half of the world's population is exposed to the risk of dengue virus infection. …”
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Membrane reconstitution of monoamine oxidase enzymes on supported lipid bilayers by Wang, Liulin, Kabir H. Biswas, Yoon, Bo Kyeong, Kawakami, Lisa M., Park, Soohyun, Groves, Jay T., Li, Lin, Huang, Wei, Cho, Nam-Joon

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Bifunctional diazirine reagent for covalent dyeing of Kevlar and inert polymer materials by Liu, Richard Y., Luo, Shao-Xiong Lennon, Hirst, Elizabeth S., Doona, Christopher J., Swager, Timothy M.

“…The reagent's structure features a trifluoromethyl diazirine group as a precursor to a carbene that binds the textile surface. On the reagent's other terminus, a benzyl bromide group acts as a site accessible for substitution reactions. …”
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Unconventional split aptamers cleaved at functionally essential sites preserve biorecognition capability by Wang, Ruoyu, Zhang, Qiansen, Zhang, Yi, Shi, Hanchang, Nguyen, Kim Truc, Zhou, Xiaohong

“…An allosteric binding mechanism of BPSPAs, in which a new binding pocket is formed upon the target binding, is revealed by all-atom microsecond-scale molecular dynamics simulations. …”
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Structure of the C-terminal domain of the multifunctional ICP27 protein from herpes simplex virus 1 by Nordlund, Par, Patel, Vidhi, Dahlroth, Sue-Li, Rajakannan, Venkatachalam, Ho, Hai Ting, Cornvik, Tobias

“…The structure reveals the C-terminal half of ICP27 to have a novel fold consisting of -helices and long loops, along with a unique CHCC-type of zinc-binding motif. …”
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Part I Targeting RNA duplexes with modified triplex-forming oligonucleotides Part II Allostery within a Watson-Crick RNA duplex and its application in studying RNA recognition by R... by Zhou, Yuan

“…Here, we incorporated Locked Nucleic Acid (LNA), 2-thio U, and 2′-O methyl modified residues in a series of all pyrimidine RNA TFOs, and studied the binding to two RNA hairpin structures. 12-Base-triple major-groove pyrimidine•purine-pyrimidine triplex structures form between the RNA/DNA hairpins and the complementary RNA TFOs. …”
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Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide by Meher, Geetanjali, Bhattacharjya, Surajit, Chakraborty, Hirak

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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. …”
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Resonance modes of tall plasmonic nanostructures and their applications for biosensing by Soehartono, Alana M., Tobing, Landobasa Y. M., Mueller, Aaron D., Yong, Ken-Tye, Zhang, Dao Hua

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Effects of condensed tannin fractions from Leucaena leucocephala (LAM.) De wit hybrid on methane mitigation, rumen fermentation and diversity of methanogens, protozoa and bacteria... by Mookiah, Saminathan

“…The b values representing the CT quantities needed to bind half of the maximum precipitable bovine serum albumin increased with decreasing MWs from fraction F1 to fraction F5, with values of 0.216, 0.295, 0.359, 0.425, and 0.460, respectively. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…The last two decades have seen an increasing demand for new protein-modification methods from the biotech industry and biomedical research communities. Owing to their mild aqueous reaction conditions, enzymatic methods based on the use of peptide ligases are particularly desirable. …”
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Macrobrachium rosenbergii De Man nodavirus recombinant capsid protein production and its interactions with RNA by Goh, Zee Hong

“…Studies on the other members of the Nodaviridae family revealed that the RNA binding site is important for virus assembly and removal of this region inhibits the virus maturation. …”
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Methyl and dimethyl o-xylenyl-substituted fullerene acceptors for polymer solar cells by Kim, Hee Un, Park, Jong Baek, Grimsdale, Andrew Clive, Hwang, Do-Hoon

“…These values correlate with the binding affinities of the fluorophore and quencher. …”
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Synthesis and application of peptidoglycan oligomers as metabolic labeling agents for bacteria by He, Jingxi

“…Using super-resolution STED confocal microscopy, PGO-rhodamine were found to be localized into the cell walls of all bacterial strains tested. Furthermore, the PGO-rhodamine was not taken up or incorporated into mammalian cells at all, thus confirming that PGOs can be a powerful tool for pan-bacteria-specific labeling and imaging. …”
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Use of peptide asparginyl ligases (PALs) in generating alternative non-Ig protein-drug conjugates for cancer therapy by See, Julia Jing Yi

“…Due to challenges regarding limited time constraints and unforeseen power outage, future investigation to assess Affibody & DARPin binding affinity (Kd) and half-maximal inhibitory concentration (IC50) to unravel further insights into non-Ig proteins with enzymatic ligation for therapeutic applications.…”
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In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus by Nagarajan, Nagasundaram, Yapp, Edward Kien Yee, Le, Nguyen Quoc Khanh, Yeh, Hui-Yuan

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Hodge theory and its applications to molecular data analysis by Koh, Ronald Joon Wei

“…Nevertheless, there are currently many methods to call TADs, all of which are not based on a rigorous topological mathematical model. …”
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Structure and functions of a metallo-beta-lactamase- like hypothetical protein bleg1_2437 from alkali-tolerant soil bacterium Bacillus lehensis G1 by Tan, Soo Huei

“…Although MBL is not ubiquitously found in all pathogenic bacteria, its presence is a public health concern. …”
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