An epigenetic analysis of planarian stem cells by Dattani, A

“…<p>Planarian flatworms possess somatic pluripotent stem cells, called neoblasts (NBs), which are able to differentiate into all cell types that constitute the adult body plan. …”

Stem cell genome-to-systems biology by Chia, Na Yu, Ng, Huck-Hui

“…This allows for the determination of the molecular constituents that govern stem cell characteristics and conjointly with functional validations via genetic perturbation and protein location binding analysis necessitate the construction of the complex transcriptional regulatory network. …”
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Linking dual mode of action of host defense antimicrobial peptide thanatin: structures, lipopolysaccharide and LptAm binding of designed analogs by Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Sperandeo, Paola, Polissi, Alessandra, Bhattacharjya, Surajit

“…As a mode of bacterial cell killing, thanatin disrupts LPS outer membrane and inhibits LPS transport by binding to the periplasmic protein LptAm. …”
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Impact of molecular linker size on physicochemical properties of assembled gold nanoparticle mono-/multi-layers and their applicability for functional binding of biomolecules by Krikstolaityte, Vida, Hamit-Eminovski, Jildiz, Abariute, Laura, Niaura, Gediminas, Meskys, Rolandas, Arnebrant, Thomas, Lisak, Grzegorz, Ruzgas, Tautgirdas

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Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…The reticulon family of integral membrane proteins are conserved across all eukaryotes and typically localize to the endoplasmic reticulum (ER), where they are involved in generating highly-curved tubules. …”
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Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses by Scheim, David E., Parry, Peter I., Rabbolini, David J., Aldous, Colleen, Yagisawa, Morimasa, Clancy, Robert, Borody, Thomas J., Hoy, Wendy E.

“…Consistent with the biochemistry of coronaviruses as well established over decades, SARS-CoV-2 makes its initial attachment to host cells through the binding of its spike protein (SP) to sialylated glycans (containing the monosaccharide sialic acid) on the cell surface. …”
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The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response by Kim, Susana Soo-Yeon, Sze, Lynette, Lam, Kong-Peng

“…Confocal microscopy studies also show G3BP1 co-localization with RIG-I and with infecting vesicular stomatitis virus in Cos-7 cells. Interestingly, immunoprecipitation studies using biotin-labeled viral dsRNA or poly(I·C) and cell lysate–derived or in vitro translated G3BP1 indicated that G3BP1 could directly bind these substrates and again via its RGG domain. …”
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A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication by Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.

“…We show that DENV2 NS5 arginine 888, located within the carboxy-terminal 18 residues, is completely conserved in all flaviviruses and interacts specifically with the top-loop of 3'SL in the 3'UTR which contains the pentanucleotide 5'-CACAG-3' previously shown to be critical for flavivirus RNA replication. …”
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Force transduction through the bacterial cell envelope by Williams-Jones, D

“…I also examine the cell-wide implications of reducing TolA function in such a manner, with respect to membrane stability and cell division (chapter three). …”

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…In response to oxidative stress, but not ER stress, GADD34 recruited TDP-43, and enhanced cytoplasmic distribution and cysteine modifications of TDP-43 promoted its binding to GADD34. Arsenite also recruited a TDP-43 kinase, casein kinase-1ϵ (CK1ϵ), to GADD34. …”
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Soy-derived phytochemical genistein modifies chromatome topology to restrict cancer cell proliferation by Dutta, Bamaprasad, Park, Jung Eun, Qing, Ivan Toh Yi, Kon, Oi Lian, Sze, Siu Kwan

“…After exposure to low-dose genistein for >1 month, MDA-MB-231 cells exhibited stable epigenetic alterations that are analyzed via partial MNase digestion and TMT-based quantitative proteomics. 3177 chromatin-bound proteins are identified with high confidence, including 882 molecules that displayed altered binding topology after cell conditioning with genistein. …”
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Targeted pancreatic beta cell imaging for early diagnosis by Cong, Goh Zheng, Ghosh, Krishna Kanta, Mishra, Sachin, Gulyás, Miklós, Kovács, Tibor, Máthé, Domokos, Padmanabhan, Parasuraman, Gulyás, Balázs

“…The path for successful pancreatic beta cell imaging is fraught with challenges like non-specific binding, lack of beta cell-restricted targets, the requirement of probes to cross multiple lipid layers to bind to intracellular insulin. …”
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Towards high efficiency thin film solar cells by Han, Guifang, Zhang, Sam, Boix, Pablo P., Wong, Lydia Helena, Sun, Lidong, Lien, Shui-Yang

“…The emerging organic-inorganic halide perovskite systems, as well as the rapidly developed polycrystalline inorganic systems, organic photovoltaics and amorphous silicon cells are discussed in details. The biggest bottleneck for the cost-effective polycrystalline inorganic cells is the composition sensitivity and deep defects; for amorphous silicon cells, it is the quantum of the dangling bonds; for organic cells, it is the low charge carrier mobility and high exciton binding energy; and for perovskite cells, it is the environmental degradation and the controversial mechanisms of generation of I-V hysteresis. …”
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Design and Construction of Artificial Extracellular Matrix (aECM) Proteins from Escherichia coli for Skin Tissue Engineering by Low, Pearlie Si Jia, Tjin, Monica Suryana, Fong, Eileen

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In vivo visualization of cells with fluorescent-labeled fab fragment. by Wee, Armanda Lixuan.

“…This includes the expensive and tedious process to generate fluorescent reporter mice, as well as the immunogenicity of fluorescent-labeled antibodies mediated by Fc receptor binding. Therefore in this study, we generated fluorescent-labeled Fab fragments and evaluated their use in cells for in vivo imaging. …”
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Induction of z-conformation in ribosomal RNA by Z-DNA binding domain Zα of the human double-stranded RNA deaminase I (ADAR1) by Zhao, Jing

“…Recently our collaborators have discovered that ZαADAR1 binds stably to ribosomes inside E. coli and human cells leading to translational inhibition in vitro and in vivo (Feng, Li et al. 2011). …”
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Controlling the assembly of proteins and cells on SiO₂ surfaces by Seong, Jiehyun, 1973-

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Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog by Krishna, Manchugondanahalli Shivakumar, Toh, Desiree-Faye Kaixin, Meng, Zhenyu, Ong, Alan Ann Lerk, Wang, Zhenzhang, Lu, Yunpeng, Xia, Kelin, Prabakaran, Mookkan, Chen, Gang

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Elucidation of functional significance of plasmodium falciparum reticulocyte binding like protein homologues - RH1, RH2A AND RH4 during merozoite invasion. by Karthigayan Gunalan.

“…The successful invasion of Plasmodium falciparum depends on the recognition of host cell receptors by parasite ligands. One major family of ligands involved in these interactions is the Reticulocyte binding like protein Homologues (RHs). …”
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Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,... by Yang, Z, Sheehan, AM, Messer, AE, Tsui, S, Sparrow, A, Redwood, C, Kren, V, Gould, IR, Marston, SB

“…Results: Silybin B, EGCG and resveratrol restored the phosphorylation-induced change in molecular dynamics to wild-type values, whilst silybin A, an inactive isomer of silybin B, and Epicatechin gallate, an EGCG analogue that does not recouple, did not. …”