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Biotin-streptavidin binding interactions of dielectric filled silicon bulk acoustic resonators for smart label-free biochemical sensor applications
Published 2014“…Sensor performance of a dielectric filled silicon bulk acoustic resonator type label-free biosensor is verified with biotin-streptavidin binding interactions as a model system. …”
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Journal Article -
2
The ties that bind: on affective ties, power, nationalism, and competition over the global distribution of feeling
Published 2025Journal article -
3
Unveiling the chirality of the quantum anomalous Hall effect
Published 2024“…The ordinary and quantum Hall effects with fixed carrier types, electron or hole, exhibit well-defined chirality under external magnetic fields, but the analogous chirality of the quantum anomalous Hall effect (QAHE) remains little explored. …”
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Journal Article -
4
Biocementation of sand filled geotextile tubes
Published 2019“…Nonetheless, the strength and durability of geotextile tubes that filled with sand or clay slurry still need to be improved. …”
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Final Year Project (FYP) -
5
Skyrmion-driven topological Hall effect in a Shastry-Sutherland magnet
Published 2023“…By constructing an effective tight-binding model of conduction electrons coupled to the skyrmion lattice, we clearly demonstrate the appearance of the topological Hall effect. …”
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Journal Article -
6
Binding modes of teixobactin to lipid ii : molecular dynamics study
Published 2018“…Teixobactin (TXB) is a newly discovered antibiotic targeting the bacterial cell wall precursor Lipid II (LII). In the present work, four binding modes of TXB on LII were identified by a contact-map based clustering method. …”
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Journal Article -
7
Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics
Published 2014“…The transcription factor p53 regulates cellular integrity in response to stress. p53 is mutated in more than half of cancerous cells, with a majority of the mutations localized to the DNA binding domain (DBD). …”
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Journal Article -
8
The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator
Published 2025“…In silico analysis using RosettaLigand and GLIDE demonstrated a well-converged pose of SKA-346 in a binding pocket at the interface between the calmodulin N-lobe and the S45A helix in the S4-S5 linker of the KCa3.1 channel. …”
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Journal Article -
9
Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore
Published 2020“…Background: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. …”
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Journal Article -
10
Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents
Published 2021“…Strategies to tackle antibiotic resistance as well as biofilms are urgently needed. Wall teichoic acid (WTA), a generic anionic glycopolymer present on the cell surface of many Gram-positive bacteria, has been proposed as a possible therapeutic target, but its druggability remains to be demonstrated. …”
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Journal Article -
11
Methods for the Study of Galactofuranose in Mycobacteria
Published 2024“…We evaluated strains with varying galactan structures and compared our data to previous characterization of the cell wall to assess the method’s utility. Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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Thesis -
12
Coupled acoustic resonator systems with novel acoustic properties
Published 2021“…The inversion symmetry of the lattice is broken by differing the heights of two resonators within a unit cell, leading to the analogue of valley Hall effect. Similar to a gapped graphene, gapless topological valley edge states are shown at a zigzag domain wall separating different domains with opposite valley Chern numbers, while an armchair domain wall hosts no gapless edge states. …”
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Thesis-Doctor of Philosophy -
13
Synthesis and application of peptidoglycan oligomers as metabolic labeling agents for bacteria
Published 2020“…In the following part, mechanistic studies further supported the hypothesis of enzyme mediated metabolic labeling rather than non-specific binding to bacterial surface. The cell wall-deficient L-form strain of enterococcus showed a drastic reduction in PGO-rhodamine incorporation, and calorimetric studies further confirmed the strong binding between our PGOs and the penicillin-binding protein 1a (PBP1a). …”
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Thesis-Doctor of Philosophy -
14
Seroprevalence of SARS-CoV-2 in children and adolescents
Published 2023“…</p> <br> <p>The findings of ‘STORY’ confirm that SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalisation. …”
Thesis -
15
Effect of post-deposition annealing on the interface electronic structures of Al2O3-Capped GaN and GaN/AlGaN/GaN heterostructure
Published 2019“…The interface electronic structures of GaN and GaN/AlGaN/GaN samples, capped with atomic-layer-deposited Al2O3 and subjected to varying post-deposition annealing (PDA) temperatures, are investigated by X-ray photoelectron spectroscopy (XPS) and Hall-effect measurement. XPS study shows a decrease in the Ga 3d and N 1s core level binding energy after a high-temperature PDA, implying a decrease of the interface defect density and the associated positive trapped-charge. …”
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Journal Article -
16
Enzymatic preparation of diacylglycerols: lipase screening, immobilization, characterization and glycerolysis performance
Published 2024“…Backgrounds: Glycerolysis, with its advantages of readily available raw materials, simple operation, and mild reaction conditions, is a primary method for producing diacylglycerol (DAG). …”
Article -
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Structural features that affect β2 integrin expression and regulation of adhesion
Published 2013“…In contrast, integrins with the β2-G150D mutation have no binding activities. LFA-1 with the β2-G716A mutation is constitutively active to bind ICAM-1 and requires only one activating agents to bind to ICAM-3. …”
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Thesis -
18
Different modes of regulation govern miRNA expression levels in Drosophila melanogaster
Published 2019“…Loquacious (Loqs) is a dsRNA-binding protein that binds Dicer-1 to cleave pre-miRNAs into short duplexes. …”
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Thesis-Doctor of Philosophy -
19
Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2
Published 2015“…Subsequent mTRP-2-cA anchoring to the cell wall of L. lactis showed excitation of FITC conjugate on secondary antibody which signified successful binding of glycosylated TRP-2 on the surface of L. lactis.…”
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Thesis -
20
Anisotropic protein diffusion on nanosurface
Published 2022“…On the MBP surface, HP35 migrates mainly along the zigzag direction but can also easily stride over the ridges and grooves along the armchair direction. Moreover, the mild binding strength between α-PC and HP35 does not cause distortion in the protein structure. …”
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Journal Article