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Biotin-streptavidin binding interactions of dielectric filled silicon bulk acoustic resonators for smart label-free biochemical sensor applications
Published 2014“…Sensor performance of a dielectric filled silicon bulk acoustic resonator type label-free biosensor is verified with biotin-streptavidin binding interactions as a model system. …”
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Journal Article -
2
The ties that bind: on affective ties, power, nationalism, and competition over the global distribution of feeling
Published 2025Journal article -
3
Unveiling the chirality of the quantum anomalous Hall effect
Published 2024“…The ordinary and quantum Hall effects with fixed carrier types, electron or hole, exhibit well-defined chirality under external magnetic fields, but the analogous chirality of the quantum anomalous Hall effect (QAHE) remains little explored. …”
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Journal Article -
4
Biocementation of sand filled geotextile tubes
Published 2019“…Nonetheless, the strength and durability of geotextile tubes that filled with sand or clay slurry still need to be improved. …”
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Final Year Project (FYP) -
5
Skyrmion-driven topological Hall effect in a Shastry-Sutherland magnet
Published 2023“…By constructing an effective tight-binding model of conduction electrons coupled to the skyrmion lattice, we clearly demonstrate the appearance of the topological Hall effect. …”
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Journal Article -
6
Structural characterization of the full-length Hantaan virus polymerase
Published 2024“…We determine a series of structures at resolutions between 2.7 and 3.3 Å of RNA free polymerase comprising the core, core and endonuclease, and a full-length polymerase. The full-length polymerase structure depicts the location of the cap binding and C-terminal domains which are arranged in a conformation that is incompatible with transcription and in a novel conformation not observed in previous conformations of cap-snatching viral polymerases. …”
Journal article -
7
Evaluation of keratin templates on dermal regeneration of full-thickness burns
Published 2024“…Full-thickness burns presents themselves as damages to both epidermis and dermis, and may affect the subcutaneous tissue, muscular, neurovascular, and skeletal structures. …”
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Thesis-Doctor of Philosophy -
8
Structural and functional characterisation of the collagen binding domain of fibronectin
Published 2007“…However, the presence of at least a single GlcNAc sugar residue on the second sugar chain site on 8Fn1 (N- linked to N511) is essential for full affinity binding to collagen. Direct binding of the 8Fn1-9Fn1 module pair to collagen is assessed with a short collagen peptide and the binding is monitored by NMR. …”
Thesis -
9
Binding modes of teixobactin to lipid ii : molecular dynamics study
Published 2018“…Teixobactin (TXB) is a newly discovered antibiotic targeting the bacterial cell wall precursor Lipid II (LII). In the present work, four binding modes of TXB on LII were identified by a contact-map based clustering method. …”
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Journal Article -
10
Structural basis of RNA binding by leucine zipper GCN4
Published 2013“…Further studies in the context of full-length bZIP factors are envisaged to address the biological relevance of LZ RNase activity.…”
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Journal Article -
11
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Published 2025“…Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. …”
Journal article -
12
Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice
Published 2014“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
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Journal Article -
13
The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2
Published 2025Journal article -
14
Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics
Published 2014“…The transcription factor p53 regulates cellular integrity in response to stress. p53 is mutated in more than half of cancerous cells, with a majority of the mutations localized to the DNA binding domain (DBD). …”
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Journal Article -
15
The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator
Published 2025“…In silico analysis using RosettaLigand and GLIDE demonstrated a well-converged pose of SKA-346 in a binding pocket at the interface between the calmodulin N-lobe and the S45A helix in the S4-S5 linker of the KCa3.1 channel. …”
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Journal Article -
16
Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents
Published 2021“…Strategies to tackle antibiotic resistance as well as biofilms are urgently needed. Wall teichoic acid (WTA), a generic anionic glycopolymer present on the cell surface of many Gram-positive bacteria, has been proposed as a possible therapeutic target, but its druggability remains to be demonstrated. …”
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Journal Article -
17
Coupled acoustic resonator systems with novel acoustic properties
Published 2021“…The inversion symmetry of the lattice is broken by differing the heights of two resonators within a unit cell, leading to the analogue of valley Hall effect. Similar to a gapped graphene, gapless topological valley edge states are shown at a zigzag domain wall separating different domains with opposite valley Chern numbers, while an armchair domain wall hosts no gapless edge states. …”
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Thesis-Doctor of Philosophy -
18
Synthesis and application of peptidoglycan oligomers as metabolic labeling agents for bacteria
Published 2020“…In the following part, mechanistic studies further supported the hypothesis of enzyme mediated metabolic labeling rather than non-specific binding to bacterial surface. The cell wall-deficient L-form strain of enterococcus showed a drastic reduction in PGO-rhodamine incorporation, and calorimetric studies further confirmed the strong binding between our PGOs and the penicillin-binding protein 1a (PBP1a). …”
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Thesis-Doctor of Philosophy -
19
Methods for the Study of Galactofuranose in Mycobacteria
Published 2024“…We evaluated strains with varying galactan structures and compared our data to previous characterization of the cell wall to assess the method’s utility. Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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Thesis -
20
Effect of post-deposition annealing on the interface electronic structures of Al2O3-Capped GaN and GaN/AlGaN/GaN heterostructure
Published 2019“…The interface electronic structures of GaN and GaN/AlGaN/GaN samples, capped with atomic-layer-deposited Al2O3 and subjected to varying post-deposition annealing (PDA) temperatures, are investigated by X-ray photoelectron spectroscopy (XPS) and Hall-effect measurement. XPS study shows a decrease in the Ga 3d and N 1s core level binding energy after a high-temperature PDA, implying a decrease of the interface defect density and the associated positive trapped-charge. …”
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Journal Article