The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Pounds, R, Croft, W, Pearce, H, Hossain, T, Singh, K, Balega, J, Jeevan, DN, Sundar, S, Kehoe, S, Yap, J, Moss, P, Zuo, J

“…Discussion: These findings reveal profound modulation of the tumour tissue and systemic profile of NK cells which likely contributes to the high rates of local progression and metastasis seen with OC. …”

Heterogeneity within colorectal cancer cell lines and epigenetic regulation of CD24 by Ibn Ayub, M

“…This thesis investigated the role of methylation in dynamic regulation of CD24 based heterogeneity in colorectal cancer cell lines. First, E-Cadherin variation between the cell lines LS174T and LS180 was investigated to find out whether E-Cadherin had any causal role in the difference in lumen formation between these two cell lines derived from the same tumour. …”

Interaction of TiO2 and ZnO NPs with human skin cells by Gautam, Archana

“…Therefore, the goal of this study is to assess the physiological effects of TiO2 and ZnO NPs interactions with primary human epidermal keratinocytes and dermal fibroblasts, with attention to accurate dosimetry measurements and particle solubility considerations. Since the current findings on NPs interaction with skin cells are mostly based on 2D monolayer cell culture and animal models, in this study, 3D human skin explants have also been used to better understand the effects of NPs in the skin tissue. …”
Get full text
Get full text

Non-targeted metabolomics revealing the effects of bisphenol analogues on human liver cancer cells by Jia, Shenglan, Li, Caixia, Fang, Mingliang, Marques Dos Santos, Mauricius, Snyder, Shane Allen

“…While attenuated glycolysis was observed under BPE treatment. These findings may provide potential biomarkers indicating the cytotoxicity of BPs and prompt a deeper understanding of the intramolecular metabolic processes induced by BPs exposure.…”
Get full text

Anchoring charge selective self-assembled monolayers for tin-lead perovskite solar cells by Zhang, Z, Zhu, R, Tang, Y, Su, Z, Hu, S, Zhang, X, Zhang, J, Zhao, J, Xue, Y, Gao, X, Li, G, Pascual, J, Abate, A, Li, M

“…Overall, this work highlights the underexplored potential of SAMs for perovskite photovoltaics and provides essential findings on the influence of their structural modification.…”

Modeling the Impact of Electrolyte Flow on Heat Management in a Li-Ion Convection Cell by Gao, Weiran, Drake, Javit, Brushett, Fikile R

“…We show, through physics-based electrothermal modeling and dimensional analysis of a single, planar LIB cell, that electrolyte convection can simultaneously draw heat from the cell and suppress heat generation from entropy change, charge-transfer, and ohmic losses, and that the cell temperature rise can be effectively mitigated when heat removal matches or exceeds heat generation. …”
Get full text

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Finally, to determine the developmental changes in Purkinje cells, human Purkinje cells were generated from control and SCA14 iPSCs using a novel simplified protocol. …”

Techniques for analysis and integration of histology data and agent-based modelling of T cell-tumour interactions by Stephens, R

“…<p>Cytotoxic (CD8+) T cells form an important part of the adaptive immune response. …”

Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis by Paley, MA, Yang, X, Hassman, LM, Penkava, F, Garner, LI, Paley, GL, Linskey, N, Agnew, R, Arantes de Faria, PH, Feng, A, Li, SY, Simone, D, Roberson, EDO, Ruzycki, PA, Esaulova, E, Laurent, J, Feigl-Lenzen, L, Springer, LE, Liu, C, Gillespie, GM, Bowness, P, Garcia, KC, Yokoyama, WM

“…In addition, we find an expansion of YeiH-specific CD8 T cells in the blood of axSpA and B27AAU over healthy controls, whereas influenza-specific CD8 T cells were equivalent across groups. …”

15.391 Early Stage Capital, Fall 2003 by Loessberg, Shari

Get full text

Preparation and characterization of photo electrochemical cells based on nanostructured ZnO and multiwalled carbon nanotubes by Ayu, Aaron Alexander

“…The emphasis of this project is to find a cheap and suitable semiconductor and to study its potential and efficiency in water splitting, in order to generate H2 gas for usage as a renewable source of fuel. …”
Get full text

Evaluating the ecotoxicity of agropesticides and environmental water contaminants using cell-line and zebrafish embryonic assays by Tan, Roy Zi Hao

“…The results showed that the pesticides tested exhibited acute lethality and sublethal effects on the model organisms tested, albeit some to a lesser extent than previously reported findings on single active compounds. Our findings also revealed challenges in using a single broad-spectrum solid-phase extraction method to retain pesticide analytes due to their chemical complexity. …”
Get full text

Conformational antibody binding to a native, cell-free expressed GPCR in block copolymer membranes by De Hoog, Hans-Peter M., Lin JieRong, Esther M., Banerjee, Sourabh, Décaillot, Fabien M., Nallani, Madhavan

“…Their biophysical characterization is, however, highly challenging because of their innate instability outside a stabilizing membrane and the difficulty of finding a suitable expression system. We here show the cell-free expression of a GPCR, CXCR4, and its direct embedding in diblock copolymer membranes. …”
Get full text
Get full text

Elucidating the size-dependency of in vitro digested polystyrene microplastics on human intestinal cells health and function by Ma, Yiyuan, Koh, Cheryl Jie Yan, Lim, Hong Kit, Shi, Pujiang, Tay, Chor Yong

“…Interestingly, it is found that the 0.1 µm PS-MPs can perturb redox homeostasis in NCM460 but not in Caco-2 cells. Based on the in vitro experimental boundaries and findings, it is concluded that ingested PS-MPs pose little acute cytotoxic harm to human gastrointestinal health.…”
Get full text

Analysis of hepatocyte antigen presentation and T cell/hepatocyte interaction in the context of hepatitis B virus Infection. by Noviani, Maria.

“…This study aimed to analyze strategies employed by HBV to evade host’s cellular immune response, which requires an interaction of T cell receptor (TCR) and major histocompatibility complex class I (MHC I)/peptide complex for T cell activation. …”
Get full text

Characterization of progesterone receptor isoform-selective activities of progesterone receptor modulators in breast cancer cells. by Leo, Joyce Ching Li.

“…This study reveals the effects of progesterone receptor modulators (PRMs) mediated by PR isoforms in PR-transfected MDA-MB-231 cells. Through PR-A and PR-B, PRMs CP8668, AED and Dex-Mes exhibited progesterone agonist effect in which they induced cell spreading, focal adhesion, cell migration and inhibited cell cycle progression. …”
Get full text

A cross-scale framework for evaluating flexibility values of battery and fuel cell electric vehicles by Liu, Ruixue, He, Guannan, Wang, Xizhe, Mallapragada, Dharik, Zhao, Hongbo, Shao-Horn, Yang, Jiang, Benben

“…This article analyzed and compared the flexibility values of battery electric vehicles and fuel cell electric vehicles for planning and operating interdependent electricity and hydrogen supply chains while considering battery degradation costs. …”
Get full text

Sygyzium claviflorum fruit extract preadipocyte differentiation inhibition in 3T3-L1 cells by Zohdi, Rozaini M., Adli, Muhammad A., Mukhtar, Shahida M., Awang Junaidi, Awang H., Bakar, Md Zuki A.

“…Similarly, this study aimed to establish Sygyzium claviflorum fruit extract (SCFE) anti-adipogenic attributes in 3T3-L1 cells. Methods: The polyphenolic compounds in SCFE were identified with Reverse phase-high performance liquid chromatography (RP-HPLC). …”
Get full text

Critical analysis of the role of biodegradable polymeric scaffolds in differentiation of human embryonic stem cell into cardiomyocytes by Amritamayee Sahoo

“…Owing to the shortage of donors there has been a constant quest to find alternatives to organ transplant. Cell replacement therapy is a promising approach for the treatment of cardiac diseases, but is challenged by a limited supply of appropriate cells. …”
Get full text

B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination by Kotagiri, P, Mescia, F, Rae, WM, Bergamaschi, L, Tuong, ZK, Turner, L, Hunter, K, Gerber, PP, Hosmillo, M, Hess, C, Clatworthy, MR, Goodfellow, IG, Matheson, NJ, McKinney, EF, Wills, MR, Gupta, RK, Bradley, JR, Bashford-Rogers, RJM, Lyons, PA, Smith, KGC

“…B cells are important in immunity to both severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and vaccination, but B cell receptor (BCR) repertoire development in these contexts has not been compared. …”