Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Moreover, the concomitant loss of the charged amino acids in the alternatively spliced version decreases the affinity of p63 to its cognate DNA element two- to threefold. mRNAs encoding full-length p63, as well as its alternatively spliced version, are present in all tissues that we investigated, albeit in differing ratios. …”

The role of calcium dependent neurotransmission in axon path finding, myelination and maintenance of specified cortical projection neuron populations by Korrell, K

Persistent spectral hypergraph based machine learning (PSH-ML) for protein-ligand binding affinity prediction by Liu, Xiang, Feng, Huitao, Wu, Jie, Xia, Kelin

“…We test our PSH-GBT model on three most commonly used datasets, including PDBbind-2007, PDBbind-2013 and PDBbind-2016. Our results, for all these databases, are better than all existing machine learning models with traditional molecular descriptors, as far as we know.…”
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Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

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Analysis of the role played by ligand-induced folding of the cocaine-binding aptamer in the photochrome aptamer switch assay by Shoara, Aron A., Churcher, Zachary R., Steele, Terry W. J., Johnson, Philip E.

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Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

“…The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. …”
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Determining the feasibility of a full-scale randomised controlled trial evaluating rehabilitation for people after acute patellar dislocation by Forde, C

“…This suggests that the low retention may have been for reasons other than the outcome measurement instruments and follow-up methods used.</p> <p>The main finding of this thesis was that a full-scale RCT evaluating rehabilitation is feasible. …”

Barriers and enablers for accessing rehabilitation services: findings from the rehabilitation choices study, part 1—healthcare professionals' perspectives by Hodyl, Nicolette, Mason, Gillian, Ribbons, Karen, Bailey, Lucy, O'Malley, Adrian, Ward, Tracy, Ward, Stephen, Pollack, Michael, Nilsson, Michael, Walker, Frederick Rohan

“…They worked with the study team to codesign the recruitment strategy, participant-facing communications, the interview discussion guide, and the approach to the conduct of activities with participants and in the interpretation and contextualization of findings and all were involved in writing this manuscript.…”
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Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
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Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…The core muscles in the abdominal, back, and hip regions provide stability, enable efficient power transfer between the upper and lower body, and allow for rapid changes in direction - all crucial components for success in badminton. …”
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The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

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Using knowledge translation to support the use of evaluation findings: A case study of the linda mama free maternity program in Kenya by Guleid, FH, Orangi, S, Kairu, A, Arwa, B, Keru, J, Musuva, A, Vilcu, I, Pattnaik, A, Ravishankar, N, Barasa, E

“…Participants reported that this approach made aware them of the gaps in implementation and motivated them to realise the full potential of the Linda Mama program. Using KT, especially when evaluating and refining the implementation of complex health programs with multiple stakeholders, is useful in improving the uptake of evaluation findings. …”

Neural radiance selector: find the best 2D representations of 3D data for CLIP based 3D tasks by Yang, Xiaofeng, Liu, Fayao, Lin, Guosheng

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Impact of molecular linker size on physicochemical properties of assembled gold nanoparticle mono-/multi-layers and their applicability for functional binding of biomolecules by Krikstolaityte, Vida, Hamit-Eminovski, Jildiz, Abariute, Laura, Niaura, Gediminas, Meskys, Rolandas, Arnebrant, Thomas, Lisak, Grzegorz, Ruzgas, Tautgirdas

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Linking dual mode of action of host defense antimicrobial peptide thanatin: structures, lipopolysaccharide and LptAm binding of designed analogs by Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Sperandeo, Paola, Polissi, Alessandra, Bhattacharjya, Surajit

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Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…The reticulon family of integral membrane proteins are conserved across all eukaryotes and typically localize to the endoplasmic reticulum (ER), where they are involved in generating highly-curved tubules. …”
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Simulation on window's energy efficiency using EnergyPlus (Performing simulation on selected windows to find the most energy efficient window for residential housing) by Li, Lan.

“…Seven types of glazing system were selected to find out which type of glazing system is the most energy efficient window. …”
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A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication by Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.

“…We show that DENV2 NS5 arginine 888, located within the carboxy-terminal 18 residues, is completely conserved in all flaviviruses and interacts specifically with the top-loop of 3'SL in the 3'UTR which contains the pentanucleotide 5'-CACAG-3' previously shown to be critical for flavivirus RNA replication. …”
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Are all renewable energy sources the same? a comparative analysis of public perceptions and preferences for renewable energy types in Southeast Asian cities by del Barrio Alvarez, Daniel, Wang, Nan, Sugiyama, Masahiro, Numata, Masako, Thuy, Truong Dang, Abd Aziz, Azlina, Palanca-Tan, Rosalina, Ze Ya, Aung, Yusuf, Ariel Anshory, Abd. Ghani, Awang Noor, Castillo, Gem, Siyaranamual, Martin Daniel

“…This is despite the fact that many of these issues are closely interlinked with and would be exacerbated by climate change. Furthermore, the findings suggest that solar energy is the most preferred renewable source across all urban areas surveyed. …”
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