Cytoophidium complexes resonate with cell fates by Li, Y, Liu, J

“…In 2010, we discovered that the metabolic enzyme CTP synthase (CTPS) can assemble a snake like structure inside cells, which we call the cytoophidium. Including CTPS, an increasing number of metabolic enzymes have been found to form cytoophidia in cells. …”

Regulation and function of innate-like T cells by Hagel, JP

“…It is expressed by NK- and T-cell subsets, particularly by innate-like T cells such as MAIT and γδT cells. …”

An epigenetic analysis of planarian stem cells by Dattani, A

“…Bivalent histone modifications in mammalian embryonic and germline stem cells enable transcriptional poising of genes, and consistent with this we find that bivalent genes in planarian NBs are marked by paused RNA Pol II at the promoter-proximal region. …”

Enhanced restoration of visual code after targeting ON bipolar cells compared to retinal ganglion cells with optogenetic therapy by Rogers, J, Hughes, S, Ebrahimi, A, Allen, A, Storchi, R, Lindner, M, Peirson, S, Badea, T, Hankins, M, Lucas, R

“…Optogenetic therapy is a promising vision restoration method where light-sensitive opsins are introduced to the surviving inner retina following photoreceptor degeneration. The cell type targeted for opsin expression will likely influence the quality of restored vision. …”

RNA interference silencing of interleukin-6 in mesenchymal stromal cells and antitumour efficacy against multiple myeloma cells by Teoh, Hoon Koon

“…In conclusion, both RNAi pathways were equally effective in suppressing IL-6 expression in MSC and displayed in vitro and in vivo antitumor efficacy against U266 cells. These findings support the feasibility of using RNAi as an alternative approach for targeted suppression of IL-6 in MSC to inhibit multiple myeloma cell growth.…”
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Simulation on window's energy efficiency using EnergyPlus (Performing simulation on selected windows to find the most energy efficient window for residential housing) by Li, Lan.

“…Seven types of glazing system were selected to find out which type of glazing system is the most energy efficient window. …”
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Inferring structural variant cancer cell fraction by Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM, Papenfuss, T, Hovens, CM, Markowetz, F, Macintyre, G, PCAWG Consortium

“…We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whole-genome sequencing data. …”

Determination of the life span of inflammatory dendritic cells by Tay, Yong Long

“…Dendritic cells (DCs) are highly efficient antigens presenting cells (APCs) which are responsible in processing and presenting antigens to naïve T-cells thereby activating the adaptive immune response. …”
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Cell-based assays in flowing and sessile drops by Prastowo, A

“…<p>Cell-based assays have been performed in aqueous drops within a bulk immiscible fluid phase, as an alternative to multi-titer plates. …”

Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system by Yu, J. Q., Liu, X. F., Chin, Lip Ket, Liu, Ai Qun, Luo, Kathy Qian

“…This finding may provide new insight into how glucose causes endothelial cell dysfunction, which is the major cause of diabetes-derived complications.…”
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Role of distinct dendritic cell subsets in disseminated candidiasis. by Teoh, Flora Poh Leng.

“…By finding immune cells that play a role in host defense against C. albicans, we may discover potential targets for vaccination and other immunotherapies. …”
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Establishment and optimization of induced pluripotent stem cell technologies by Amir Morshedi

“…This finding has had tremendous impact on drug discovery and disease modeling and there is great hope for these cells to replenish body cells for therapy. …”
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Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

“…By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT activity, we identify a receptor tyrosine kinase inhibitor ponatinib that deregulates ALT mechanisms, induces telomeric dysfunction, reduced ALT-associated telomere synthesis, and targets, in vivo, ALT-positive cells. …”
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Experimental and simulation analysis of energy absorption capacity of 3D printed structure design by Low, Evans Tze Sheng

“…Future studies could explore the other different features or combinations that can be implemented together with a closed-cell foam model, farther optimizing and enhancing the energy absorption of the structure. …”
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Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation by Wu, Zhuoran, Setyawati, Magdiel Inggrid, Lim, Hong Kit, Ng, Kee Woei, Tay, Chor Yong

“…Transcriptome profiling, bioinformatics analysis and siRNA gene knockdown experiments revealed the nuclear factor erythroid 2-related factor 2 (Nrf2) as the key modulator of the ZnO NP-induced drug resistance. Our findings suggest that a ROS-inducing ENM can emerge as a nano-stressor, capable of regulating the chemosensitivity of colon cancer cells.…”
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Cell charactetization in differnet regions of the native annulus fibrous in a porcine intervetebral disc model through cell sorting and molecular analysis by Teo, Tong

“…In this study, we will use cell sorting methods and carry out molecular analysis to find out more about the characteristics of the different regions of the native annulus fibrosus in the porcine intervertebral disc model.…”
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BRCA1 regulation of breast cancer cell motility by Hernandez Nuñez, ZE

“…This thesis hypothesises the potential association between BRCA1 ubiquitin ligase activity and cell migration. Different databases were compiled to 1) identify substrates of BRCA1’s enzymatic activity, 2) find proteins that interact with BRCA1 and 3) find proteins with a role in regulating migration. …”

PCA based feature extraction for cell image retrieval by Ananthagunan Muthukumaran

“…The Eigenimage approach is a principal component analysis method, in which a small set of characteristic pictures are used to describe the variation between cell images. The goal is to find out the eigenvectors (eigenimage) of the covariance matrix of the distribution, spanned by a training sot of cell mages. …”
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Characterizing the Impact of Oligomerization on Redox Flow Cell Performance by Weiss, Trent A, Fan, Gang, Neyhouse, Bertrand J, Moore, Evan B, Furst, Ariel, Brushett, Fikile R

“…Post‐mortem analyses reveal that oligomerization does not meaningfully alter decay processes as evinced by similar capacity fade across all species. Broadly, these findings corroborate and extend upon previously developed relationships between molecular size, electrochemical properties, and flow cell performance.…”
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Vascular tissue engineering: investigation of endothelial cell function by Heng, Jolyn Xiuhui

“…In this study, defined polycaprolactone (PCL) nanofibers of different fiber diameters were treated with NaOH and adsorbed with gelatin to investigate cell attachment efficiency and growth rate. The findings revealed that gelatin adsorbed surfaces does not favour EC proliferation well and led to performing the next modification which is 1 M NaOH treatment for 4 h, 16 h, and 24 h for the PCL surfaces. 1 M NaOH treatment was first performed to improve the hydrophilicity of PCL. …”
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